DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tbc and AT5G52580

DIOPT Version :9

Sequence 1:	NP_001285494.1	Gene:	tbc / 318059	FlyBaseID:	FBgn0052506	Length:	1155	Species:	Drosophila melanogaster
Sequence 2:	NP_001190524.1	Gene:	AT5G52580 / 835335	AraportID:	AT5G52580	Length:	690	Species:	Arabidopsis thaliana

Alignment Length:	962	Identity:	190/962 - (19%)
Similarity:	327/962 - (33%)	Gaps:	383/962 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly   258 LNTSSDEAGTGSFKSIASASV-----AKDYVESLHQNAKATLLYGKNNVQVLPKDVA-EPMPGYL 316
            |...||:|...:.:...|||:     .|..::|.|::  |.|:|.|:||.:.|...| |.:.|.|
plant     8 LQDLSDDADYAASQQQGSASMMRSDSGKRSLQSEHED--AVLIYLKDNVAIHPTQFASERISGRL 70

  Fly   317 SLHQHIQTLTIKWTPNQLMNGYTEAEEAEDIDKDAFWAYALNINVDEIVYVHCH-QSRGEDSGGT 380
            .|.:....|.:.|.|   ..|.|...:..:.|:..:...|  :...|:..:..| .:.|..   .
plant    71 KLTKQDSVLFLSWIP---YKGQTSNAKLSEKDRSLYTITA--VPFTEVRSIRRHTPALGWQ---Y 127

  Fly   381 VILVGQDGVQRPPIHFPEGGHMQQFLSCL-----------ETGLLPHGQLDPPLWSQRGIGKMFL 434
            ||:|...|:..||::|..|| :::||:.:           :..:........||  ||.:..:.|
plant   128 VIVVLSSGLAFPPLYFYNGG-VREFLAMVKQHVFLARSSEDQNVFIVNDFQSPL--QRTLSSLEL 189

  Fly   435 ---WPRSMRRRILP----SVMESVDETPIDYVFRIVSKSRH-------------------EEFAA 473
               .|.:..:.:.|    |..|:...|..|...|:.|.|:.                   |:|:.
plant   190 PSSLPVASGQSVYPLDGGSSSENQRRTSSDVGNRVSSVSQSGFRKQKSHDPTRDLSIHLLEKFSL 254

  Fly   474 THSILDFVRSTPRRAQLSSCSTTGSSDCSNKSLSIDQFPMESPLILQQQQQQ------QQQLLQA 532
               :..|.|.|..:. .|..:..||.|....:..:..:|.:...|.:::..:      :..||:.
plant   255 ---VTKFARDTTTQL-FSENNGFGSIDKRWNNQPVHSYPEKLSNIAEEKHHEIRHSYSENDLLKD 315

  Fly   533 QSTS-IEMVCSTMRRQIISRAFYGWLAYCRHLSTVRTHLSGLVHGR--------------ITPEM 582
            ...| |::....:....:|                      |:.|:              |:|.:
plant   316 DEISYIDVPADPLEFDKLS----------------------LMWGKPRQPPMGHKERRNDISPSI 358

  Fly   583 KA--DEEGLTKERWQLLNVNGVLENATEFYRLVYFGGVQPELRQEVWPYLLGHYAFGSTTEDRKK 645
            |.  ..|..|    .||:..|.:..:......|::||::.:||:||||:|||:||:.||..:|
plant   359 KCRISTEYFT----ALLDSEGRVVESKALRERVFYGGIEHQLRREVWPFLLGYYAYDSTYAER-- 417

  Fly   646 QDETCKHYYETTMSEWLAVDAIVQQREKEKTARAVAKLSSGSNSGNDRTVRAADLEAGGDLENEV 710
                          |:|                              |:|:.
plant   418 --------------EYL------------------------------RSVKR------------- 425

  Fly   711 FEDISDISDPGDLEFDEQQQQQQQQAECAVSGNHLTVKPIPRAMKTSTDSGHVDESFNELDEPDE 775
                        :|:...:||.|            ::.|
plant   426 ------------MEYATLKQQWQ------------SISP-------------------------- 440

  Fly   776 EDNKQKQQQDEKISESESKLPDYRKLEEQINQEPSCSASTASSYETVGPGEVHQRPNSDTRSVLS 840
                          |...:...||
plant   441 --------------EQAKRFTKYR----------------------------------------- 450

  Fly   841 PEYLSADDLQLPDDEDAVRPPPPPAAAAVIITKASVDITNWERSPKAAEGDQMSPLEEQAGESGG 905

plant   451 ----------------------------------------------------------------- 450

  Fly   906 AGVNMDALQQPKSACASPASSNGGVYSSELLEQFGLNLHRIEKDVQRCDRNYWYFA---NENLDK 967
                                           |:.||    |:|||.|.||.:.|:.   |.:::.
plant   451 -------------------------------ERKGL----IDKDVVRTDRAFEYYEGDDNLHVNS 480

  Fly   968 LRNVISTYVWEHLDVGYMQGMCDLVAPLLVIFDDESLSYSCFCKLMERMIENF--PSGGAMDMHF 1030
            :|:::.||.:.:.|:||.|||.|.::|:|.:.:|||.|:.||..||||:..||  ...|.....|
plant   481 MRDILLTYSFYNFDLGYCQGMSDYLSPILFVMEDESESFWCFVALMERLGPNFNRDQNGMHTQLF 545

  Fly  1031 ANMRSLIQILDSEMYDLMDSNGDYTHFYFCYRWFLLDFKRELVYDDVFATWEVIWAAKHIASGHF 1095
            | :..|:::|||.:::....| |..:::||:||.|:.||||..|:.....|||:|.  |..|.||
plant   546 A-LSKLVELLDSPLHNYFKEN-DCLNYFFCFRWILIQFKREFEYEKTMQLWEVMWT--HYLSEHF 606

  Fly  1096 VLFLALALLETYRDIILSNSMDFTDVIKFFNEMAERHNAQSVLQLARSLVLQ 1147
            .|::.:|:|:..|..|:...|||..::||.||::...:..|.::.|.:|.::
plant   607 HLYVCVAVLKRCRSKIMGEQMDFDTLLKFINELSGHIDLDSTVRDAEALCIE 658

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tbc	NP_001285494.1	RUN	45..218	CDD:280855
		PH_RUTBC	292..466	CDD:275431	46/193 (24%)
		TBC	923..1087	CDD:214540	59/168 (35%)
AT5G52580	NP_001190524.1	DUF3548	47..183	CDD:192931	35/146 (24%)
AT5G52580	NP_001190524.1	TBC	388..623	CDD:214540	95/502 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	237	1.000	Inparanoid score	I1101
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22957
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.960