Protein Alignment tbc and SGSM2

DIOPT Version :9

• Sequence 1: NP_001285494.1
• Gene: tbc / 318059
• FlyBaseID: FBgn0052506
• Length: 1155
• Species: Drosophila melanogaster
• Sequence 2: XP_011522403.1
• Gene: SGSM2 / 9905
• HGNCID: 29026
• Length: 1103
• Species: Homo sapiens
• Alignment Length: 1258
• Identity: 493/1258 - (39%)
• Similarity: 673/1258 - (53%)
• Gaps: 300/1258 - (23%)

  Fly     4 GNADGSDYKERLIASVKKEVKQLMEEAVTKKYVHEESSSVTSLC--------------------- 47
            |:|:.: .||:|:.:|||||||:||||||:|:|||:||.:.:||
Human     2 GSAEDA-VKEKLLWNVKKEVKQIMEEAVTRKFVHEDSSHIIALCAADPHQGLTRCQTPFTVQGNG 65

  Fly    48 -------------------------GAVEACLSQGLRRRALGLFKTSSTTALLHKIAKSCPEAEH 87
                                     .||||||...|||||.|..::....||..|:.|:||.|..
Human    66 SDKMDRVSAAGAYILLGRQTGNKCASAVEACLLHQLRRRAAGFLRSDKMAALFTKVGKTCPVAGE 130

  Fly    88 ISKLVQEI-EASDPSKRSSSSSDSFQRPPMLKKSSSNSMSTGTNAAASTSSASASISVSASTSSM 151
            |...|||: :.::..|.|..|.::.:|..                           |.|....::
Human   131 ICHKVQELQQQAEGRKPSGVSQEALRRQG---------------------------SASGKAPAL 168

  Fly   152 SLASMKYLWIRLALYEKRLTKIIEYLVSNASSFYDRDSLVADSDYGSILSSLLVGPCALEFTRAK 216
            |..::|::|:|.||.||.|.|:::||..|.|.:|::::|:||..:|.||:||||||||||:|:.|
Human   169 SPQALKHVWVRTALIEKVLDKVVQYLAENCSKYYEKEALLADPVFGPILASLLVGPCALEYTKLK 233

  Fly   217 TADHYWTDPHADELVQRHRI-SSCRRSSSTCSRPAIINFKRSLNTSSDEAGTGSFKSIASASVAK 280
            |||||||||.|||||||||| ....|..|...|||:...||.        .:||......|:.|:
Human   234 TADHYWTDPSADELVQRHRIRGPPTRQDSPAKRPALGIRKRH--------SSGSASEDRLAACAR 290

  Fly   281 DYVESLHQNAKATLLYGKNNVQVLPKDVAEPMPGYLSLHQHIQTLTIKWTPNQLMNGYTEAEEAE 345
            :.|||||||::..||||||:|.|.||:..|.:||||||||..::||:||||||||||.....|
Human   291 ECVESLHQNSRTRLLYGKNHVLVQPKEDMEAVPGYLSLHQSAESLTLKWTPNQLMNGTLGDSE-- 353

  Fly   346 DIDKDAFWAYALNINVDEIVYVHCHQSRGEDSGGTVILVGQDGVQRPPIHFPEGGHMQQFLSCLE 410
             ::|..:|.|||.:...::|.:||||.:   ||||::||.|||:||||:|||:|||:..||||||
Human   354 -LEKSVYWDYALVVPFSQVVCIHCHQQK---SGGTLVLVSQDGIQRPPLHFPQGGHLLSFLSCLE 414

  Fly   411 TGLLPHGQLDPPLWSQRGIGKMFLWPRSMRRRILPSV-MESVDE-TPIDYVFRIVSKS-RHEEF- 471
            .||||.|||:||||:|:|.||:|  |:..:|..:.|| ||.:.. ...||||||:... |||..
Human   415 NGLLPRGQLEPPLWTQQGKGKVF--PKLRKRSSIRSVDMEEMGTGRATDYVFRIIYPGHRHEHIT 477

  Fly   472 ----------AAT-----------HSILDFVRS------------------------------TP 485
                      ||:           |::|..:.|                              .|
Human   478 INYHHLAASRAASVDDDEEEEDKLHAMLSMICSRNLTAPNPMKDAGDMIEMQGFGPSLPAWHLEP 542

  Fly   486 RRAQLSSCSTTGSSDC-----SNKSLSIDQFPMESPLILQQQQQQQQQLLQAQSTSIEMVCSTMR 545
            ..:|.|||.:..||..     |:.|...|:.|                        :.::|.:|:
Human   543 LCSQGSSCLSCSSSSSPHATPSHCSCIPDRLP------------------------LRLLCESMK 583

  Fly   546 RQIISRAFYGWLAYCRHLSTVRTHLSGLVHGRITPEMK--ADEEGLTKERWQLLNVNGVLENATE 608
            |||:|||||||||:||||||||||||.|||..:.|..:  ....||||:.|.....:.......|
Human   584 RQIVSRAFYGWLAHCRHLSTVRTHLSALVHHSVIPPDRPPGASAGLTKDVWSKYQKDKKNYKELE 648

  Fly   609 FYRLVYFGGVQPELRQEVWPYLLGHYAFGSTTEDRKKQDETCKHYYETTMSEWLAVDAIVQQREK 673
            ..|.||:||::.|:|::|||:|||||.||.:.::.::.|......|:..::||.|.:.:|:|||:
Human   649 LLRQVYYGGIEHEIRKDVWPFLLGHYKFGMSKKEMEQVDAVVAARYQQVLAEWKACEVVVRQRER 713

  Fly   674 EKTARAVAKLSSGSNSGNDRTVRAADLEAGGDLENEVFEDISDISDPGDLEFDEQQQQQQQQAEC 738
            |.......|.||||:.  |..|:.. :.....:.|:||..:.|:..|...:.::.:.:.:|:|..
Human   714 EAHPATRTKFSSGSSI--DSHVQRL-IHRDSTISNDVFISVDDLEPPEPQDPEDSRPKPEQEAGP 775

  Fly   739 AVSGNHLTVKPIPRAMKTSTDSGHVDESFN-ELDEPDEEDNKQKQQQDEKISESESKLPDYRKLE 802
            ...|..:                 |::..: |.|.||                  |.||..|...
Human   776 GTPGTAV-----------------VEQQHSVEFDSPD------------------SGLPSSRNYS 805

  Fly   803 EQINQEPSCSASTASSYE---------TVGPGEVHQRPNSDTRSVLSPEYLSADDLQLPDDEDAV 858
            .....:.|.....:..:|         :.|||.                  :|..|:.|.|....
Human   806 VASGIQSSLDEGQSVGFEEEDGGGEEGSSGPGP------------------AAHTLREPQDPSQE 852

  Fly   859 RPPPPPAAAAVIITKASVDITNWERSPKAAEGDQMSPLEEQAGESGGAGVNMDALQQPKSACASP 923
            :|                                      ||||       ::|.::..:.||:
Human   853 KP--------------------------------------QAGE-------LEAGEELAAVCAA- 871

  Fly   924 ASSNGGVYSSELLEQFGLNLHRIEKDVQRCDRNYWYFANENLDKLRNVISTYVWEHLDVGYMQGM 988
                  .|:.|||:...||||||:|||||||||||||...||::||:|:.:||||||||||:|||
Human   872 ------AYTIELLDTVALNLHRIDKDVQRCDRNYWYFTPPNLERLRDVMCSYVWEHLDVGYVQGM 930

  Fly   989 CDLVAPLLVIFDDESLSYSCFCKLMERMIENFPSGGAMDMHFANMRSLIQILDSEMYDLMDSNGD 1053
            |||:|||||..|::.|:||||..||:||.:|||:|||||.|||||||||||||||:::||..|||
Human   931 CDLLAPLLVTLDNDQLAYSCFSHLMKRMSQNFPNGGAMDTHFANMRSLIQILDSELFELMHQNGD 995

  Fly  1054 YTHFYFCYRWFLLDFKRELVYDDVFATWEVIWAAKHIASGHFVLFLALALLETYRDIILSNSMDF 1118
            |||||||||||||||||||:|:||||.|||||||:||:|.|||||:||||:|.||:||..|:|||
Human   996 YTHFYFCYRWFLLDFKRELLYEDVFAVWEVIWAARHISSEHFVLFIALALVEAYREIIRDNNMDF 1060

  Fly  1119 TDVIKFFNEMAERH-NAQSVLQL 1140
            ||:|||||.:   | :.|:||.:
Human  1061 TDIIKFFNAL---HVSPQNVLSI 1080

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tbc	NP_001285494.1	RUN	45..218	CDD:280855	64/219 (29%)
		PH_RUTBC	292..466	CDD:275431	95/175 (54%)
		TBC	923..1087	CDD:214540	116/163 (71%)
SGSM2	XP_011522403.1	RUN	90..235	CDD:280855	62/171 (36%)
		PH_RUTBC	302..470	CDD:275431	95/175 (54%)
		TBC	<885..1053	CDD:214540	127/167 (76%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	297	1.000	Domainoid score	I1464
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48923
OrthoDB	1	1.010	-	-		D171826at2759
OrthoFinder	1	1.000	-	-		FOG0002045
OrthoInspector	1	1.000	-	-		mtm8482
orthoMCL	1	0.900	-	-		OOG6_103962
Panther	1	1.100	-	-	O	PTHR22957
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3416
SonicParanoid	1	1.000	-	-		X1347
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.820