DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tbc and GYP5

DIOPT Version :9

Sequence 1:	NP_001285494.1	Gene:	tbc / 318059	FlyBaseID:	FBgn0052506	Length:	1155	Species:	Drosophila melanogaster
Sequence 2:	NP_015075.1	Gene:	GYP5 / 855827	SGDID:	S000006170	Length:	894	Species:	Saccharomyces cerevisiae

Alignment Length:	755	Identity:	145/755 - (19%)
Similarity:	266/755 - (35%)	Gaps:	206/755 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   497 GSSDCSNKSLSIDQF------PMESPLILQQQQQQQQQLLQAQSTSIEMVCSTMRRQIISRAFYG 555
            ||.:...||...||:      |.| ||...::...:|     ||...|...:..|.:.|.
Yeast    29 GSMEEEIKSTPSDQYEEIAIIPTE-PLHSDKELNDKQ-----QSLGHEAPTNVSREEPIG----- 82

  Fly   556 WLAYCRHLSTVRTHLSGLVHGRITPEMKADEEGLTKERWQLLNVNGVLENATEFYRLVYFGGVQP 620
                          :||....:||.:...::...|:|....:::|..|:             |:.
Yeast    83 --------------ISGDEDTQITEQNVNEQRQETREPSSEIDLNEPLD-------------VEK 120

  Fly   621 ELRQEVWPYLLGHYAFGSTTE---DRKKQDETCKHYYETTMSEWLAVDAIVQQREKEKTARAVAK 682
            ::..:|      ....|...|   |..|::|  |.|.:|.       :.:.....:|.|
Yeast   121 DVTTDV------QAPNGLNIEKEYDAVKENE--KVYADTK-------EVVSSPENREVT------ 164

  Fly   683 LSSGSNSGNDR--TVRAADLEAGG---------DLENEVFEDISDISD----------PGDLEFD 726
               |.|||.::  :.:..|.|:|.         .:.:||..:.|..:|          ...:..:
Yeast   165 ---GKNSGGEKSSSSKFLDDESGTTTAANANDISISSEVTPERSSENDNNQIHITNEVAAGINLN 226

  Fly   727 EQQQQQQQQAECAVSGNHLT------VKPIPRAMKTSTDSGHVDESFNELDE---------PDEE 776
            |.::|:....:..|:..:|:      |.|||  .:...:.|. :.|.||:..         |..:
Yeast   227 ENKEQKAAIEDGPVTAENLSSETARKVPPIP--TQIINEKGD-NSSENEVSAIPTTSSPPLPPRQ 288

  Fly   777 D------------NKQKQQQDEKIS------ESESKLPDYRKLEEQINQE-----PSCSASTA-- 816
            :            .||::|..:..:      |.|.|...:||..|:..:.     |...:.||
Yeast   289 NVATSTSPKLPPRGKQREQPPKTKNAVPPPLEEEMKSEKFRKNFEETKRNSYHHVPLTGSKTAQL 353

  Fly   817 ---------------SSYETVGPGEVHQRPNSDTRSVLSPEYLS-------ADDLQLPDDEDAVR 859
                           :|:.....||..:....:.:|.|...:.|       .::::..::||.
Yeast   354 ESTAEINLIASRYRKTSHHLNKEGEETRESLQEGQSFLKSTFTSFLENLSEYNEVENVNEEDR-- 416

  Fly   860 PPPPPAAAAVIITKASVDITNW-----------ERSPKAAEGDQMSPLEEQAGESGGAGVNMDAL 913
                        ....:|.:.|           ...|:..|....:.:..|.     .|:....:
Yeast   417 ------------EMFKIDWSFWTQVVNDYATVASNEPENLEAHVTNGIPPQI-----RGIIWQLM 464

  Fly   914 QQPKSACASPASSNGGVYSSELLEQFGLNLHRIEKDVQRCDRNYWYFANENLDKLRNVISTYVWE 978
            ...||      .....:|.: ||:...|:...|.:|::|..    :.|.:.::.|..||..|...
Yeast   465 ANSKS------REMEDIYET-LLDTECLHEATIRRDLRRTK----FVAEDKMESLYKVIKVYSVY 518

  Fly   979 HLDVGYMQGMCDLVAPLLVIFDDESLSYSCFCKLMER--MIENFPSG--GAMDMHFANMRSLIQI 1039
            ..||||.|||..:.||||:..::|:.|:.....||:.  :.|.|..|  |.|.|.:...| |::.
Yeast   519 DPDVGYTQGMGFIAAPLLINCENEAESFGLLVGLMKNYGLRELFLPGMPGLMLMLYQFDR-LLEE 582

  Fly  1040 LDSEMYDLMDSNGDYTHFYFCYRWFLLDFKRELVYDDVFATWEVIWAAKHIASGHFVLFLALALL 1104
            ....:|:.:...|..:..| ..:|||..|..:...:.|...:::::.........|.:.|.|...
Yeast   583 HSPSLYNRLIREGISSTMY-ATQWFLTFFAYKFPLEFVLRIFDIVFVEGIEVLLKFAVNLMLKNE 646

  Fly  1105 ETYRDIILSNSMDF-TDVIKFFNEMAERHNAQSVLQLARS 1143
            ||...:.....:|| .|.:..:..|..:.:| ||:|:..|
Yeast   647 ETLVKLRFDELLDFLKDELFNYYLMGNQDDA-SVVQMGLS 685

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tbc	NP_001285494.1	RUN	45..218	CDD:280855
		PH_RUTBC	292..466	CDD:275431
		TBC	923..1087	CDD:214540	43/167 (26%)
GYP5	NP_015075.1	COG5210	154..737	CDD:227535	111/577 (19%)
GYP5	NP_015075.1	SMC_prok_B	726..>891	CDD:274008
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900