Protein Alignment CG34120 and abca2

DIOPT Version :9

• Sequence 1: NP_001285513.1
• Gene: CG34120 / 318066
• FlyBaseID: FBgn0083956
• Length: 1998
• Species: Drosophila melanogaster
• Sequence 2: XP_031746716.1
• Gene: abca2 / 100498548
• XenbaseID: XB-GENE-969968
• Length: 2496
• Species: Xenopus tropicalis
• Alignment Length: 2323
• Identity: 508/2323 - (21%)
• Similarity: 839/2323 - (36%)
• Gaps: 702/2323 - (30%)

  Fly   106 IDVVNAFVTDERLHKAVVELAE------KANFVSAITTLI----------------TSDRFDIIR 148
            :|.|||..|..||...:.:|.|      ..:.:||:..|:                ||..|
 Frog   360 LDEVNATATQRRLQSLLEDLLEVEKILKDVDILSALAKLLPKGACASKSVLPTANSTSWGF---- 420

  Fly   149 SNISEIISLVPEIE---RRMNYSFDIKHLFSNRETFVKLGV----LLCGHPFPNTDTIPLVNEIL 206
             |.:...:...|.|   ::.....|.::..|....||:|..    :|||           :|..:
 Frog   421 -NSTSGFNFSTEAEEEAKKQEDEVDEENPRSQFSAFVQLWAGLQPILCG-----------INRTI 473

  Fly   207 ESEDFSQANDAEIDAMPTRRRRRYEDLPTDWRPTKYCKRLYRDVTSTNQGKLT-WNTIKPIIQGR 270
            |.|...|.|.:.:......:|                          |.|.|. ..|..|    :
 Frog   474 EPEALKQGNMSSLGFTSKEQR--------------------------NLGLLVHLMTSNP----K 508

  Fly   271 ILYTPANAMTESVVKFSNASFEELDRLKQ-------LSRAAATILTK--LHTNATFQEAFDN--- 323
            |||:|.....:.|::.:|.:|..:..:.:       :|.....:|.:  |.....:.:.|.|
 Frog   509 ILYSPVGTEVDKVIRKANETFAFVGNVTRYAWMWLNISAEIRGLLEEGILQRRIEWLQQFTNDLQ 573

  Fly   324 ----LLKLAKSPLVKSLVGDDFDIGEIERVFEYIRTNQLIYDILTTVADLMDCVSADRFEAVESV 384
                ||..:.|.|::.::..:|.:.....:.:.:.|   |.:........|..||.|.|:...:.
 Frog   574 KHPELLNGSDSELLRKVLSSNFTMPNASSLLQQLDT---IDNAACGWTRFMSKVSVDIFKGFPNE 635

  Fly   385 EELHKRAYELNQ----NKLFLAAL---NLEDVGL-KQASYRLHMDTDNTQPTFENRNRFWFPGPA 441
            :.:..  |.|||    |....|::   ..:|..| ....|::..::..|:.|.|.|..:|.|||.
 Frog   636 DSIVN--YTLNQAYHDNVTVFASVIFQTQKDGSLPPHVMYKIRQNSSFTEKTNEIRRAYWRPGPN 698

  Fly   442 DSMVIDLKYHRGFVQLKQMVDLGIIKSKREEAGFAPEEDGPESGRSLSGLFSIKQVENDTPDEDD 506
            ........|  |||.::.|:|..||
 Frog   699 TGGRFYFLY--GFVWIQDMMDRAII---------------------------------------- 721

  Fly   507 DDFDLSLEESGDEKAAPKVSASASDHEATTISPSSLDGVTTEEVRVTTEQTVVSGDPDLLLLKNE 571
                                                             .|:|          ..
 Frog   722 -------------------------------------------------STIV----------GH 727

  Fly   572 DVLKRSKRQGLFDLLGGFGGSGDANKKNKFEVDNMQFYTKQFPYPAFLNDVFKRGLYLAQGVQ-V 635
            ||::...                              |.:.||||.:..|.|   |::.:.:. :
 Frog   728 DVVEPGN------------------------------YVQMFPYPCYTRDDF---LFVIEHMMPL 759

  Fly   636 AYLLGLVVFVALSVRERIWMRESRNSMLMRSMGLKAHSELVAWALMSFLELCVIFALISGVLYSG 700
            ..::..|..||:.::..:..:|.|...:|:.|||......|||.:..|::|.:....::|:|..|
 Frog   760 CMVISWVYSVAMMIQHIVAEKEHRLKEVMKMMGLNNAVHWVAWFITGFVQLSISVTALTGILKYG 824

  Fly   701 GILGYTNWFFMMFYCLSFGLCLISFCYMCTNFFNSANIGAVASALLFFISLCPFIIVLMFDA--- 762
            .:|.::|.|.:..:...:.:..|.||::.:..::.|.:.:....:::|:|..|::.|.:.:.
 Frog   825 QVLMHSNVFIIWLFLSIYAVATIMFCFLVSVLYSKAKLASACGGIIYFLSYVPYMYVAIREEVAH 889

  Fly   763 -KLSVFESFLVDLSFTTAFAKGWGELIRMELQQEGLTVRHLIQVGPARSE---CAMALLMFLLDL 823
             |::.||..:..|..||||..|.......|:...|:..|...| .|...:   ..::::|.::|.
 Frog   890 DKITAFEKCIASLMSTTAFGLGSKYFALYEVAGVGIQWRTFSQ-SPVEGDDFNLMLSMMMLIIDT 953

  Fly   824 LLYAVI------------GL------AYQR-----------------YKKTDNYSFVKVSRS--- 850
            ::|.::            ||      .:||                 :.:....|.::..::
 Frog   954 MVYGILTWYIEAVHPGMYGLPRPWYFPFQRSYWLGSGRIETWEWSWPWSRPPRLSIMEEDQACAM 1018

  Fly   851 ---QLDGKLG-----------ASLVNVSKLY--GSKCAVSNLSLDFARNQVSCLLGRNGAGKSTL 899
               :||...|           ..:..::|:|  |.|.|::.|||:...|||...||.|||||:|.
 Frog  1019 ESRRLDETRGIEEEPSHLPLVVCIDKLTKIYKTGKKLALNKLSLNLHENQVVSFLGHNGAGKTTT 1083

  Fly   900 IKLLTGQIRQSSGKVLLAGEHQV-----------GVCWQDNILIPTLTAREHLQLYAQIKIPPGG 953
            :.:|||....:||...:.| |.:           |:|.|.|:|...||..|||..|:::|
 Frog  1084 MSILTGLFPPTSGSATIYG-HDIRTEMNEIRKSMGMCPQHNVLFDKLTVEEHLWFYSRLK----- 1142

  Fly   954 SGGV--EEIRSEVAQTLQSLNFGKHESYPSWQLSGGYRRRLCVAIAFIASPSVVILDEPCNGVDA 1016
              |:  ||||.|:.:.::.|............||||.:|:|.|||||:.....||||||..|||.
 Frog  1143 --GMAEEEIRKEMDKMIEDLELSNKRHSLVQTLSGGMKRKLSVAIAFVGGSKAVILDEPTAGVDP 1205

  Fly  1017 KARKDIWQLIERLRQGRAVIFATHFMDEAKYLSDSLVIMRNGRIIAQHSRDSLQRLCTSNYSIRL 1081
            .||:.||.||.:.:|||.::.:||.||||..|.|.:.|:.:|::....|...|:......|.:.:
 Frog  1206 YARRAIWDLILKYKQGRTILLSTHHMDEADLLGDRIAIISHGKLKCYGSPLFLKSTYGDGYKLTV 1270

  Fly  1082 RCADA------TGVTFVIQKAQQLLPQTQVTHSGAADYPHSLTINASY---AEHLTPGAVE--FL 1135
            ....:      ||.:.:...::..:.|....:..:...........||   :|.:..|..|  |.
 Frog  1271 VKNQSGPDTGHTGPSCISPCSEPRVSQFIKKYVASCLLVSDTNTELSYILPSESVRKGCFERLFQ 1335

  Fly  1136 ELLQSQVTAGSISDVELTT----SSSLEQEFEQLNRNGE-----------------------DAG 1173
            .|.|      ::||:|||:    .::||:.|.:::...:                       |.|
 Frog  1336 HLEQ------NLSDLELTSFGLMDTTLEEVFLKVSEEDQSLENSDADIKESKKDTLRPLIQPDGG 1394

  Fly  1174 PRRPASD-------------------------RSGVVAGPAMI---------------------- 1191
            ...|.:|                         |||..:....:
 Frog  1395 TGSPLTDALEKPEVELNNFASEAKTSQSPSSLRSGSSSSVGSVRGDEGGAYAEFYGDYSPLFDNL 1459

  Fly  1192 -------TDEPPT------------------ACKQFRLLMGKRLRHLSRNYRLLLYVLLLPALFE 1231
                   ..||.|                  ..:||..|:.||.....||.:.|...:||||.|.
 Frog  1460 QDAENLSLHEPETEEQVLDGQGSYKLEGSWLKLRQFHGLIVKRFHCAKRNTKALFSQILLPAFFV 1524

  Fly  1232 LCAMW------------------------------FVSYRLE----------------------- 1243
            ..||.                              ||.|..|
 Frog  1525 CVAMTVALSVPEIGDLPPLILSPSQYHNYTQPKGNFVPYANEEQPEYRIKLSPDAGPQQLVNTFH 1589

  Fly  1244 ----------------------------------------------DDFDTVLPLSR-------- 1254
                                                          |.|...||||.
 Frog  1590 LPSGIGATCVLKTAFNSTLDQLVQSLNMNSSESKMLAAQYFDAMCVDSFTQGLPLSNFVPPPPSP 1654

  Fly  1255 --SLYPQTAQFLSHERATSF----------------SEKLYPQLRTSCD---------------- 1285
              |.||..........||:|                ..:::..:|.:|.
 Frog  1655 APSDYPPDEDLSRLWNATTFPPEPVQAEAVTSTPSLPRRIHEPIRCTCSMQGTGFSCPSGVGGHP 1719

  Fly  1286 H-----LGECRVFNTSQQSYDWVLNSWGEYSERRYG-------------GYGLNG---------- 1322
            |     .|:..|..:.:...:::|.:...:...|||             .:|...
 Frog  1720 HQMKVVTGDIMVAISGRNVSEYLLYTSDRFRLHRYGALTFGNVQKAIPASFGAKAPPMLRKIAVR 1784

  Fly  1323 SGATVWYNNKGYHSMMAWLNDLNSELLRTTM-----NDSESSILTLNEPWKLGFAELSTSSILRQ 1382
            ..|..:|||||||||..:||.||:.|||..:     |.:...|...|.|.....|.||...:| |
 Frog  1785 HTAQAYYNNKGYHSMPTYLNALNNALLRANLPKGKGNPAAYGITVTNHPMNKTSASLSLDYLL-Q 1848

  Fly  1383 AGDGSMVFILLIAFGLVVASGSVYLVNERVNGEKLQQRLCGVSAVTYWLVALVWDYLVMVLGLIV 1447
            ..|..:...:::|...|.||..|:||.|:....|..|.:.|.:.|.|||...|||.|..::....
 Frog  1849 GTDVVIAIFIIVAMSFVPASFVVFLVAEKSTKAKHLQFVSGCNPVIYWLANYVWDMLNYLVPATC 1913

  Fly  1448 CLVVILMFGMPVFVDRQQLVGIIGLSLAFSFACVPSVHVAEKIFSDSSIAIVSIFCANLIVPL-V 1511
            |::::.:|.:|.:........::.|.|.:.::..|.::.|...|...|.|.|.:...||.:.: .
 Frog  1914 CIIILFVFDLPAYTSPTNFPAVLSLFLLYGWSITPIMYPASFWFEVPSTAYVFLIVINLFIGITA 1978

  Fly  1512 TMGIILI--------LGVVGDGPAWDDWRHALNQAFLIFPIHALGDGFLELCKNYMVALVFRRY- 1567
            |:...|:        |.:|..         .|...|||||.:.||.|.:|:..|..:...:.:.
 Frog  1979 TVATFLLQLFEHDKDLKLVNS---------YLKSCFLIFPNYNLGHGLMEMAYNEYINEYYAKIG 2034

  Fly  1568 DIDSYKHPLASDLLGRHFTALLLVGVAALIINVLIEWHLLRRLWQRVERL-----------LDCT 1621
            ..|..|.|...|::.|...|:.:.|.....|.::.::|..|    :.:||           :|..
 Frog  2035 QFDKMKSPFEWDIVTRGLVAMTIEGFVGFFITIMCQYHFFR----KPQRLPISNKPIEDDDVDVA 2095

  Fly  1622 YRRELDKLG-----QLKLVNIQSIFKSCVDTGEAVRAENLWLAYRRGH-YAVRNVNFSVQRGECF 1680
            ..|:....|     .||:.|:..::||                .:.|. .||..:...|:.||||
 Frog  2096 NERQRVLRGGADNDMLKIENLTKVYKS----------------RKMGRILAVDRLCVGVRPGECF 2144

  Fly  1681 GLLGKNGAGKSTIFKLLTGQLQPDVGQIYFE-----------QPGISYCPQSNPLDPLLTTTECI 1734
            ||||.|||||:|.||:|||......|:.:..           |..|.||||.:.|...||..|.:
 Frog  2145 GLLGVNGAGKTTTFKMLTGDESTTGGEAFINGHSILKELLQVQQTIGYCPQFDALFDELTAQEHL 2209

  Fly  1735 RFYGRLRGI--RDLDQFLDRVLDTYELRPYKDVQVRNLSGGNRRKLTVAVTCCGCTPTVLMDEPT 1797
            ..|.|||||  :|.::.:...|:..||..|.|......||||:|||:.|:...|....:.:||||
 Frog  2210 ELYTRLRGIPWKDEERVVKWALEKLELAKYADKPAGTYSGGNKRKLSTAIALIGYPSFIFLDEPT 2274

  Fly  1798 SDMDPVTRDMVYATIEQLLLARRAVVLTSHSVSEIEHLCQRVAVLRAGQVIASDSPQRLKSEHGG 1862
            :.|||..|..::..|..::...|::||||||:.|.|.||.|:|::..|::....|.|.||:..|.
 Frog  2275 TGMDPKARRFLWNLILDIIKTGRSLVLTSHSMEECEALCTRLAIMVNGRLKCLGSIQHLKNRFGD 2339

  Fly  1863 YYAVTCFCGPAQQAI----LSRSLNQRLPGARDLQHYAHSLRFLVRVRSPGSLGDAPLLSELFAI 1923
            .|.:|.   ..:.:|    :.|..|:..|.|  :....|..:...:::|. .:..|.:.|::..:
 Frog  2340 GYMITV---RTKSSINVKEVVRFFNRNFPEA--VLKERHHTKVQYQLKSE-QVSLAQVFSKMEQV 2398

  Fly  1924 LCDVCVNVARFSLSRCRFETVFERILDSSESNGSNGVHKDQQQQVAKN 1971
            | || :.:..:|:|:...:.||.........|       .:||:.|.|
 Frog  2399 L-DV-LGIEDYSVSQTTLDNVFVNFAKKQSDN-------MEQQESAPN 2437

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG34120	NP_001285513.1	ABC2_membrane_3	<621..760	CDD:289468	31/139 (22%)
		ABC_subfamily_A	859..1073	CDD:213230	86/228 (38%)
		drrA	865..1162	CDD:130256	105/326 (32%)
		ABC2_membrane_3	1230..1601	CDD:289468	111/554 (20%)
		Mem_trans	1436..>1552	CDD:304621	29/124 (23%)
		ABC_subfamily_A	1651..1857	CDD:213230	80/219 (37%)
		drrA	1666..1945	CDD:130256	98/295 (33%)
abca2	XP_031746716.1	rim_protein	1..2430	CDD:130324	504/2314 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	143	1.000	Domainoid score	I4610
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D131191at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920