DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tbc and AT5G24390

DIOPT Version :9

Sequence 1:	NP_001285494.1	Gene:	tbc / 318059	FlyBaseID:	FBgn0052506	Length:	1155	Species:	Drosophila melanogaster
Sequence 2:	NP_197827.1	Gene:	AT5G24390 / 832510	AraportID:	AT5G24390	Length:	528	Species:	Arabidopsis thaliana

Alignment Length:	602	Identity:	119/602 - (19%)
Similarity:	210/602 - (34%)	Gaps:	176/602 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   589 LTKERW-QLLNVNGVLEN-ATEFYRLVYFGGVQPELRQEVWPYLLGHYAFGSTTEDRKKQDETCK 651
            ||..|| :.....|.:.| ..:..:.|...|:.|.:|.||||:|||...|.|:.|:|.......:
plant    63 LTLRRWRRCFTPEGRIRNGGVDLLKKVRTRGIDPSIRSEVWPFLLGVCDFNSSEEERGATRTWRR 127

  Fly   652 HYYETTMSEWLAVDAIVQQREKEKTARAVAKLSSGS---NSGNDRTVRAADLEAGGDLENEVFED 713
            ..||                ...:..:.:.|.:||:   |..|..|
plant   128 KVYE----------------RLRRQCKRLQKQNSGTFKLNKINKTT------------------- 157

  Fly   714 ISDISDPGDLEFDEQQQQQQQQAECAVSGNHLTVKPIPRAMKTST-DSGHVDESFNELDEPDEED 777
                   .|.|.|.....|..::.|  |.:..:|.....:.|.:| |.|::.:....|   |.:.
plant   158 -------QDDEHDSWSLAQDSESSC--SDDACSVHESLISDKDNTEDIGYMSDVSCTL---DRDY 210

  Fly   778 NKQKQQQDEKISESESKLPDYRKLEEQINQEPSCSASTASSYETVGPGEVHQRPNSDTRSVLSPE 842
            |..:....|......|...||      :...|||...
plant   211 NGSRHLNSESSDSDSSDENDY------VQVAPSCEGK---------------------------- 241

  Fly   843 YLSADDLQLPDDEDAVRPPPPPAAAAVIITKASVDITNWERSPKAAEGDQMSPLEEQAGESGGAG 907
                       ||::..|      :::.|::...|...|:|.
plant   242 -----------DENSTSP------SSIYISRTKEDFVTWQRI----------------------- 266

  Fly   908 VNMDALQ-----QPKSACASPASSNGGVYSSELLEQFGLNLHRIEKDVQRCDRNYWYFANENL-- 965
            :.:|||:     .|.|...:..|.|....::|.:   ||             ::|.|.....:
plant   267 IRLDALRADTEWTPYSQSQALVSENRARRAAEAV---GL-------------KDYSYLEPSKIFH 315

  Fly   966 -DKLRNVISTYVWEHLDVGYMQGMCDLVAPLLVIFDDESLSYSCFCKLMERMIENF---PSGGAM 1026
             .:|..|:..|.....::||.|||.||::|:|.:..|:..::.||...|::..:||   ..|...
plant   316 AARLVAVLEAYALHDPEIGYCQGMSDLLSPILSVIPDDYEAFWCFVGFMKKARQNFRVDEVGITR 380

  Fly  1027 DMHFANMRSLIQILDSEMYDLMDSNGDYTHFYFCYRWFLLDFKRELVYDDVFATWEVIWAAK-HI 1090
            .::..:  .:|:..||::|..:: .......:|.||..|:.|:|||..:.....||||||.: .|
plant   381 QLNIVS--KIIKSKDSQLYKHLE-KVKAEDCFFVYRMVLVMFRRELTLEQTLHLWEVIWADQAAI 442

  Fly  1091 ASG------------------HFVLFLALALLETYRDIILSNSMDFTDVIKFFNEMAERHNAQSV 1137
            .:|                  ..:|::..|.:...|.:|:.......::::..:.|..:.:...:
plant   443 RAGMGKSSWSRRIKQRAPPTEDLLLYVVAASVLQRRKVIIEKYSSMEEILRECHNMVGKLDVWKL 507

  Fly  1138 LQLARSLVLQLQMIIEN 1154
            |..|..|::.|...||:
plant   508 LDDAHDLIVTLHAKIEH 524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tbc	NP_001285494.1	RUN	45..218	CDD:280855
		PH_RUTBC	292..466	CDD:275431
		TBC	923..1087	CDD:214540	43/169 (25%)
AT5G24390	NP_197827.1	TBC	<322..482	CDD:214540	41/162 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810