DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tbc and GYL1

DIOPT Version :9

Sequence 1:	NP_001285494.1	Gene:	tbc / 318059	FlyBaseID:	FBgn0052506	Length:	1155	Species:	Drosophila melanogaster
Sequence 2:	NP_013917.1	Gene:	GYL1 / 855230	SGDID:	S000004804	Length:	720	Species:	Saccharomyces cerevisiae

Alignment Length:	766	Identity:	155/766 - (20%)
Similarity:	267/766 - (34%)	Gaps:	209/766 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 EAVTKKYVHEESSSVTSLCGAVEACLSQGLRRRALGLFKTSSTTALLHKIAKS--CPEAEHISKL 91
            ||:.:..:.|||.|.|.|   ....|||.|..      :.|.....|.:|...  .|.|:.|.:.
Yeast    82 EALMQSKLREESQSKTIL---PSDDLSQQLET------EESKVEEALKRITSPPLPPRADCIEES 137

  Fly    92 VQEIEASDP-----SKRSSSSSDSFQRPP--MLKKSSSNSMSTGTNAAASTSSASASISVSAST- 148
            ...:::|.|     :|...:..|..|.||  ::...:.:..:...||..|.|..||..:.|:||
Yeast   138 ASALKSSLPPVLAGNKNDQAPLDRPQLPPRQVVNAETLHLKAPHGNATPSKSPTSAVGNSSSSTP 202

  Fly   149 ---------SSMSLASMKYLWIRLALYEKRLTKIIEYLVSNASSFYDRDSLVADSDYGSILSSLL 204
                     ..:.||:.|:.                     .:|.:.|:.|...|:..||
Yeast   203 PTLPPRRIEDPLDLAAQKHF---------------------LASTFKRNMLFYKSEDNSI----- 241

  Fly   205 VGPCALEFTRAKTADHYWTDPHADELVQRHRISSCRRSSSTCSRPAIINFK---RSLNTSSDEAG 266
              .|.|:                                     ..|:|.|   :.:|.:.....
Yeast   242 --KCDLD-------------------------------------KNILNLKEDSKKINNNEIPEE 267

  Fly   267 TGSFKSIASASVAKDY-------VESLH-QNAKA-----------TLLYGKNN----------VQ 302
            ..||    ...|..||       :|:|| |.::.           .:.|.|:.          .:
Yeast   268 VSSF----WLKVIGDYQNILINDIETLHFQLSRGIPAAYRLVVWQLVSYAKSKSFDPIYETYLTE 328

  Fly   303 VLPKDVAEPMPGYLSLHQHIQTLTIKWTPNQLMNGY----TEAEEAEDIDKDAFWAYALNINVDE 363
            :.|.||.| ....|.:...:.:..:|...| ::..|    .|.|.:.||      ||.:|:.:|.
Yeast   329 MAPFDVQE-FENQLKMMDEVPSEYVKRISN-VLKAYLLFDPECEFSTDI------AYIINMILDV 385

  Fly   364 IVYVHCHQSRGEDSGGTVILVGQDGVQRPPIHFPEGGHMQQFLSCLETGLLPHGQLDPPLWS--- 425
                 | :......|..|.|:...|::.  :..|....:.  :.|.:...|.. :..|.:.:
Yeast   386 -----C-EEEANAFGLLVRLMKVYGLRL--LFLPSASEID--ILCYKFDRLVE-EFYPEIHNHMV 439

  Fly   426 QRGI-GKMF-------LWPRSMRRRILPSVMESVDETPIDYVFRI----VSKSR-HEEFAATHSI 477
            ::|: ..||       |:.:.:...|.|.:.:.|....||.:.||    :|.|| |........:
Yeast   440 EKGVRSSMFLPGFFTTLFQKKLPTEIQPRIGDMVFLEGIDSIMRILATLLSNSRDHLLKMGFDDM 504

  Fly   478 LDFVRSTPRRAQL-SSCSTTG----SSDCSNKSLSIDQFPME-SPLILQQQQQQQQQLLQAQSTS 536
            |:.::|....|.: .:..|.|    |::|.:|.|......:. :|..:::...:.:::.:..:..
Yeast   505 LELLKSGLLDAYIKQNDGTRGDTLLSNECMDKLLQDSMMKVAITPKTMKKYSSEYEEIHRLDNEK 569

  Fly   537 IEMVCSTMRRQIISRAFYGWLAYCRHLSTVRTHLSGLVHGRITPEMKADEEGLTKERWQLLNVNG 601
            .....|...:.         |...:|:..:....:.|....:|   .|:|  |.|.|   ||:..
Yeast   570 EVQYKSITEKN---------LHLQKHVRKLENDYTSLNREHVT---IANE--LVKNR---LNIES 617

  Fly   602 VLENATEFYRLVYFGGVQPELRQEVWPYLLGHYAFGSTTEDRKKQ-DETCKHYYETTMSEWLAVD 665
            || |....|:|... .::.:|..|....:||.|    ...|.||. :||.|...: .|.|.|.:.
Yeast   618 VL-NENNGYKLQIL-DLKKKLDSEKKKQVLGVY----VPNDLKKDLEETMKKNTQ-VMDENLKLQ 675

  Fly   666 AIVQQREK----EKTARAVAKLSSGSNSGNDRTVRAADLEAGGDLENEVFE 712
            ..:.:.|:    .|||.....|...|||.|:      .|.||.....:||:
Yeast   676 DRISELERLIEEIKTANKNGTLFEYSNSKNN------PLGAGWSGFKKVFK 720

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tbc	NP_001285494.1	RUN	45..218	CDD:280855	38/191 (20%)
		PH_RUTBC	292..466	CDD:275431	39/213 (18%)
		TBC	923..1087	CDD:214540
GYL1	NP_013917.1	COG5210	27..569	CDD:227535	110/583 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900