DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG34120 and LOC101883122

DIOPT Version :9

Sequence 1:	NP_001285513.1	Gene:	CG34120 / 318066	FlyBaseID:	FBgn0083956	Length:	1998	Species:	Drosophila melanogaster
Sequence 2:	XP_021333309.1	Gene:	LOC101883122 / 101883122	-ID:	-	Length:	2391	Species:	Danio rerio

Alignment Length:	2168	Identity:	455/2168 - (20%)
Similarity:	764/2168 - (35%)	Gaps:	691/2168 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    66 TKNQVVPAAFSYICSIENRCQPAHPYEEYSHWKEAPLHSVIDVVNAFVTDERLHK--AVVELAEK 128
            |.||::.|...::.:::|                      :.::||......|::  |.|.:|:.
Zfish   156 TANQLLQARRVFVQNLDN----------------------LKLMNALPLALGLNRIEAAVLMAQT 198

  Fly   129 ANFVSAITTLITSDRFDIIRSNISEIISLVPEIERRMNYSFDIKHLFSNRETFVKLGVLLCGHPF 193
            :..:|.:.|.:...|       .|.::.....::.|             .:.|..:..||||...
Zfish   199 SAHISTLMTALPDFR-------SSALLGAAGSLDFR-------------SDPFGGITQLLCGSRL 243

  Fly   194 PNTDTIPLVNEILESEDFSQANDAEIDAMPTRRRRRYEDLPTDWRPTKYCKRLYRDVTSTNQGKL 258
            ..|..|.           |::.....|...||.........|....:::||.|...:.|::..:|
Zfish   244 NKTSNIT-----------SRSTTTGSDQQNTRAATADNSNSTSTNTSEFCKNLTDSLESSSSTRL 297

  Fly   259 TWNTIKPIIQGRILYTPANAMTESVVKFSNASFEELDRLKQL----------------SRAAATI 307
            .|.|.||.:||:|||||...:|..::|.:|.:|:.|.:...|                |.|....
Zfish   298 IWRTFKPFLQGKILYTPDTNVTRRIIKEANRTFDALAKAGDLADWWLQNKDSLWSFFSSGAQINT 362

  Fly   308 LTKLHTNATFQEAFDNLLKLA--KSPLVKSLVGDDFDIGEIER-----VFEYIRTNQLIYDILTT 365
            |..|..|.......|..|:..  .|.::.:.:   |:..|.||     .|::.............
Zfish   363 LRVLLKNPVLAVVLDQTLENTGFSSAVISNFL---FNGPESERPAGMPSFDWRNVFNATSQSAQQ 424

  Fly   366 VADLMDCVSADRFEAVESVEELHKRAYELNQNKLFLAALNLEDVG-------LKQASYRLHMDTD 423
            :..::.|...|:|.:|.:...|..:|..|.....|.|.|...|:|       .....|::.||..
Zfish   425 LTQILKCFDLDKFSSVSTEALLVNQALALLDLDRFWAGLVFTDLGDPSDPQPPTHIRYKIRMDVQ 489

  Fly   424 NTQPTFENRNRFWFPGPADSMVIDLKYHR-GFVQLKQMVDLGIIKSKREEAGFAPEEDGPESGRS 487
            :|:.|.:.:.|.|.|...|:.:.||:|.| |||.|:.|||..|||
Zfish   490 DTERTDKLKERSWSPTARDNPLNDLRYVRGGFVYLQDMVDRAIIK-------------------- 534

  Fly   488 LSGLFSIKQVENDTPDEDDDDFDLSLEESGDEKAAPKVSASASDHEATTISPSSLDGVTTEEVRV 552
                                                                          ::.
Zfish   535 --------------------------------------------------------------LQT 537

  Fly   553 TTEQTVVSGDPDLLLLKNEDVLKRSKRQGLFDLLGGFGGSGDANKKNKFEVDNMQFYTKQFPYPA 617
            ..:||                            ||                    .|.:|.|||.
Zfish   538 GVQQT----------------------------LG--------------------VYAQQMPYPC 554

  Fly   618 FLNDVFKRGLYLAQGVQVAYLLGLVVFVALS--VRERIWMRESRNSMLMRSMGLKAHSELVAWAL 680
            :::|.|...:    |..:...|.|....::|  ::..:..:|.|...::|..|:...:..:.|..
Zfish   555 YMDDAFVSAI----GTMLPMFLVLAFNYSVSEIIKGLVLEKERRLKEVLRVSGVSNSTIRLCWFA 615

  Fly   681 MSFLELCVIFALISGVLYSGGILGYTNWFFMMFYCLSFGLCLISFCYMCTNFFNSANIGAVASAL 745
            .:.:.|.|..||||.::..|.:|.|::...:..:.|.|.|..:..|:..:.||:.||:.|....|
Zfish   616 ENMILLMVPCALISVMVKYGKVLRYSDPSVIFVFLLVFCLATVMQCFFISVFFSRANLAAACGGL 680

  Fly   746 LFFISLCPFII------VLMFDAKLSVFESFLVDLSFTTAFAKGWGELIRMELQQEGLTVRHLIQ 804
            |:|:...|.::      ||.|.||::      ..|....||..|.......|.|..|:...: |:
Zfish   681 LYFLLYLPHVLCYAWRDVLGFGAKIA------TSLLSCVAFGYGCENFSTYEAQGVGIQWSN-IR 738

  Fly   805 VGPA---RSECAMALLMFLLDLLLYAVI------------GLAYQRY------------------ 836
            ..|.   |....:::.|.|.|.|:|..:            |:|...|
Zfish   739 SSPQDNDRYSFIVSIFMMLFDALIYWTLTWYIENVYPGQYGIAKPWYFPFTSSYWCGSRVGSDGH 803

  Fly   837 ----KKTDNYS-FVKVSRSQLDGKLGASLVNVSKLY--GSKCAVSNLSLDFARNQVSCLLGRNGA 894
                :..:|.| |::...|.|  |.|..:.|:.|:|  |:|.||..|||||.::.::..||.|||
Zfish   804 PDLLQDLENQSGFLEKPPSGL--KPGVCIRNLVKVYKTGNKLAVDGLSLDFYQDHITSFLGHNGA 866

  Fly   895 GKSTLIKLLTGQIRQSSGKVLLAG----------EHQVGVCWQDNILIPTLTAREHLQLYAQIKI 949
            ||:|.:.:|||....:||...:.|          ..|:|:|.|.|:|...||..||:..||::|
Zfish   867 GKTTTMSILTGLFAPTSGTAYINGYDIRTDMDCIRKQLGMCPQHNVLFDDLTVEEHIYFYARLK- 930

  Fly   950 PPGGSGGVEEIRSEVAQTLQSLNFGKHESYPSWQLSGGYRRRLCVAIAFIASPSVVILDEPCNGV 1014
              |.|.  :|::.|:.|.::.:.........:..||||.:|:|.|||||:...:|||||||..||
Zfish   931 --GRSS--KEVKKEIDQMIKDVGLPHKRKDLAKNLSGGMQRKLSVAIAFVGGSNVVILDEPTAGV 991

  Fly  1015 DAKARKDIWQLIERLRQGRAVIFATHFMDEAKYLSDSLVIMRNGRIIAQHSRDSLQRLCTSNYSI 1079
            |..||:.||:|:.:.:|||.:|.:||.||||..|.|.:.|:.:||:          :.|.|  |:
Zfish   992 DPYARRGIWELLLKYKQGRTIILSTHHMDEADILGDRVAIISHGRV----------QCCGS--SL 1044

  Fly  1080 RLRCADATGVTFVIQKAQQLLPQTQVTHS------------------GAADYPHSLTINASYAEH 1126
            .|:.....|....|.:|.|.....|...|                  .:.|.|....::.....|
Zfish  1045 FLKKTYGRGYYLTIARANQERAPAQCVPSPEEFDQSSLDEGICSDSISSLDPPDVSDVSRLVRRH 1109

  Fly  1127 LTPGAVEFLE---------LLQSQVTAGSIS------DVELTT---------SSSLEQEFEQLNR 1167
            : |.| ||||         |..|..|.||.:      |:|..|         .:|||:.|.::
Zfish  1110 V-PEA-EFLEAVGQELVYVLPYSGATNGSFATLFKELDLEKNTLGVTSYGISDTSLEEIFLKV-- 1170

  Fly  1168 NGEDAG---------PRRPASDRSGVVAGPAMI--------------------------TDEPPT 1197
             .||.|         .::|.|  |..::|...|                          |..|..
Zfish  1171 -AEDTGVDVESHDKPKQKPRS--SSRISGKQSISSALECRDAKTVKNEAKVRFASRVEDTHRPMC 1232

  Fly  1198 A--------------CKQFRLLMGKRLRHLSRNYRLLLYVLLLPALFELCAMWFVSYRLEDDFDT 1248
            |              .:||..|..||..|..|:.:.::..:::||.|...|:         .|..
Zfish  1233 ANGKGSDVINGWSLIRQQFLALFIKRFHHARRSRKGIIAQVVMPAFFVCLAL---------IFSL 1288

  Fly  1249 VLP---------LSRSLY--PQTAQF-------LSHERATS-------FSEKLY---PQLRTSCD 1285
            ::|         |...:|  ||...:       :..|:.|:       |..:..   |..|..|.
Zfish  1289 IVPPFNEYPSLELQPWMYGAPQNTFYSFDGPGVVQVEKVTNALLNSPGFGTRCMSTNPIPRLPCV 1353

  Fly  1286 HLGECRVF----------------------------NTSQQSY---------------------- 1300
            ..|....|                            :|:::|:
Zfish  1354 STGSTNWFTPAVDPSISDIFDKGNWTMQNPSPACQCSTAERSFMLPDCPPGAGGLPPPQRTQNTT 1418

  Fly  1301 ------------DWVLNSWGEYSERRYGGYG---------LNGSGAT------------------ 1326
                        |::|.::.:..:.||||:.         ||.|..|
Zfish  1419 DTLQNVTGRNMTDFLLKTYQKSGKIRYGGFSVGGVNSQVRLNESDITTLVSDLRSVFNVSQFKQS 1483

  Fly  1327 ---------------------VWYNNKGYHSMMAWLNDLNSELLRTTM----NDSESSILTLNEP 1366
                                 ||:.|.|:||::::||..::..||..:    ...:..|.|.|.|
Zfish  1484 EDIFQAIRLFLLELGTRDNMKVWFYNPGWHSLVSFLNVASNGALRGNLPAGRRPEDYGITTFNHP 1548

  Fly  1367 WKLGFAELSTSSILRQAGDGSMVFILLIAFGLVVASGSVYLVNERVNGEKLQQRLCGVSAVTYWL 1431
            ..|...:|||:::...:.|..:...::.|...:.||..::|:.|||...|..|.:.||:...|||
Zfish  1549 LNLTREQLSTAALASSSTDVVVAICVIFAMSFIPASFVLFLIQERVTKAKHLQFVSGVNPTIYWL 1613

  Fly  1432 VALVWDYLVMVLGLIVCLVVILMFGMPVFVDRQQLVGIIGLSLAFSFACVPSVHVAEKIFSDSSI 1496
            ....||....::..::.:::.|.|....:|....|..:|.|...:.::..|.::....:||..|.
Zfish  1614 ANFAWDMCNYIVPCVIVIIIFLCFQQKSYVSPPNLPALILLLALYGWSITPMMYPFSFVFSVPST 1678

  Fly  1497 AIVSIFCANLIVPLVTMGIILILGVVGDGPAWDDWRHALNQAFLIFPIHALGDGFLELCKNYMVA 1561
            |.|.:.|.||.:. :...:...:..:.|.|........:.||.|:||...||.|.:::.||..||
Zfish  1679 AYVVLTCINLFIG-INGSVATFVMELFDDPNITRINDIVKQALLVFPHFCLGRGLMDMAKNQAVA 1742

  Fly  1562 LVFRRYDIDSYKHPLASDLLGRHFTALLLVGVAALIINVLIEWHLLRRLWQRVERLLDCTYRREL 1626
            .:::....|.:.:||..:::|::..|:.:.|.....:.:||::...            |..|
Zfish  1743 TLYQNLGEDRFVNPLTWNMVGKNLFAMSIQGAVMFAVTLLIQYKFF------------CKPR--- 1792

  Fly  1627 DKLGQLKLVNIQSIFKSCVDTGEAVRAENLWLAYRRGHYAVRNVNFSVQRGECFGLLGKNGAGKS 1691
                     :::|.|.|..:..|.|..|      |...|                    ||..:.
Zfish  1793 ---------SVKSPFTSSAEEDEDVARE------RERVY--------------------NGGAQK 1822

  Fly  1692 TIFKLLTGQLQPDVGQIYFEQPGISYCPQSNPLDPLLTTTECIRFYGRLRGIRDLDQFLDRVLDT 1756
            .:..:.      |:.::..:.|.::..     ||..|..|                .|...|:..
Zfish  1823 DLLHIC------DLTKVLLKNPVLAVV-----LDQTLENT----------------GFSSAVISN 1860

  Fly  1757 Y------ELRP-----YKDVQVRNLSGGNRRKLTVAVTCCGCTPTVLMDEPTSDMDPVTRDMVYA 1810
            :      ..||     :....|.|.:..:.::||..:..|    ..|:...|....|..||
Zfish  1861 FLFNGPESERPAGMPSFDWRNVFNATSQSAQQLTQILKVC----LHLLKGVTKSWSPTARD---- 1917

  Fly  1811 TIEQLLLARRAVVLTSHSVSEIEHLCQRVAVLRAGQVIASDSPQR--LKSEHG-----GYYA--- 1865
                            :.::::.:       :|.|.|...|...|  :|.:.|     |.||
Zfish  1918 ----------------NPLNDLRY-------VRGGFVYLQDMVDRAIIKLQTGVQQTLGVYAQQM 1959

  Fly  1866 -VTCFCGPAQQAILSRSLNQRLP 1887
             ..|:...|    ..|||.:.||
Zfish  1960 PYPCYMDDA----FLRSLTRSLP 1978

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34120	NP_001285513.1	ABC2_membrane_3	<621..760	CDD:289468	35/146 (24%)
		ABC_subfamily_A	859..1073	CDD:213230	85/225 (38%)
		drrA	865..1162	CDD:130256	114/350 (33%)
		ABC2_membrane_3	1230..1601	CDD:289468	98/512 (19%)
		Mem_trans	1436..>1552	CDD:304621	27/115 (23%)
		ABC_subfamily_A	1651..1857	CDD:213230	31/218 (14%)
		drrA	1666..1945	CDD:130256	39/244 (16%)
LOC101883122	XP_021333309.1	AAA	1..1833	CDD:333001	419/1965 (21%)
LOC101883122	XP_021333309.1	AAA	1835..>2372	CDD:333001	36/200 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010