DRSC/TRiP Functional Genomics Resources

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Protein Alignment tbc and RABGAP1L

DIOPT Version :9

Sequence 1:NP_001285494.1 Gene:tbc / 318059 FlyBaseID:FBgn0052506 Length:1155 Species:Drosophila melanogaster
Sequence 2:NP_001353375.1 Gene:RABGAP1L / 9910 HGNCID:24663 Length:1051 Species:Homo sapiens


Alignment Length:799 Identity:151/799 - (18%)
Similarity:262/799 - (32%) Gaps:276/799 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly   446 SVMESVDETPID---YV-------FRIVSKSRHEEFAA--THSILDFVRSTPRRAQLSSCSTTGS 498
            :.|:|..:.|..   ||       .||:.:|.:.|.|:  .:.:|...|......: |:|.....
Human   156 ATMKSSSQYPFPVTLYVPNVPEGSVRIIDQSSNVEIASFPIYKVLFCARGHDGTTE-SNCFAFTE 219

  Fly   499 SDCSNKSLSIDQFPMESPLILQQQQQQQQQLLQAQSTSIEMVCSTMRRQIISRAFYGWLAYCRHL 563
            |...::...|..|..|              :.:|.|..:...|:..:|.            .|.:
Human   220 SSHGSEEFQIHVFSCE--------------IKEAVSRILYSFCTAFKRS------------SRQV 258

  Fly   564 STVRTHLSGLVHGRITPEMKADEEGLTKERWQLLNVNGVLENATEFYRLVYFGGVQPELRQEVWP 628
            |.|:        ..:.|...:|                           |:...|..|::::.  
Human   259 SDVK--------DSVIPTPDSD---------------------------VFTFSVSLEVKEDD-- 286

  Fly   629 YLLGHYAFGSTTEDRKKQDETCKHYYETTMSEWLAVDAIVQQREKEKTA--RAVAKLSSGSNSGN 691
               |...|....:||.      |.|::........|...|||...::.|  |....|.|...:..
Human   287 ---GKGNFSPVPKDRD------KFYFKLKQGIEKKVVITVQQLSNKELAIERCFGMLLSPGRNVK 342

  Fly   692 DRTVRAADLEAGG---DLENEVFEDISDISDPGDLEFDEQQQQQQQQAECAVSGNHLT--VKPIP 751
            :..:...|:|:.|   |....|...:.:.:.|..|..:|:..:.:|..........:|  |:|:.
Human   343 NSDMHLLDMESMGKSYDGRAYVITGMWNPNAPVFLALNEETPKDKQVYMTVAVDMVVTEVVEPVR 407

  Fly   752 -----------------------------RAMKTSTDSGHVD--ESFNELDEPDEEDNKQK---- 781
                                         ..:|.|...||.:  ::..|:.....|.:|::    
Human   408 FLLETVVRVYPANERFWYFSRKTFTETFFMRLKQSEGKGHTNAGDAIYEVVSLQRESDKEEPVTP 472

  Fly   782 --------QQQDEKISESESKLP----DYRKLEEQINQEPSCSASTASSY-ETVGP--GEVHQRP 831
                    .|.||...||:::|.    |..|         .|......|: |.:|.  ..:..||
Human   473 TSGGGPMSPQDDEAEEESDNELSSGTGDVSK---------DCPEKILYSWGELLGKWHSNLGARP 528

  Fly   832 NSDTRSVLS--PEYLSADDLQL----PDDE---DAVRPPPPPAAAAVIITKASVDITNWERSPKA 887
            ...:..|.|  ||.|.|:..||    .|::   |..|         ::|||.|.     :.|...
Human   529 KGLSTLVKSGVPEALRAEVWQLLAGCHDNQAMLDRYR---------ILITKDSA-----QESVIT 579

  Fly   888 AEGDQMSPLEEQAGESGGAGVNMDALQQPKSACASPASSNGGVYSSELLEQFGLNLHRIEKDVQR 952
            .:..:..|..:...::||.|                                             
Human   580 RDIHRTFPAHDYFKDTGGDG--------------------------------------------- 599

  Fly   953 CDRNYWYFANENLDKLRNVISTYVWEHLDVGYMQGMCDLVAPLLVIFDDESLSYSCFCKLMERMI 1017
                     .|:|.|:....|.|   ..|:||.||...|.|.||:...:|    ..||.|::.|.
Human   600 ---------QESLYKICKAYSVY---DEDIGYCQGQSFLAAVLLLHMPEE----QAFCVLVKIMY 648

  Fly  1018 E---------NFPSGGAMDMHFANMRSLIQILDSEMYDLMDSNGDYTHF--------YFCYRWFL 1065
            :         ||.     |:| .....|.:::..::.||      ::||        .:..:|||
Human   649 DYGLRDLYRNNFE-----DLH-CKFYQLERLMQEQLPDL------HSHFSDLNLEAHMYASQWFL 701

  Fly  1066 LDFKRELVYDDVFATWEVIWAAKHIASGHFVLF-LALALLETYRDIILSNSMDFTDVIKFFN-EM 1128
            ..|..:.....||...:::     :..|..::| :|||||:|.::.:|  ..||...:|||. ::
Human   702 TLFTAKFPLCMVFHIIDLL-----LCEGLNIIFHVALALLKTSKEDLL--QADFEGALKFFRVQL 759

  Fly  1129 AERHNAQSVLQLARSLVLQ 1147
            .:|:.|:   :.||.|:.|
Human   760 PKRYRAE---ENARRLMEQ 775

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
tbcNP_001285494.1 RUN 45..218 CDD:280855
PH_RUTBC 292..466 CDD:275431 7/29 (24%)
TBC 923..1087 CDD:214540 34/180 (19%)
RABGAP1LNP_001353375.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..52
PTB_Rab6GAP 129..257 CDD:269922 22/127 (17%)
DUF3694 290..421 CDD:315198 25/136 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 461..503 9/41 (22%)
RabGAP-TBC 541..744 CDD:306939 59/294 (20%)
DUF3084 800..>1018 CDD:331293
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5210
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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