DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment stg1 and Cacng3

DIOPT Version :9

Sequence 1:	NP_001027082.1	Gene:	stg1 / 318064	FlyBaseID:	FBgn0064123	Length:	447	Species:	Drosophila melanogaster
Sequence 2:	NP_062303.2	Gene:	Cacng3 / 54376	MGIID:	1859165	Length:	315	Species:	Mus musculus

Alignment Length:	231	Identity:	65/231 - (28%)
Similarity:	98/231 - (42%)	Gaps:	42/231 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   217 MTTVNGGYLWLITPVAASISVAIVIAALAGPQWLFTEEKLPNANYNGTANFKALDDGAYITK--- 278
            |...:.|...|||.|.|..:.:::..|:....||::         .|....|:..|.....|
Mouse     1 MRMCDRGIQMLITTVGAFAAFSLMTIAVGTDYWLYS---------RGVCRTKSTSDNETSRKNEE 56

  Fly   279 -YTKSSLWILCTTLPGLDADSYNCVKIDYFSNEG-YQPDPHDSTAAIPYTVTKSCPIFLAAGVFL 341
             .|.|.||..| .|.|  |....|.|||:|..:. |:.|    ||.......:      |:.||.
Mouse    57 VMTHSGLWRTC-CLEG--AFRGVCKKIDHFPEDADYEQD----TAEYLLRAVR------ASSVFP 108

  Fly   342 VISF-IVFLIPTCSHQNNLY------YFSAGILFIVSGLVMLIGLIAYISILKAEIGSKLRPRST 399
            ::|. ::|....|...:..:      ..||||.|:.:||..:||:|.|||....:.|.:...:|
Mouse   109 ILSVTLLFFGGLCVAASEFHRSRHSVILSAGIFFVSAGLSNIIGIIVYISANAGDPGQRDSKKS- 172

  Fly   400 LQPALIKVSYGQSFFLFVFGFIVTEFVGVLNIFLFI 435
                   .|||.||:...|.||:.|.|||:.:.::|
Mouse   173 -------YSYGWSFYFGAFSFIIAEIVGVVAVHIYI 201

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
stg1	NP_001027082.1	PMP22_Claudin	235..429	CDD:304458	56/205 (27%)
Cacng3	NP_062303.2	PMP22_Claudin	6..196	CDD:419754	63/219 (29%)
Cacng3	NP_062303.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	232..253
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	59	1.000	Domainoid score	I10601
eggNOG	1	0.900	-	-		E1_28M76
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000345
OrthoInspector	1	1.000	-	-		otm43441
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12107
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	7	6.870