DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment stg1 and cacng8b

DIOPT Version :9

Sequence 1:	NP_001027082.1	Gene:	stg1 / 318064	FlyBaseID:	FBgn0064123	Length:	447	Species:	Drosophila melanogaster
Sequence 2:	XP_001342922.4	Gene:	cacng8b / 100003329	ZFINID:	ZDB-GENE-100921-72	Length:	422	Species:	Danio rerio

Alignment Length:	220	Identity:	64/220 - (29%)
Similarity:	96/220 - (43%)	Gaps:	32/220 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   227 LITPVAASISVAIVIAALAGPQWLFTEEKLPNANYNGTA----NFKALDDGAYITKYTKSSLWIL 287
            |:|.|.|..|..::..|:....||::...:.|:..|.|.    |....|.||    .|.|.||.:
Zfish    10 LLTIVGAFASFGLMTVAIGTDYWLYSRALICNSTANNTQEDPHNKDKKDPGA----LTHSGLWRI 70

  Fly   288 CTTLPGLDADSYNCVKIDYFSNEGYQPDPHDSTAAIPYTVTKSCPIFLAAGVFLVISFIVFLI-P 351
            | .|.|:....  |.:|::|..:.  ...||....:...|.       |:.:|.::|.|:.|: .
Zfish    71 C-CLEGVKRGV--CSQINHFPEDA--DFDHDGAEYVLRVVR-------ASNIFPILSAILLLMGG 123

  Fly   352 TCSHQNNLY------YFSAGILFIVSGLVMLIGLIAYISILKAEIGSKLRPRSTLQPALIKVSYG 410
            .|...:..|      ...|||||:.:||..:||:|.|||....:|..|.......|     .|||
Zfish   124 VCIAASRFYKSKRNIVLGAGILFVAAGLSNIIGVIVYISAALGDISPKKDEDKKWQ-----YSYG 183

  Fly   411 QSFFLFVFGFIVTEFVGVLNIFLFI 435
            .||:.....||:.|.||||.:.::|
Zfish   184 WSFYFGGLSFILAEMVGVLAVNIYI 208

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
stg1	NP_001027082.1	PMP22_Claudin	235..429	CDD:304458	57/204 (28%)
cacng8b	XP_001342922.4	PMP22_Claudin	5..203	CDD:328820	62/213 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170577604
Domainoid	1	1.000	66	1.000	Domainoid score	I9896
eggNOG	1	0.900	-	-		E1_28M76
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000345
OrthoInspector	1	1.000	-	-		otm24542
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12107
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5605
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	9	8.830