DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tbc and TBC1D10A

DIOPT Version :9

Sequence 1:	NP_001285494.1	Gene:	tbc / 318059	FlyBaseID:	FBgn0052506	Length:	1155	Species:	Drosophila melanogaster
Sequence 2:	NP_001191169.1	Gene:	TBC1D10A / 83874	HGNCID:	23609	Length:	515	Species:	Homo sapiens

Alignment Length:	339	Identity:	58/339 - (17%)
Similarity:	101/339 - (29%)	Gaps:	135/339 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly   879 TNWERSPKA-AEGDQMSPLEEQAGESGGAGVNMDALQQPKSACASPASSNGGVYSSELLEQFGL- 941
            :|.|..|:| |.|:.:|...|...: |......|.|    |:..|.:.:||  ::...:::||.
Human     4 SNGENGPRAPAAGESLSGTRESLAQ-GPDAATTDEL----SSLGSDSEANG--FAERRIDKFGFI 61

  Fly   942 ------------NLHRIEK---DVQRCDRNYWYFANENLDK------------------------ 967
                        .|||:|:   :|.|...:.|.....|.||
Human    62 VGSQGAEGAPCPLLHRLEEVPLEVLRQRESKWLDMLNNWDKWMAKKHKKIRLRCQKGIPPSLRGR 126

  Fly   968 -----------------------------------------------------------LRNVIS 973
                                                                       |..|:.
Human   127 AWQYLSGGKVKLQQNPGKFDELDMSPGDPKWLDVIERDLHRQFPFHEMFVSRGGHGQQDLFRVLK 191

  Fly   974 TYVWEHLDVGYMQGMCDLVAPLLVIFDDESLSYSCFCKLMERMIENFPSGGAMDMHFANMRSLIQ 1038
            .|.....:.||.|....:.|.||:....|. ::.|..::.|:.:..:         ::.....||
Human   192 AYTLYRPEEGYCQAQAPIAAVLLMHMPAEQ-AFWCLVQICEKYLPGY---------YSEKLEAIQ 246

  Fly  1039 ILDSE-MYDLMDSNGDYTH----------FYFCYRWFLLDFKRELVYDDVFATWEVIWAAKHIAS 1092
             ||.| ::.|:.......|          ..:...||:..|.|.|.:..|...|::.:     ..
Human   247 -LDGEILFSLLQKVSPVAHKHLSRQKIDPLLYMTEWFMCAFSRTLPWSSVLRVWDMFF-----CE 305

  Fly  1093 GHFVLF-LALALLE 1105
            |..::| :.|.||:
Human   306 GVKIIFRVGLVLLK 319

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tbc	NP_001285494.1	RUN	45..218	CDD:280855
		PH_RUTBC	292..466	CDD:275431
		TBC	923..1087	CDD:214540	40/273 (15%)
TBC1D10A	NP_001191169.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..46		13/46 (28%)
		TBC	117..320	CDD:214540	31/219 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	403..515
		ZipA	<403..>502	CDD:331990
		Binding to the PDZ domain of EBP50	512..515
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900