Protein Alignment tbc and GYP7

DIOPT Version :10

• Sequence 1: NP_608395.6
• Gene: tbc / 318059
• FlyBaseID: FBgn0052506
• Length: 1155
• Species: Drosophila melanogaster
• Sequence 2: NP_010047.1
• Gene: GYP7 / 851364
• SGDID: S000002393
• Length: 746
• Species: Saccharomyces cerevisiae
• Alignment Length: 646
• Identity: 149/646 - (23%)
• Similarity: 242/646 - (37%)
• Gaps: 203/646 - (31%)

  Fly   600 NGVLENATEFYRLV-YFGGVQPELRQEVWPYLLGH-YAFGSTTEDRKKQDETCKHYYETTMSEWL 662
            ||....:...|.|. .|.|.||       |.|..| ....|||:..|:..::...:.::....|.
Yeast   112 NGWYVGSLVIYPLTEQFTGFQP-------PVLFFHDQLCPSTTDKLKRLRKSMNPFDDSDELYWG 169

  Fly   663 AVD---AIVQQREKEKT----------------ARAVAK--LSSGSNSGNDRTVRAADLEAGGDL 706
            .||   .|.:..|.:|:                ...|:|  |.|.:||..|.|    :|...|..
Yeast   170 GVDLRNKINELMELKKSNLEPEFWLVNPSLNDLRNFVSKDLLESYNNSKKDTT----ELATAGVK 230

  Fly   707 ENEVFED-----ISDISDPGDLEFDEQQQQQQQQAECAVSGNHLTVKPIPRAMKTSTDSGHVDES 766
            .||.|::     :|.|:|                                    .:|.|.:..:|
Yeast   231 LNEKFQEWKWNVMSKIAD------------------------------------VTTKSTNFIDS 259

  Fly   767 FNELDEPDEE---DNK--QKQQQDEKISESESKLPDYRKLEEQINQEPSCSASTASSYETVG--- 823
            :...:.|.::   ||:  ||...:||:.:.|.   ||.            ||....:..::|
Yeast   260 WLTNNSPIQKSQIDNEYLQKLLNNEKVKQIEQ---DYD------------SARVYLANWSLGVKQ 309

  Fly   824 PGEVHQRPNSDTRSVLSPEYLS--ADDLQLPDD------EDAVRPPPPPAAAAVIITKASVDITN 880
            ..|.:|:.|.     |...|.:  .:||.|.|:      .:|::...|       :|:|..: :.
Yeast   310 EAERYQKQNK-----LFDSYRNNIFNDLNLTDELSDTEINNALQRQFP-------LTEAKWN-SL 361

  Fly   881 WERSPKAAEGDQMSPLEEQAGESGGAGVNMDALQ---------------------QPKSACASPA 924
            |:.:    :|.....:.|........|:..|:|:                     |.....|:..
Yeast   362 WDEN----DGRLRVTVNEVKDFIFHGGLENDSLRGKVWGFLLEIYPWDSSQDERVQIDQTLAAEY 422

  Fly   925 SSNGGVYSSELL--------EQFGLNLHRIEKDVQRCDRNYWYF----------------ANEN- 964
            ......:|.:.|        |.:...|.||.|||:|||||...|                ||||
Yeast   423 DQLKLTWSKDFLQFDDEDEEEYWNDQLFRISKDVRRCDRNLEIFQYNTIDGLPPPPQQLPANENN 487

  Fly   965 ----------------------LDKLRNVISTYVWEHLDVGYMQGMCDLVAPLLVIFDDESLSYS 1007
                                  |..|:|::.||...:.::||:|||.||::|:.||..:|..::.
Yeast   488 STSPESANDESDDADDGVRNPHLIHLQNILITYNVYNTNLGYVQGMTDLLSPIYVIMKEEWKTFW 552

  Fly  1008 CFCKLMERMIENF---PSGGAMDMHFANMRSLIQILDSEMYDLMD--SNGDYTHFYFCYRWFLLD 1067
            ||...|:.|..||   .||    :| ..|.:|::::...:.:|.:  :..|..:.:||:|..|:.
Yeast   553 CFTHFMDIMERNFLRDQSG----IH-EQMLTLVELVQLMLPELSEHLNKCDSGNLFFCFRMLLVW 612

  Fly  1068 FKRELVYDDVFATWEVIWAAKHIASGHFVLFLALALLETYRDIILSNSMDFTDVIKFFNEM 1128
            ||||...:|:...||..|...:  |..|.||..||:|:.....||.:...|..::|||||:
Yeast   613 FKREFEMEDIMHIWENFWTFYY--SSQFQLFFMLAILQKNSQAILQHLNQFDQILKFFNEL 671

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tbc	NP_608395.6	RUN_SGSM1_like	21..214	CDD:439049
		PH_RUTBC	292..466	CDD:275431
		TBC	923..1087	CDD:214540	60/215 (28%)
GYP7	NP_010047.1	COG5210	134..738	CDD:227535	141/617 (23%)