DRSC/TRiP Functional Genomics Resources

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Protein Alignment ldd and abca12

DIOPT Version :10

Sequence 1:NP_001285513.1 Gene:ldd / 318066 FlyBaseID:FBgn0083956 Length:1998 Species:Drosophila melanogaster
Sequence 2:XP_031748843.1 Gene:abca12 / 101731410 XenbaseID:XB-GENE-6041943 Length:7516 Species:Xenopus tropicalis


Alignment Length:2193 Identity:516/2193 - (23%)
Similarity:875/2193 - (39%) Gaps:542/2193 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly   108 VVNAFVTDE--RLHKAVV--------ELAEKANFVSAITTLITSDRFDII---------RSNISE 153
            :::.|||.:  ||:..:|        .|:.:..:..||..|...|.|.:.         ::.:..
 Frog  5529 IIDGFVTLDNCRLNTFIVTEPFRVFCTLSSEQGYQMAIIFLQNVDLFKLFYRLMVPTTWQTALDL 5593

  Fly   154 IISLVPEIERRMNYSF-------DIKHLFSNRETFVKL-----GVLL-----CGHPFP------- 194
            |::::.::...:|...       ::|.:|....||:.|     ..||     ...|.|       
 Frog  5594 ILTVLDKLMNDLNTMLANFPSEQELKQMFDAINTFMNLTAKSKSTLLRRKRSAAAPTPTILDATK 5658

  Fly   195 -----NTDTIPLVNEILESEDFSQANDAEIDAMPTRRRRRYEDLPTD----WRPTKYCKRLYRDV 250
                 |..::.|:.:::.|...|.|..|.               |||    .....:|..|:.::
 Frog  5659 AICAGNYSSLRLILQMINSTRNSNARSAS---------------PTDSFGISTNNTFCDNLFNNL 5708

  Fly   251 TSTNQGKLTWNTIKPIIQGRILYTPANAMTESVVKFSNASFEEL--------------------- 294
            .||..|...|..:||::.|:|||||.|.:|:.:::.:||:.:::                     
 Frog  5709 VSTTSGTAYWLLLKPLLYGQILYTPYNNLTKQIMEKANATIQQVVAYKGNVSTWVTSIQQLLNQW 5773

  Fly   295 DRLKQLSRAAATILTKLH---TNATFQEAFDNLLKLAKSPLVKSLVGDDFDIGEIERVFEYIRTN 356
            |:|:|    |.|::.:|.   .|:.......|.|....|.:..:       |.....:...:.||
 Frog  5774 DKLQQ----AGTLIGRLQELLNNSVIDNILTNFLNTNASHINNT-------INSALNIINLLNTN 5827

  Fly   357 ----QLIYDILTTVADLMDCVSADRFEAVESVEELHKRAYEL-NQNKLFLAA---LNLEDVGLKQ 413
                |....|.|.:.:|:.|::.:|.:.:.||||:..:|.|| |.||||.|.   |..|..|..:
 Frog  5828 INNIQQFQPIATVINNLLSCMTYNRIQPMNSVEEMQAKAVELQNNNKLFAAVAFDLPSETTGQSK 5892

  Fly   414 ASYRLHMD---TDNTQPTFEN-----RNRFWFPGPADSMVIDLKYHRGFVQLKQMVDLGIIKSKR 470
            ||:.|...   |.:.:|....     |..:|.|.||.|:   .||.||||.|::.:|..||:.: 
 Frog  5893 ASFNLPKQIKYTISMEPVLSEDTNIIRKSYWTPVPASSL---NKYSRGFVYLQENIDRAIIEMQ- 5953

  Fly   471 EEAGFAPEEDGPESGRSLSGLFSIKQVENDTPDEDDDDFDLSLEESGDEKAAPKVSASASDHEAT 535
                                                                             
 Frog  5954 ----------------------------------------------------------------- 5953

  Fly   536 TISPSSLDGVTTEEVRVTTEQTVVSGDPDLLLLKNEDVLKRSKRQGLFDLLGGFGGSGDANKKNK 600
                                                                       .||   
 Frog  5954 -----------------------------------------------------------TNK--- 5956

  Fly   601 FEVDNMQFYTKQFPYPAFLNDVFKRGLYLAQ---GVQVAYLLGLVVFVALSVRERIWMRESRNSM 662
             .|.|:....:..|:|.     :||..:||.   .:.:|.::..|:|::..|::.:..:|.|...
 Frog  5957 -SVANVGLQYQSVPFPC-----YKRDRFLASMGYTLPIALMITWVLFISAFVKKIVHEKEMRLHE 6015

  Fly   663 LMRSMGLKAHSELVAWALMSFLELCVIFALISGVLYSGGILGYTNWFFMMFYCLSFGLCLISFCY 727
            .||.||:.:.|...||.:.|...|.:..:::..:|..|.||..:|.|.:....|.:.|.:|:..|
 Frog  6016 YMRMMGVNSSSHFCAWFIESASFLLITVSILVLLLKFGQILPSSNGFILFLLFLDYSLTIIAMSY 6080

  Fly   728 MCTNFFNSANIGAVASALLFFISLCPFIIVLMFDAKLSVFESFLVDLSFTTAFAKGWGELIRMEL 792
            :.:.||::.|:..::.:|::.|:..|||::....:.||.....|:.:...||.:.....::..|.
 Frog  6081 LISVFFHNTNVAGLSGSLIYIITFFPFIVIATKSSVLSFSAKTLLCIFSPTALSNAIQYVVYYEE 6145

  Fly   793 QQEGLTVRHLIQVGPARSECA----MALLMFLLDLLLYAVI------------------------ 829
            |..|:...:: .:.|...:..    :..|:| :|.::|.::                        
 Frog  6146 QSVGIQWSNM-YISPLLGDSMTFGWLCWLLF-IDAMIYFLVGFYIRMVFPGKYGIPAPWYFPFQM 6208

  Fly   830 -------GLAYQRYKKTDNYSFVKVSRSQL-------------------DGKLGASLVNVSKLYG 868
                   ||...|..|:...:|..:....:                   |..:|.||..::|::.
 Frog  6209 SFWLKCCGLESLRPTKSSGLTFTNIMADNIYHKKGAENDLCSLNEQEPNDLTVGVSLHGLTKVFQ 6273

  Fly   869 SKCAVSNLSLDFARNQVSCLLGRNGAGKSTLIKLLTGQIRQSSGKVLLAGE----------HQVG 923
            ||.||:||:|:|....::.|||.|||||:|.:.:|||....|||.:.:.|:          ..:|
 Frog  6274 SKTAVNNLNLNFYEGHITALLGHNGAGKTTTLSMLTGLFGASSGTIYVYGDDIRTNLDRARSNMG 6338

  Fly   924 VCWQDNILIPTLTAREHLQLYAQIKIPPGGSGGVEEIRSEVAQTLQSLNFGKHESYPSWQLSGGY 988
            ||.|.::....||.:|||.||..||.|.....   .:..||.:.|:......|...|...||||.
 Frog  6339 VCMQYDVHFDHLTTKEHLLLYGSIKAPHWTRA---HLHIEVKRNLKDTGLYNHRHKPVKALSGGM 6400

  Fly   989 RRRLCVAIAFIASPSVVILDEPCNGVDAKARKDIWQLIERLRQGRAVIFATHFMDEAKYLSDSLV 1053
            :|:|.:.||.|....|||||||..|||..:|:.||::|.:.::.:.:|.:||.:|||:.|||.:.
 Frog  6401 KRKLSICIALIGGSKVVILDEPTTGVDPCSRRSIWEVISKQKKDKTIILSTHHLDEAEVLSDRIA 6465

  Fly  1054 IMRNGRIIAQHSRDSLQRLCTSNYSIRL-----------RCADATGVTFVIQKAQQLLPQTQVTH 1107
            .:..|.:....:...|::...|.|.:.|           .| |...||.:|:..   :|:..:..
 Frog  6466 FLEQGGLKCCGTPLYLKQKFGSGYHLTLTKKFPNRENQEEC-DVELVTDLIKSH---IPEACLKE 6526

  Fly  1108 SGAADYPHSL-TINASYAEHLTPGAVEFLELLQS--------QVTAGSISDVELTTSSSLEQEFE 1163
            ....:..:.| :.||..:     ||  :|.|||:        .:....|||      :::|:.|.
 Frog  6527 DVGGELVYLLPSFNAEIS-----GA--YLSLLQALDSRMNDLHIGCYGISD------TTIEEVFL 6578

  Fly  1164 QLNRN-GEDAGPRRPASDRSGVVAGP----------AMIT--------DEPPT----------AC 1199
            :|..| .||.......|....||..|          ..:|        |:|.|          ..
 Frog  6579 KLTDNLDEDEQDAMAWSSTKTVVPIPNEENLHVQDELSLTNYRFTDRDDQPLTNEEKLTGVSLLL 6643

  Fly  1200 KQFRLLMGKRLRHLSRNYRLLLYVLLLPALFELCAMWFVSYRLEDDFDTVLPLSRSLYPQTAQFL 1264
            |:...:..||..:..||::.|:..:|||.||.:.||...|..........|.|:..||..::|.:
 Frog  6644 KKIMAIFIKRFHNSRRNWKGLISQVLLPVLFVVIAMGLGSLSSSAVSFPELLLTPDLYGTSSQSV 6708

  Fly  1265 SHERATSFSEKL------YPQLRTSC------------------DH----LGECR---------- 1291
            :.......|..|      :|.:..||                  |:    .|.|.          
 Frog  6709 AFGLYNESSSNLVSAMNSFPGIDNSCLNQNSNCLSQNGLGLWTSDNQSLSYGSCNCSTGAPVCDA 6773

  Fly  1292 ---------------VFNTS---QQSYDWVLNSWGEYSERRYGGYGL-----------------N 1321
                           ::|.|   .:||  :|.:..::.::||||:..                 |
 Frog  6774 SSAAPPHRRTFSEQMLYNVSGYNMESY--LLTTNLQFIQKRYGGWSFGIPWVSSKLETLVPQNPN 6836

  Fly  1322 GSGATVWYNNKGYHSMMAWLNDLNSELLRTTMNDSES---SILTLNEPWKLGFAELSTSSILRQA 1383
            .:.:.||:||.|.||:.|::|..::.||||.:..:||   ||...::|......:.||:..|...
 Frog  6837 MTISKVWFNNDGPHSLPAFINSFSNFLLRTNLPSNESDQYSISVASKPLSGTVIQTSTTVTLVNT 6901

  Fly  1384 GDGSMVFILLIAFGLVVASGSVYLVNERVNGEKLQQRLCGVSAVTYWLVALVWDYLVMVLGLIVC 1448
               .:...:|..:.:..||.:.|:|.|..:|.|..|.:.||....||:...::|.::.::.:.:.
 Frog  6902 ---LIALCVLAGYSITTASFATYVVKEHHSGAKRLQHIAGVGETCYWVTNFIYDSIIYLIPVSLS 6963

  Fly  1449 LVVILMFGMPVFVDRQQLVGIIGLSLAFSFACVPSVHVAEKIFSDSSIAIVSIFCANLIV---PL 1510
            |..|.:|.:|.|.|...|..:..|.:.|.||....:::....|.....|.::....||.:   .:
 Frog  6964 LATIAIFKLPAFYDYPNLGAMSLLFILFGFATFSWMYLLAGTFKSPGNAFITYVSINLFIGINTI 7028

  Fly  1511 VTMGIILILGVVGDGPAWDDWRHALNQ-------AFLIFPIHALGDGFLELCKNYMVALVFRRYD 1568
            ::..::..| .|...|:..|:: :|||       .|.|||....|.|.:.|.:...:.:....|.
 Frog  7029 ISTSVVYFL-YVQRSPSDSDYQ-SLNQTYTVLTDVFKIFPQFCFGYGMIMLSQQQALQMQSAIYG 7091

  Fly  1569 IDSYKHPLASDLLGRHFTALLLVGVAALIINVLIEWHLLRRLWQRVER-----LLDCTYRRELDK 1628
            ..|..:..:.|:||...:|:.:.|....::.:||...::......|:|     .|..|...|.|:
 Frog  7092 GTSTTNIFSMDILGWMLSAMAIQGAFCFLLRLLINDGIIFSFKSFVKRNCMKSYLVVTKNPEEDE 7156

  Fly  1629 LGQLKLVNIQSIFKSCVDTGEA----VRAENLWLAYR---RGHYAVRNVNFSVQRGECFGLLGKN 1686
            ..:.:        :..||:|:|    ::.:.|...|.   :...||.|:..|:..||||||||.|
 Frog  7157 DVRAE--------RERVDSGQADPDLLQLQGLTKVYHHVGKNMVAVNNMTLSIPAGECFGLLGVN 7213

  Fly  1687 GAGKSTIFKLLTGQLQPDVGQIYF---------------EQPGISYCPQSNPLDPLLTTTECIRF 1736
            ||||:|.||:|||.:.|..|.|..               :.....||||.:.||.|||..|.:.|
 Frog  7214 GAGKTTTFKMLTGDVAPSKGNIQVRNNAGNLENVLGFNTDWSAFGYCPQEDALDELLTGEEHLYF 7278

  Fly  1737 YGRLRGI--RDLDQFLDRVLDTYELRPYKDVQVRNLSGGNRRKLTVAVTCCGCTPTVLMDEPTSD 1799
            |.||.||  :.:......:|...:|..|||......|.|.||||:.|:...|....:|:|||:|.
 Frog  7279 YARLHGIPEKKIKAVSFSLLQKLQLVQYKDRTTAAYSCGTRRKLSTALALIGRPSILLLDEPSSG 7343

  Fly  1800 MDPVTRDMVYATIEQLLLARRAVVLTSHSVSEIEHLCQRVAVLRAGQVIASDSPQRLKSEHGGYY 1864
            |||.|:..::..|.:.:..:.||||||||:.|.|.||.|:|::..|:.....|.|.:||..|..:
 Frog  7344 MDPKTKRHLWKIISEEVKEKCAVVLTSHSMEECEALCTRLAIMVKGKFQCIGSLQHIKSRFGSGF 7408

  Fly  1865 AVTCFCGPAQQAI--LSRSLNQRLPGA--RDLQHYAHSLRFLVRVRSPGSLGDAPLL----SELF 1921
            .|......:...:  |:..:.:..|..  :| ||:. .:.:.|.|.:.|..|...||    |:| 
 Frog  7409 TVKMHLKDSSVNVEALTSFMCRHFPNTYLKD-QHFT-MVEYHVPVTAGGVAGIFDLLEANKSDL- 7470

  Fly  1922 AILCDVCVNVARFSLSRCRFETVFERILDSSESNGSNGVHKDQQQQVA 1969
                    ::..||:|:...:.||.....|..|..::.|:..:.||.|
 Frog  7471 --------DIIHFSVSQTTLDEVFINFAQSQVSPDNSSVNSQELQQNA 7510

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
lddNP_001285513.1 rim_protein 179..1867 CDD:130324 475/1984 (24%)
abca12XP_031748843.1 rim_protein 4..>82 CDD:130324
rim_protein 5675..7493 CDD:130324 485/2028 (24%)
Blue background indicates that the domain is not in the aligned region.

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