Protein Alignment tbc and Sgsm2

DIOPT Version :10

• Sequence 1: NP_608395.6
• Gene: tbc / 318059
• FlyBaseID: FBgn0052506
• Length: 1155
• Species: Drosophila melanogaster
• Sequence 2: NP_001361617.1
• Gene: Sgsm2 / 97761
• MGIID: 2144695
• Length: 1050
• Species: Mus musculus
• Alignment Length: 1217
• Identity: 514/1217 - (42%)
• Similarity: 692/1217 - (56%)
• Gaps: 233/1217 - (19%)

  Fly     4 GNADGSDYKERLIASVKKEVKQLMEEAVTKKYVHEESSSVTSLCGAVEACLSQGLRRRALGLFKT 68
            |:|:.: .||:|:.:|||||||:||||||:|:|||:||.:.:|||||||||...|||||.|..::
Mouse     2 GSAEDA-VKEKLLWNVKKEVKQIMEEAVTRKFVHEDSSHIIALCGAVEACLLHQLRRRAAGFLRS 65

  Fly    69 SSTTALLHKIAKSCPEAEHISKLVQEIEASDPSKRSSSSSDSFQRPPMLKKSSSNSMSTGTNAAA 133
            ....||..|:.|:||.||.|...|||::.....::.|..|..     .|:|..    |||..|.|
Mouse    66 DKMAALFTKVGKTCPVAEDICHKVQELQQQAEGRKPSGGSQE-----ALRKQG----STGGKAPA 121

  Fly   134 STSSASASISVSASTSSMSLASMKYLWIRLALYEKRLTKIIEYLVSNASSFYDRDSLVADSDYGS 198
                             :|..::|::|:|.||.||.|.::::||..|.|.:|::::|:||..:|.
Mouse   122 -----------------LSPQALKHIWVRTALMEKVLDRVVQYLAENCSKYYEKEALLADPVFGP 169

  Fly   199 ILSSLLVGPCALEFTRAKTADHYWTDPHADELVQRHRI-SSCRRSSSTCSRPAIINFKRSLNTSS 262
            ||:.|||||||||:|:.||||||||||.|||||||||| ....|..|...|||:...||.
Mouse   170 ILACLLVGPCALEYTKLKTADHYWTDPSADELVQRHRIRGPPNRQDSPAKRPALGIRKRH----- 229

  Fly   263 DEAGTGSFKSIASASVAKDYVESLHQNAKATLLYGKNNVQVLPKDVAEPMPGYLSLHQHIQTLTI 327
               .:||......|:.|::||||||||::..||||||||.|.||:..|.:||||||||..:.||:
Mouse   230 ---SSGSASEDRLAACAREYVESLHQNSRTRLLYGKNNVLVQPKEDMEAVPGYLSLHQSAENLTL 291

  Fly   328 KWTPNQLMNGYTEAEEAEDIDKDAFWAYALNINVDEIVYVHCHQSRGEDSGGTVILVGQDGVQRP 392
            ||||||||||.....|   ::|..:|.|||.:...:||.:||||.:   ||||::||.|||:|||
Mouse   292 KWTPNQLMNGTLGDSE---LEKSVYWDYALVVPFSQIVCIHCHQQK---SGGTLVLVSQDGIQRP 350

  Fly   393 PIHFPEGGHMQQFLSCLETGLLPHGQLDPPLWSQRGIGKMFLWPRSMRRRILPSVMESVDETPI- 456
            |:|||:|||:..||||||.||||.|||:||||:|:|.||:|  |:..:|..:.|:  .|:|..:
Mouse   351 PLHFPQGGHLLSFLSCLENGLLPRGQLEPPLWTQQGKGKVF--PKLRKRSSIRSI--DVEELGVG 411

  Fly   457 ---DYVFRIVSKS-RHEEF-----------AAT-----------HSILDFVRS------------ 483
               ||||||:... |||..           ||:           |::|..:.|
Mouse   412 RATDYVFRIIYPGHRHEHITINYHHLAASRAASVDDDEEEEDKLHAMLSMICSRNLTAPNPMKDA 476

  Fly   484 ------------------TPRRAQLSSCSTTGSSDC-----SNKSLSIDQFPMESPLILQQQQQQ 525
                              .|..:|.|||.:..||..     |:.|...|:.|
Mouse   477 GDMIEMQGFGPSLTAWHLEPLCSQGSSCLSCSSSSSPYATPSHCSCIPDRLP------------- 528

  Fly   526 QQQLLQAQSTSIEMVCSTMRRQIISRAFYGWLAYCRHLSTVRTHLSGLVHGRITPEMK--ADEEG 588
                       :.::|.:|:|||:||||||||||||||||||||||.|||..|.|..:  ....|
Mouse   529 -----------LRLLCESMKRQIVSRAFYGWLAYCRHLSTVRTHLSALVHHNIIPPDRPPGASGG 582

  Fly   589 LTKERWQLLNVNGVLENATEFYRLVYFGGVQPELRQEVWPYLLGHYAFGSTTEDRKKQDETCKHY 653
            |||:.|.....:.......|..|.||:|||:.|:|::|||:|||||.||.:.::.::.|......
Mouse   583 LTKDVWSKYQKDEKNYKELELLRQVYYGGVEHEIRKDVWPFLLGHYKFGMSKKEMEQVDTAVAAR 647

  Fly   654 YETTMSEWLAVDAIVQQREKEKTARAVAKLSSGSNSGNDRTVRAADLEAGGDLENEVFEDISDIS 718
            |:..::||.|.:.:|:|||:|.....:.|.||||:.  |..|:.. :.....:.|:||..:.|:.
Mouse   648 YQQVLAEWKACEVVVRQREREAHPATLTKFSSGSSI--DSHVQRL-VHRDSTISNDVFISVDDLE 709

  Fly   719 DPGDLEFDEQQQQQQQQAECAVSGNHLTVKPIPRAMKTSTDSGHVDESFNELDEPDEEDNKQKQQ 783
            ..|..:.::.:.:::|:......|       |..|.:.|.          |.|.||
Mouse   710 PSGPQDLEDSKPKREQEPGAGTPG-------IAAAEQQSV----------EFDSPD--------- 748

  Fly   784 QDEKISESESKLPDYRKLEEQINQEPSCSASTASSYETVGPGEVHQRPNSDTRSVLSPEYLSADD 848
                     |.||..|........:.|...:.:..:|..|.||
Mouse   749 ---------SGLPSSRNYSVASGIQSSLDEAQSVGFEDDGAGE---------------------- 782

  Fly   849 LQLPDDEDAVRPPPPPAAAAVIITKASVDITNWERSPKAAEGDQMSPLEEQAGESGGAGVNMDAL 913
                |..:.      ||.||....           .|.....:.::|..|           ::|.
Mouse   783 ----DGSEG------PATAAHTFP-----------GPHDPGQETLAPASE-----------LEAG 815

  Fly   914 QQPKSACASPASSNGGVYSSELLEQFGLNLHRIEKDVQRCDRNYWYFANENLDKLRNVISTYVWE 978
            |:..:.||:       .|:.|||:...||||||:|||||||||||||...||::||:::.:||||
Mouse   816 QELAAVCAA-------AYTIELLDTVALNLHRIDKDVQRCDRNYWYFTTSNLERLRDIMCSYVWE 873

  Fly   979 HLDVGYMQGMCDLVAPLLVIFDDESLSYSCFCKLMERMIENFPSGGAMDMHFANMRSLIQILDSE 1043
            |||:||:||||||:||||||.|::.|:||||..||:||.:|||||||||.|||||||||||||||
Mouse   874 HLDMGYVQGMCDLLAPLLVILDNDQLAYSCFSHLMKRMGQNFPSGGAMDSHFANMRSLIQILDSE 938

  Fly  1044 MYDLMDSNGDYTHFYFCYRWFLLDFKRELVYDDVFATWEVIWAAKHIASGHFVLFLALALLETYR 1108
            :::||..||||||||||||||||||||||:|:||||.|||||||:.|:|.|||||:||||:|.||
Mouse   939 LFELMHQNGDYTHFYFCYRWFLLDFKRELLYEDVFAVWEVIWAARRISSEHFVLFIALALVEAYR 1003

  Fly  1109 DIILSNSMDFTDVIKFFNEMAERHNAQSVLQLARSLVLQLQMIIENK 1155
            :||..|:|||||:||||||.||||:||.:|::||.||.::||:|:||
Mouse  1004 EIIRDNNMDFTDIIKFFNERAERHDAQEILRIARDLVHKVQMLIDNK 1050

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tbc	NP_608395.6	RUN_SGSM1_like	21..214	CDD:439049	82/192 (43%)
		PH_RUTBC	292..466	CDD:275431	96/177 (54%)
		TBC	923..1087	CDD:214540	116/163 (71%)
Sgsm2	NP_001361617.1	RUN_SGSM2	18..197	CDD:439066	92/204 (45%)
		PH_RUTBC	256..424	CDD:275431	96/177 (54%)
		TBC	<838..1006	CDD:214540	126/167 (75%)