DRSC/TRiP Functional Genomics Resources

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Protein Alignment tbc and MSB4

DIOPT Version :10

Sequence 1:NP_608395.6 Gene:tbc / 318059 FlyBaseID:FBgn0052506 Length:1155 Species:Drosophila melanogaster
Sequence 2:NP_014529.1 Gene:MSB4 / 854037 SGDID:S000005472 Length:492 Species:Saccharomyces cerevisiae


Alignment Length:465 Identity:81/465 - (17%)
Similarity:149/465 - (32%) Gaps:129/465 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly   766 SFNE----------LDEPDEEDNKQKQQQDEKISESE-SKLPDYRKL----EEQINQEPSCSAST 815
            ||||          .|:.||.|:....::.|.::..| .|...:..|    .|..::........
Yeast    25 SFNEDDANYSVLDLYDDDDEGDDSSTVERKEILTTRELEKAKAFTSLIMADPENFDRYGFSKKGY 89

  Fly   816 ASSYETVGPGEVHQRPNSDTRSVLSPEYLSADDLQLPDDEDAVRPPPPPAAAAVIITKASVDITN 880
            ..|.|............::.|......:|..:.::|.:|...|.|                    
Yeast    90 FISQEEYDKWWTEYNRYTERRKKKWENFLLKNKIELHNDNPLVYP-------------------- 134

  Fly   881 WERSPKAAEGDQMS-------PLEEQ-------AGESGGAGVNMDALQQPKSACASPASSNGGVY 931
                   |..|::|       |.|.:       ||.......|:....:.||.|...|.|     
Yeast   135 -------ARTDELSKFVRKGIPAEWRGNAWWYFAGGQRQLDANVGVYDRLKSDCREGAVS----- 187

  Fly   932 SSELLEQFGLNLHRIEKDVQRCDRNYWYFANEN--------LDKLRNVISTYVWEHLDVGYMQGM 988
                    |.::..||:|:.|...:..:|..|:        :..||.|:..:......:||.|.|
Yeast   188 --------GKDMEAIERDLYRTFPDNIHFHKESFQNGEPAIIRSLRRVLMAFSVYDKTIGYCQSM 244

  Fly   989 CDLVAPLLVIFDDESLSYSCFCKLMERMIENFPSGGAMDMHFANMRSLIQILDSEMY-------- 1045
            ..||..||:..::|    ..|..|:....:..|.....|:..||:...:.:|..:.|        
Yeast   245 NFLVGLLLLFMEEE----KAFWMLVIITGKYLPGVYESDLEGANVDQGVLVLCIKEYLPEIWSHI 305

  Fly  1046 --DLMDSNGDYTHF--------YFC---------YRWFLLDFKRELVYDDVFATWEVIWAAKHIA 1091
              ..|:.||.....        |.|         ..||:..|...:..:.....|:.::    ..
Yeast   306 ESSYMNGNGSTDQISGPASGEEYLCRLPTLTLCTASWFMSCFVGVVPIETTLRIWDCLF----YE 366

  Fly  1092 SGHFVLFLALALLETYRDIILSNSMDFTDVIKFFNEMAE-----RHNAQSVLQLARSLV------ 1145
            ..||:..:||.:|:......|.:...     |.|.:.:.     .:::.|..:..::.:      
Yeast   367 ESHFLFKVALGILKLSESEFLESKSQ-----KLFRQYSSYTFGGSNDSDSTFKRLKNKIKTQEEA 426

  Fly  1146 -LQLQMIIEN 1154
             :::..:|:|
Yeast   427 DMEILQVIQN 436

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
tbcNP_608395.6 RUN_SGSM1_like 21..214 CDD:439049
PH_RUTBC 292..466 CDD:275431
TBC 923..1087 CDD:214540 38/198 (19%)
MSB4NP_014529.1 COG5210 <53..461 CDD:227535 73/437 (17%)
Blue background indicates that the domain is not in the aligned region.

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