DRSC/TRiP Functional Genomics Resources

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Protein Alignment tbc and Sgsm2

DIOPT Version :9

Sequence 1:NP_001285494.1 Gene:tbc / 318059 FlyBaseID:FBgn0052506 Length:1155 Species:Drosophila melanogaster
Sequence 2:NP_001361617.1 Gene:Sgsm2 / 97761 MGIID:2144695 Length:1050 Species:Mus musculus


Alignment Length:1217 Identity:514/1217 - (42%)
Similarity:692/1217 - (56%) Gaps:233/1217 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 GNADGSDYKERLIASVKKEVKQLMEEAVTKKYVHEESSSVTSLCGAVEACLSQGLRRRALGLFKT 68
            |:|:.: .||:|:.:|||||||:||||||:|:|||:||.:.:|||||||||...|||||.|..::
Mouse     2 GSAEDA-VKEKLLWNVKKEVKQIMEEAVTRKFVHEDSSHIIALCGAVEACLLHQLRRRAAGFLRS 65

  Fly    69 SSTTALLHKIAKSCPEAEHISKLVQEIEASDPSKRSSSSSDSFQRPPMLKKSSSNSMSTGTNAAA 133
            ....||..|:.|:||.||.|...|||::.....::.|..|..     .|:|..    |||..|.|
Mouse    66 DKMAALFTKVGKTCPVAEDICHKVQELQQQAEGRKPSGGSQE-----ALRKQG----STGGKAPA 121

  Fly   134 STSSASASISVSASTSSMSLASMKYLWIRLALYEKRLTKIIEYLVSNASSFYDRDSLVADSDYGS 198
                             :|..::|::|:|.||.||.|.::::||..|.|.:|::::|:||..:|.
Mouse   122 -----------------LSPQALKHIWVRTALMEKVLDRVVQYLAENCSKYYEKEALLADPVFGP 169

  Fly   199 ILSSLLVGPCALEFTRAKTADHYWTDPHADELVQRHRI-SSCRRSSSTCSRPAIINFKRSLNTSS 262
            ||:.|||||||||:|:.||||||||||.|||||||||| ....|..|...|||:...||.     
Mouse   170 ILACLLVGPCALEYTKLKTADHYWTDPSADELVQRHRIRGPPNRQDSPAKRPALGIRKRH----- 229

  Fly   263 DEAGTGSFKSIASASVAKDYVESLHQNAKATLLYGKNNVQVLPKDVAEPMPGYLSLHQHIQTLTI 327
               .:||......|:.|::||||||||::..||||||||.|.||:..|.:||||||||..:.||:
Mouse   230 ---SSGSASEDRLAACAREYVESLHQNSRTRLLYGKNNVLVQPKEDMEAVPGYLSLHQSAENLTL 291

  Fly   328 KWTPNQLMNGYTEAEEAEDIDKDAFWAYALNINVDEIVYVHCHQSRGEDSGGTVILVGQDGVQRP 392
            ||||||||||.....|   ::|..:|.|||.:...:||.:||||.:   ||||::||.|||:|||
Mouse   292 KWTPNQLMNGTLGDSE---LEKSVYWDYALVVPFSQIVCIHCHQQK---SGGTLVLVSQDGIQRP 350

  Fly   393 PIHFPEGGHMQQFLSCLETGLLPHGQLDPPLWSQRGIGKMFLWPRSMRRRILPSVMESVDETPI- 456
            |:|||:|||:..||||||.||||.|||:||||:|:|.||:|  |:..:|..:.|:  .|:|..: 
Mouse   351 PLHFPQGGHLLSFLSCLENGLLPRGQLEPPLWTQQGKGKVF--PKLRKRSSIRSI--DVEELGVG 411

  Fly   457 ---DYVFRIVSKS-RHEEF-----------AAT-----------HSILDFVRS------------ 483
               ||||||:... |||..           ||:           |::|..:.|            
Mouse   412 RATDYVFRIIYPGHRHEHITINYHHLAASRAASVDDDEEEEDKLHAMLSMICSRNLTAPNPMKDA 476

  Fly   484 ------------------TPRRAQLSSCSTTGSSDC-----SNKSLSIDQFPMESPLILQQQQQQ 525
                              .|..:|.|||.:..||..     |:.|...|:.|             
Mouse   477 GDMIEMQGFGPSLTAWHLEPLCSQGSSCLSCSSSSSPYATPSHCSCIPDRLP------------- 528

  Fly   526 QQQLLQAQSTSIEMVCSTMRRQIISRAFYGWLAYCRHLSTVRTHLSGLVHGRITPEMK--ADEEG 588
                       :.::|.:|:|||:||||||||||||||||||||||.|||..|.|..:  ....|
Mouse   529 -----------LRLLCESMKRQIVSRAFYGWLAYCRHLSTVRTHLSALVHHNIIPPDRPPGASGG 582

  Fly   589 LTKERWQLLNVNGVLENATEFYRLVYFGGVQPELRQEVWPYLLGHYAFGSTTEDRKKQDETCKHY 653
            |||:.|.....:.......|..|.||:|||:.|:|::|||:|||||.||.:.::.::.|......
Mouse   583 LTKDVWSKYQKDEKNYKELELLRQVYYGGVEHEIRKDVWPFLLGHYKFGMSKKEMEQVDTAVAAR 647

  Fly   654 YETTMSEWLAVDAIVQQREKEKTARAVAKLSSGSNSGNDRTVRAADLEAGGDLENEVFEDISDIS 718
            |:..::||.|.:.:|:|||:|.....:.|.||||:.  |..|:.. :.....:.|:||..:.|:.
Mouse   648 YQQVLAEWKACEVVVRQREREAHPATLTKFSSGSSI--DSHVQRL-VHRDSTISNDVFISVDDLE 709

  Fly   719 DPGDLEFDEQQQQQQQQAECAVSGNHLTVKPIPRAMKTSTDSGHVDESFNELDEPDEEDNKQKQQ 783
            ..|..:.::.:.:::|:......|       |..|.:.|.          |.|.||         
Mouse   710 PSGPQDLEDSKPKREQEPGAGTPG-------IAAAEQQSV----------EFDSPD--------- 748

  Fly   784 QDEKISESESKLPDYRKLEEQINQEPSCSASTASSYETVGPGEVHQRPNSDTRSVLSPEYLSADD 848
                     |.||..|........:.|...:.:..:|..|.||                      
Mouse   749 ---------SGLPSSRNYSVASGIQSSLDEAQSVGFEDDGAGE---------------------- 782

  Fly   849 LQLPDDEDAVRPPPPPAAAAVIITKASVDITNWERSPKAAEGDQMSPLEEQAGESGGAGVNMDAL 913
                |..:.      ||.||....           .|.....:.::|..|           ::|.
Mouse   783 ----DGSEG------PATAAHTFP-----------GPHDPGQETLAPASE-----------LEAG 815

  Fly   914 QQPKSACASPASSNGGVYSSELLEQFGLNLHRIEKDVQRCDRNYWYFANENLDKLRNVISTYVWE 978
            |:..:.||:       .|:.|||:...||||||:|||||||||||||...||::||:::.:||||
Mouse   816 QELAAVCAA-------AYTIELLDTVALNLHRIDKDVQRCDRNYWYFTTSNLERLRDIMCSYVWE 873

  Fly   979 HLDVGYMQGMCDLVAPLLVIFDDESLSYSCFCKLMERMIENFPSGGAMDMHFANMRSLIQILDSE 1043
            |||:||:||||||:||||||.|::.|:||||..||:||.:|||||||||.|||||||||||||||
Mouse   874 HLDMGYVQGMCDLLAPLLVILDNDQLAYSCFSHLMKRMGQNFPSGGAMDSHFANMRSLIQILDSE 938

  Fly  1044 MYDLMDSNGDYTHFYFCYRWFLLDFKRELVYDDVFATWEVIWAAKHIASGHFVLFLALALLETYR 1108
            :::||..||||||||||||||||||||||:|:||||.|||||||:.|:|.|||||:||||:|.||
Mouse   939 LFELMHQNGDYTHFYFCYRWFLLDFKRELLYEDVFAVWEVIWAARRISSEHFVLFIALALVEAYR 1003

  Fly  1109 DIILSNSMDFTDVIKFFNEMAERHNAQSVLQLARSLVLQLQMIIENK 1155
            :||..|:|||||:||||||.||||:||.:|::||.||.::||:|:||
Mouse  1004 EIIRDNNMDFTDIIKFFNERAERHDAQEILRIARDLVHKVQMLIDNK 1050

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
tbcNP_001285494.1 RUN 45..218 CDD:280855 67/172 (39%)
PH_RUTBC 292..466 CDD:275431 96/177 (54%)
TBC 923..1087 CDD:214540 116/163 (71%)
Sgsm2NP_001361617.1 RUN 42..185 CDD:367169 65/168 (39%)
PH_RUTBC 256..424 CDD:275431 96/177 (54%)
TBC <838..1006 CDD:214540 126/167 (75%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 297 1.000 Domainoid score I1458
eggNOG 1 0.900 - - E1_COG5210
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG48923
OrthoDB 1 1.010 - - D171826at2759
OrthoFinder 1 1.000 - - FOG0002045
OrthoInspector 1 1.000 - - mtm8717
orthoMCL 1 0.900 - - OOG6_103962
Panther 1 1.100 - - O PTHR22957
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3416
SonicParanoid 1 1.000 - - X1347
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
1312.820

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