DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tbc and AT2G43490

DIOPT Version :9

Sequence 1:	NP_001285494.1	Gene:	tbc / 318059	FlyBaseID:	FBgn0052506	Length:	1155	Species:	Drosophila melanogaster
Sequence 2:	NP_001118514.1	Gene:	AT2G43490 / 818950	AraportID:	AT2G43490	Length:	745	Species:	Arabidopsis thaliana

Alignment Length:	523	Identity:	125/523 - (23%)
Similarity:	212/523 - (40%)	Gaps:	87/523 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   589 LTKERWQL-LNVNGVLENATEFYRLVYFGGVQPELRQEVWPYLLGHYAFGSTTEDRKKQDETCKH 652
            |..|:||. .:.:|.:....:..:|:..||:.|.:|.|||.:|||.||..||:|.|.:.....:.
plant    50 LKPEKWQASFDSDGRVSGFQKALKLIILGGIDPSIRAEVWEFLLGCYALSSTSEYRNQLRVARRK 114

  Fly   653 YYETTMSEWLAVDAIVQQREKEKTARAV-AKLSSGSNSGNDRTVRAADLEAGGDLEN--EVFEDI 714
            .|...:.:...:.:.|   .....|..| :|:.....|..|..|:.|..:     ||  :.|.|.
plant   115 RYNDLLKQCQTMHSSV---GTGSLAYVVGSKVMDMRKSYRDEAVKVATTD-----ENREDAFIDN 171

  Fly   715 SDISDPGDLEFDEQQQQQQQQAECAVSGNHLTVKPIPRAMKTSTDSGHVDESFNELDEPDEEDNK 779
            :|                                      ..:|::.|.|.|.|..|
plant   172 ND--------------------------------------NANTENHHSDWSNNGTD-------- 190

  Fly   780 QKQQQDEKISESES-KLPDYRKLEEQINQEPSCSASTASSYETVGPGEVHQRPNSDTRSVLSPEY 843
             ......:.|.||| .|...|:..|.:....|...|.:|.|....|......|:.....:.....
plant   191 -TSHLHRRGSSSESVDLVSGRESPESVVYNTSSFVSASSPYGYASPDGYFDFPSLPVTDLFGRNS 254

  Fly   844 LSADDLQLPDDEDAVRP---PPPPAAAAVIITKASVDITNWERSP---KAAEGDQMSPLEEQAGE 902
            |...::..||::.:::.   ..........|.|.:..|....||.   |....|.:.|
plant   255 LDKIEVSTPDEDASLKSELRSEDEGMHNFRIDKNADLIREQRRSTPEIKVMHSDSVGP------- 312

  Fly   903 SGGAGVN---MDALQ---QPKSACASPASSNGGVYSSELLEQFGLNLHRIEKDVQRCDRNYWYFA 961
            |...|.|   :|.|:   .|:.|......|..|..:.:.:.::...||||..||.|.|.:..::.
plant   313 SSYTGRNAEIVDGLRISDVPEMASVKDTPSRVGNVTEDRVSEWLWTLHRIVVDVVRTDSHLEFYE 377

  Fly   962 NE-NLDKLRNVISTYVWEHLDVGYMQGMCDLVAPLLVIFDDESLSYSCFCKLMERMIENF----P 1021
            :. ||.::.::::.|.|.....||.|||.|||:|.:|:|:|.:.::.||..|:.|...||    |
plant   378 DPGNLGRMSDILAVYAWVDPATGYCQGMSDLVSPFVVLFEDNADAFWCFEMLIRRTRANFQMEGP 442

  Fly  1022 SGGAMDMHFANMRSLIQILDSEMYDLMDSNGDYTHFYFCYRWFLLDFKRELVYDDVFATWEVIWA 1086
            : |.|| ...::..::||.|.:::..:...|..: .:|.:|..|:.|:|||.:::....||::||
plant   443 T-GVMD-QLQSLWHILQITDKDIFSHLSRIGAES-LHFAFRMLLVLFRRELSFNEALRMWEMMWA 504

  Fly  1087 AKH 1089
            |.:
plant   505 ADY 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tbc	NP_001285494.1	RUN	45..218	CDD:280855
		PH_RUTBC	292..466	CDD:275431
		TBC	923..1087	CDD:214540	50/168 (30%)
AT2G43490	NP_001118514.1	TBC	<358..508	CDD:214540	50/153 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810