DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG34120 and abca12

DIOPT Version :9

Sequence 1:	NP_001285513.1	Gene:	CG34120 / 318066	FlyBaseID:	FBgn0083956	Length:	1998	Species:	Drosophila melanogaster
Sequence 2:	XP_031748843.1	Gene:	abca12 / 101731410	XenbaseID:	XB-GENE-6041943	Length:	7516	Species:	Xenopus tropicalis

Alignment Length:	2193	Identity:	516/2193 - (23%)
Similarity:	875/2193 - (39%)	Gaps:	542/2193 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   108 VVNAFVTDE--RLHKAVV--------ELAEKANFVSAITTLITSDRFDII---------RSNISE 153
            :::.|||.:  ||:..:|        .|:.:..:..||..|...|.|.:.         ::.:..
Frog  5529 IIDGFVTLDNCRLNTFIVTEPFRVFCTLSSEQGYQMAIIFLQNVDLFKLFYRLMVPTTWQTALDL 5593

  Fly   154 IISLVPEIERRMNYSF-------DIKHLFSNRETFVKL-----GVLL-----CGHPFP------- 194
            |::::.::...:|...       ::|.:|....||:.|     ..||     ...|.|
Frog  5594 ILTVLDKLMNDLNTMLANFPSEQELKQMFDAINTFMNLTAKSKSTLLRRKRSAAAPTPTILDATK 5658

  Fly   195 -----NTDTIPLVNEILESEDFSQANDAEIDAMPTRRRRRYEDLPTD----WRPTKYCKRLYRDV 250
                 |..::.|:.:::.|...|.|..|.               |||    .....:|..|:.::
Frog  5659 AICAGNYSSLRLILQMINSTRNSNARSAS---------------PTDSFGISTNNTFCDNLFNNL 5708

  Fly   251 TSTNQGKLTWNTIKPIIQGRILYTPANAMTESVVKFSNASFEEL--------------------- 294
            .||..|...|..:||::.|:|||||.|.:|:.:::.:||:.:::
Frog  5709 VSTTSGTAYWLLLKPLLYGQILYTPYNNLTKQIMEKANATIQQVVAYKGNVSTWVTSIQQLLNQW 5773

  Fly   295 DRLKQLSRAAATILTKLH---TNATFQEAFDNLLKLAKSPLVKSLVGDDFDIGEIERVFEYIRTN 356
            |:|:|    |.|::.:|.   .|:.......|.|....|.:..:       |.....:...:.||
Frog  5774 DKLQQ----AGTLIGRLQELLNNSVIDNILTNFLNTNASHINNT-------INSALNIINLLNTN 5827

  Fly   357 ----QLIYDILTTVADLMDCVSADRFEAVESVEELHKRAYEL-NQNKLFLAA---LNLEDVGLKQ 413
                |....|.|.:.:|:.|::.:|.:.:.||||:..:|.|| |.||||.|.   |..|..|..:
Frog  5828 INNIQQFQPIATVINNLLSCMTYNRIQPMNSVEEMQAKAVELQNNNKLFAAVAFDLPSETTGQSK 5892

  Fly   414 ASYRLHMD---TDNTQPTFEN-----RNRFWFPGPADSMVIDLKYHRGFVQLKQMVDLGIIKSKR 470
            ||:.|...   |.:.:|....     |..:|.|.||.|:   .||.||||.|::.:|..||:.:
Frog  5893 ASFNLPKQIKYTISMEPVLSEDTNIIRKSYWTPVPASSL---NKYSRGFVYLQENIDRAIIEMQ- 5953

  Fly   471 EEAGFAPEEDGPESGRSLSGLFSIKQVENDTPDEDDDDFDLSLEESGDEKAAPKVSASASDHEAT 535

Frog  5954 ----------------------------------------------------------------- 5953

  Fly   536 TISPSSLDGVTTEEVRVTTEQTVVSGDPDLLLLKNEDVLKRSKRQGLFDLLGGFGGSGDANKKNK 600
                                                                       .||
Frog  5954 -----------------------------------------------------------TNK--- 5956

  Fly   601 FEVDNMQFYTKQFPYPAFLNDVFKRGLYLAQ---GVQVAYLLGLVVFVALSVRERIWMRESRNSM 662
             .|.|:....:..|:|.     :||..:||.   .:.:|.::..|:|::..|::.:..:|.|...
Frog  5957 -SVANVGLQYQSVPFPC-----YKRDRFLASMGYTLPIALMITWVLFISAFVKKIVHEKEMRLHE 6015

  Fly   663 LMRSMGLKAHSELVAWALMSFLELCVIFALISGVLYSGGILGYTNWFFMMFYCLSFGLCLISFCY 727
            .||.||:.:.|...||.:.|...|.:..:::..:|..|.||..:|.|.:....|.:.|.:|:..|
Frog  6016 YMRMMGVNSSSHFCAWFIESASFLLITVSILVLLLKFGQILPSSNGFILFLLFLDYSLTIIAMSY 6080

  Fly   728 MCTNFFNSANIGAVASALLFFISLCPFIIVLMFDAKLSVFESFLVDLSFTTAFAKGWGELIRMEL 792
            :.:.||::.|:..::.:|::.|:..|||::....:.||.....|:.:...||.:.....::..|.
Frog  6081 LISVFFHNTNVAGLSGSLIYIITFFPFIVIATKSSVLSFSAKTLLCIFSPTALSNAIQYVVYYEE 6145

  Fly   793 QQEGLTVRHLIQVGPARSECA----MALLMFLLDLLLYAVI------------------------ 829
            |..|:...:: .:.|...:..    :..|:| :|.::|.::
Frog  6146 QSVGIQWSNM-YISPLLGDSMTFGWLCWLLF-IDAMIYFLVGFYIRMVFPGKYGIPAPWYFPFQM 6208

  Fly   830 -------GLAYQRYKKTDNYSFVKVSRSQL-------------------DGKLGASLVNVSKLYG 868
                   ||...|..|:...:|..:....:                   |..:|.||..::|::.
Frog  6209 SFWLKCCGLESLRPTKSSGLTFTNIMADNIYHKKGAENDLCSLNEQEPNDLTVGVSLHGLTKVFQ 6273

  Fly   869 SKCAVSNLSLDFARNQVSCLLGRNGAGKSTLIKLLTGQIRQSSGKVLLAGE----------HQVG 923
            ||.||:||:|:|....::.|||.|||||:|.:.:|||....|||.:.:.|:          ..:|
Frog  6274 SKTAVNNLNLNFYEGHITALLGHNGAGKTTTLSMLTGLFGASSGTIYVYGDDIRTNLDRARSNMG 6338

  Fly   924 VCWQDNILIPTLTAREHLQLYAQIKIPPGGSGGVEEIRSEVAQTLQSLNFGKHESYPSWQLSGGY 988
            ||.|.::....||.:|||.||..||.|.....   .:..||.:.|:......|...|...||||.
Frog  6339 VCMQYDVHFDHLTTKEHLLLYGSIKAPHWTRA---HLHIEVKRNLKDTGLYNHRHKPVKALSGGM 6400

  Fly   989 RRRLCVAIAFIASPSVVILDEPCNGVDAKARKDIWQLIERLRQGRAVIFATHFMDEAKYLSDSLV 1053
            :|:|.:.||.|....|||||||..|||..:|:.||::|.:.::.:.:|.:||.:|||:.|||.:.
Frog  6401 KRKLSICIALIGGSKVVILDEPTTGVDPCSRRSIWEVISKQKKDKTIILSTHHLDEAEVLSDRIA 6465

  Fly  1054 IMRNGRIIAQHSRDSLQRLCTSNYSIRL-----------RCADATGVTFVIQKAQQLLPQTQVTH 1107
            .:..|.:....:...|::...|.|.:.|           .| |...||.:|:..   :|:..:..
Frog  6466 FLEQGGLKCCGTPLYLKQKFGSGYHLTLTKKFPNRENQEEC-DVELVTDLIKSH---IPEACLKE 6526

  Fly  1108 SGAADYPHSL-TINASYAEHLTPGAVEFLELLQS--------QVTAGSISDVELTTSSSLEQEFE 1163
            ....:..:.| :.||..:     ||  :|.|||:        .:....|||      :::|:.|.
Frog  6527 DVGGELVYLLPSFNAEIS-----GA--YLSLLQALDSRMNDLHIGCYGISD------TTIEEVFL 6578

  Fly  1164 QLNRN-GEDAGPRRPASDRSGVVAGP----------AMIT--------DEPPT----------AC 1199
            :|..| .||.......|....||..|          ..:|        |:|.|          ..
Frog  6579 KLTDNLDEDEQDAMAWSSTKTVVPIPNEENLHVQDELSLTNYRFTDRDDQPLTNEEKLTGVSLLL 6643

  Fly  1200 KQFRLLMGKRLRHLSRNYRLLLYVLLLPALFELCAMWFVSYRLEDDFDTVLPLSRSLYPQTAQFL 1264
            |:...:..||..:..||::.|:..:|||.||.:.||...|..........|.|:..||..::|.:
Frog  6644 KKIMAIFIKRFHNSRRNWKGLISQVLLPVLFVVIAMGLGSLSSSAVSFPELLLTPDLYGTSSQSV 6708

  Fly  1265 SHERATSFSEKL------YPQLRTSC------------------DH----LGECR---------- 1291
            :.......|..|      :|.:..||                  |:    .|.|.
Frog  6709 AFGLYNESSSNLVSAMNSFPGIDNSCLNQNSNCLSQNGLGLWTSDNQSLSYGSCNCSTGAPVCDA 6773

  Fly  1292 ---------------VFNTS---QQSYDWVLNSWGEYSERRYGGYGL-----------------N 1321
                           ::|.|   .:||  :|.:..::.::||||:..                 |
Frog  6774 SSAAPPHRRTFSEQMLYNVSGYNMESY--LLTTNLQFIQKRYGGWSFGIPWVSSKLETLVPQNPN 6836

  Fly  1322 GSGATVWYNNKGYHSMMAWLNDLNSELLRTTMNDSES---SILTLNEPWKLGFAELSTSSILRQA 1383
            .:.:.||:||.|.||:.|::|..::.||||.:..:||   ||...::|......:.||:..|...
Frog  6837 MTISKVWFNNDGPHSLPAFINSFSNFLLRTNLPSNESDQYSISVASKPLSGTVIQTSTTVTLVNT 6901

  Fly  1384 GDGSMVFILLIAFGLVVASGSVYLVNERVNGEKLQQRLCGVSAVTYWLVALVWDYLVMVLGLIVC 1448
               .:...:|..:.:..||.:.|:|.|..:|.|..|.:.||....||:...::|.::.::.:.:.
Frog  6902 ---LIALCVLAGYSITTASFATYVVKEHHSGAKRLQHIAGVGETCYWVTNFIYDSIIYLIPVSLS 6963

  Fly  1449 LVVILMFGMPVFVDRQQLVGIIGLSLAFSFACVPSVHVAEKIFSDSSIAIVSIFCANLIV---PL 1510
            |..|.:|.:|.|.|...|..:..|.:.|.||....:::....|.....|.::....||.:   .:
Frog  6964 LATIAIFKLPAFYDYPNLGAMSLLFILFGFATFSWMYLLAGTFKSPGNAFITYVSINLFIGINTI 7028

  Fly  1511 VTMGIILILGVVGDGPAWDDWRHALNQ-------AFLIFPIHALGDGFLELCKNYMVALVFRRYD 1568
            ::..::..| .|...|:..|:: :|||       .|.|||....|.|.:.|.:...:.:....|.
Frog  7029 ISTSVVYFL-YVQRSPSDSDYQ-SLNQTYTVLTDVFKIFPQFCFGYGMIMLSQQQALQMQSAIYG 7091

  Fly  1569 IDSYKHPLASDLLGRHFTALLLVGVAALIINVLIEWHLLRRLWQRVER-----LLDCTYRRELDK 1628
            ..|..:..:.|:||...:|:.:.|....::.:||...::......|:|     .|..|...|.|:
Frog  7092 GTSTTNIFSMDILGWMLSAMAIQGAFCFLLRLLINDGIIFSFKSFVKRNCMKSYLVVTKNPEEDE 7156

  Fly  1629 LGQLKLVNIQSIFKSCVDTGEA----VRAENLWLAYR---RGHYAVRNVNFSVQRGECFGLLGKN 1686
            ..:.:        :..||:|:|    ::.:.|...|.   :...||.|:..|:..||||||||.|
Frog  7157 DVRAE--------RERVDSGQADPDLLQLQGLTKVYHHVGKNMVAVNNMTLSIPAGECFGLLGVN 7213

  Fly  1687 GAGKSTIFKLLTGQLQPDVGQIYF---------------EQPGISYCPQSNPLDPLLTTTECIRF 1736
            ||||:|.||:|||.:.|..|.|..               :.....||||.:.||.|||..|.:.|
Frog  7214 GAGKTTTFKMLTGDVAPSKGNIQVRNNAGNLENVLGFNTDWSAFGYCPQEDALDELLTGEEHLYF 7278

  Fly  1737 YGRLRGI--RDLDQFLDRVLDTYELRPYKDVQVRNLSGGNRRKLTVAVTCCGCTPTVLMDEPTSD 1799
            |.||.||  :.:......:|...:|..|||......|.|.||||:.|:...|....:|:|||:|.
Frog  7279 YARLHGIPEKKIKAVSFSLLQKLQLVQYKDRTTAAYSCGTRRKLSTALALIGRPSILLLDEPSSG 7343

  Fly  1800 MDPVTRDMVYATIEQLLLARRAVVLTSHSVSEIEHLCQRVAVLRAGQVIASDSPQRLKSEHGGYY 1864
            |||.|:..::..|.:.:..:.||||||||:.|.|.||.|:|::..|:.....|.|.:||..|..:
Frog  7344 MDPKTKRHLWKIISEEVKEKCAVVLTSHSMEECEALCTRLAIMVKGKFQCIGSLQHIKSRFGSGF 7408

  Fly  1865 AVTCFCGPAQQAI--LSRSLNQRLPGA--RDLQHYAHSLRFLVRVRSPGSLGDAPLL----SELF 1921
            .|......:...:  |:..:.:..|..  :| ||:. .:.:.|.|.:.|..|...||    |:|
Frog  7409 TVKMHLKDSSVNVEALTSFMCRHFPNTYLKD-QHFT-MVEYHVPVTAGGVAGIFDLLEANKSDL- 7470

  Fly  1922 AILCDVCVNVARFSLSRCRFETVFERILDSSESNGSNGVHKDQQQQVA 1969
                    ::..||:|:...:.||.....|..|..::.|:..:.||.|
Frog  7471 --------DIIHFSVSQTTLDEVFINFAQSQVSPDNSSVNSQELQQNA 7510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34120	NP_001285513.1	ABC2_membrane_3	<621..760	CDD:289468	37/141 (26%)
		ABC_subfamily_A	859..1073	CDD:213230	80/223 (36%)
		drrA	865..1162	CDD:130256	100/326 (31%)
		ABC2_membrane_3	1230..1601	CDD:289468	98/456 (21%)
		Mem_trans	1436..>1552	CDD:304621	29/125 (23%)
		ABC_subfamily_A	1651..1857	CDD:213230	84/225 (37%)
		drrA	1666..1945	CDD:130256	102/303 (34%)
abca12	XP_031748843.1	rim_protein	4..>82	CDD:130324
abca12	XP_031748843.1	rim_protein	5675..7493	CDD:130324	485/2028 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010