DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment stg1 and CACNG2

DIOPT Version :9

Sequence 1:	NP_001027082.1	Gene:	stg1 / 318064	FlyBaseID:	FBgn0064123	Length:	447	Species:	Drosophila melanogaster
Sequence 2:	NP_006069.1	Gene:	CACNG2 / 10369	HGNCID:	1406	Length:	323	Species:	Homo sapiens

Alignment Length:	233	Identity:	63/233 - (27%)
Similarity:	96/233 - (41%)	Gaps:	55/233 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   223 GYLWLITPVAASISVAIVIAALAGPQWLFTEEKLPNANYNGTANFKALDDGAYITK----YTKSS 283
            |...|:|.|.|..:.:::..|:....||::         .|....|::.:.....|    .|.|.
Human     7 GVQMLLTTVGAFAAFSLMTIAVGTDYWLYS---------RGVCKTKSVSENETSKKNEEVMTHSG 62

  Fly   284 LWILCT---TLPGLDADSYNCVKIDYFSNEG-YQPDPHDSTAAIPYTVTKSCPIFL----AAGVF 340
            ||..|.   ...||      |.:||:|..:. |:.|              :...||    |:.:|
Human    63 LWRTCCLEGNFKGL------CKQIDHFPEDADYEAD--------------TAEYFLRAVRASSIF 107

  Fly   341 LVISFI-VFLIPTCSHQNNLY------YFSAGILFIVSGLVMLIGLIAYISILKAEIGSKLRPRS 398
            .::|.| :|:...|...:..|      ..||||.|:.:||..:||:|.|||   |..|...:..|
Human   108 PILSVILLFMGGLCIAASEFYKTRHNIILSAGIFFVSAGLSNIIGIIVYIS---ANAGDPSKSDS 169

  Fly   399 TLQPALIKVSYGQSFFLFVFGFIVTEFVGVLNIFLFIN 436
            ...    ..|||.||:.....||:.|.||||.:.:||:
Human   170 KKN----SYSYGWSFYFGALSFIIAEMVGVLAVHMFID 203

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
stg1	NP_001027082.1	PMP22_Claudin	235..429	CDD:304458	54/212 (25%)
CACNG2	NP_006069.1	PMP22_Claudin	6..197	CDD:395662	60/225 (27%)
CACNG2	NP_006069.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	233..261
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	57	1.000	Domainoid score	I10855
eggNOG	1	0.900	-	-		E1_28M76
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000345
OrthoInspector	1	1.000	-	-		otm41386
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12107
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	7	6.870