Protein Alignment tbc and sgsm2

DIOPT Version :9

• Sequence 1: NP_001285494.1
• Gene: tbc / 318059
• FlyBaseID: FBgn0052506
• Length: 1155
• Species: Drosophila melanogaster
• Sequence 2: XP_003200084.2
• Gene: sgsm2 / 799094
• ZFINID: ZDB-GENE-131119-52
• Length: 1056
• Species: Danio rerio
• Alignment Length: 1228
• Identity: 523/1228 - (42%)
• Similarity: 684/1228 - (55%)
• Gaps: 249/1228 - (20%)

  Fly     4 GNADGSDYKERLIASVKKEVKQLMEEAVTKKYVHEESSSVTSLCGAVEACLSQGLRRRALGLFKT 68
            |:....::||:|:.:||:||||:||||||||:|||:||.:.:||.::|||||..|:|||.|..::
Zfish     2 GSTTDEEFKEKLLWNVKREVKQIMEEAVTKKFVHEDSSHIIALCSSIEACLSHLLKRRAAGFLRS 66

  Fly    69 SSTTALLHKIAKSCPEAEHISKLVQEIEASDPSKRSSSSSDSFQRPPMLKKSSSNSMSTGTNAAA 133
            ....||..||.|.......|.:.|||              ...|:..:.:::.|....:.....:
Zfish    67 DKIAALFTKIGKVNTTVSEICRKVQE--------------QLQQQAEITRRTQSTGQESLRRQGS 117

  Fly   134 STSSASASISVSASTSSMSLASMKYLWIRLALYEKRLTKIIEYLVSNASSFYDRDSLVADSDYGS 198
            ||..|...:|..|         :|::|:|.||:||.|.||::|:|.|||.:|:|::|:.||.:|.
Zfish   118 STGRAPQPLSAQA---------IKHIWVRTALFEKVLDKIVQYIVDNASKYYEREALMHDSVFGP 173

  Fly   199 ILSSLLVGPCALEFTRAKTADHYWTDPHADELVQRHRISSCRRSS--STCSRPAIINFKRSLNTS 261
            ||::|||||||||:|:.||:||:||||.|:||||||||....|..  |...|||:...||.
Zfish   174 ILAALLVGPCALEYTKLKTSDHFWTDPSANELVQRHRIHGAHRGQEVSPGRRPALGIRKRQ---- 234

  Fly   262 SDEAGTGSFKSIASASVAKDYVESLHQNAKATLLYGKNNVQVLPKDVAEPMPGYLSLHQHIQTLT 326
                .:||......|:.|::||||||||::..||||||||.|.||...|.:.|||||||..:|||
Zfish   235 ----SSGSMSEDKFAASAREYVESLHQNSRVHLLYGKNNVLVQPKKDMEVLRGYLSLHQTAETLT 295

  Fly   327 IKWTPNQLMNGYTEAEEAEDIDKDAFWAYALNINVDEIVYVHCHQSRGEDSGGTVILVGQDGVQR 391
            :|||||||:|| |..:  .|::|..:|.|||.:.:.:||.:||||.  .|.|||::||.|||:||
Zfish   296 LKWTPNQLING-TLGD--CDLEKSIYWDYALTVPLRQIVCIHCHQR--PDCGGTLVLVSQDGIQR 355

  Fly   392 PPIHFPEGGHMQQFLSCLETGLLPHGQLDPPLWSQRGIGKMF--LWPRSMRRRILPSVMESVDET 454
            ||:|||.|||:..|||||||||||.|||:||||||||.||:|  |..|:...|::....:..|:.
Zfish   356 PPLHFPPGGHLLAFLSCLETGLLPRGQLEPPLWSQRGKGKVFPKLRKRNSTARLVDQDGDGEDQI 420

  Fly   455 PIDYVFRIVSKS-RH----------------------EEFAATHSILDFVRS------------- 483
            ..|||||||... ||                      ||....|:::..:.|
Zfish   421 AADYVFRIVYPGHRHDSITINYHHSTGSRAPSLDDDEEEEDRLHAMISMICSRNLTDPNVMKDHG 485

  Fly   484 --------------------TPRRAQLSSCSTTGSSDCSNKSLSI--------DQFPMESPLILQ 520
                                |...:...||||.|    ||.|:.:        |:.|
Zfish   486 DLMEMQGFGGSPLSWQQGECTSHMSSCLSCSTGG----SNASVELPASCTCMHDRIP-------- 538

  Fly   521 QQQQQQQQLLQAQSTSIEMVCSTMRRQIISRAFYGWLAYCRHLSTVRTHLSGLVHGRITPEMKAD 585
                            ::|:|..|:|||:||||||||||||||||||||||.||:..|.|..|..
Zfish   539 ----------------LKMLCQNMKRQIVSRAFYGWLAYCRHLSTVRTHLSALVNHNIVPPDKPC 587

  Fly   586 EE--GLTKERWQLLNVNGVLENATEFYRLVYFGGVQPELRQEVWPYLLGHYAFGSTTEDRKKQDE 648
            |.  ||:|:.|.....:.......|..||||:|||:.|:|:||||:|||||.||...::..:.||
Zfish   588 EASGGLSKDVWSKYQKDCKNYKELELLRLVYYGGVEHEIRKEVWPFLLGHYKFGMDKKNMAQIDE 652

  Fly   649 TCKHYYETTMSEWLAVDAIVQQREKEKTARAVAKLSSGSNSGNDRTVRAADLEAGGDLENEVFED 713
            .....|:..|.||.|.:.||:|||||..:...||||||| |.:...:|.  :.....:.||||..
Zfish   653 KITARYQQVMREWKACEVIVKQREKEMQSAIFAKLSSGS-SIDSHVLRL--IHRDSTISNEVFMS 714

  Fly   714 ISDISDPGDLEFDEQQQQQQQQAECAVSGNHLTVKPIPRAMKTSTDSGHVDESFNELDEPDEEDN 778
            : |..|.|.           |...|..|...||....|..:...      :....|.|.||
Zfish   715 V-DEPDAGG-----------QDTSCEDSTPTLTTVVTPAMLAPD------ERPLVEFDSPD---- 757

  Fly   779 KQKQQQDEKISESESKLPDYRKLEEQINQEPSCSASTASSYETVGPGEVHQRPNSDTRSVLSPEY 843
                          |.||..|            :.|.||.:.                .::|
Zfish   758 --------------SGLPSSR------------NYSVASGHS----------------QIMS--- 777

  Fly   844 LSADDLQLPDDEDAVRPPPPPAAAAVIITKASVDITNWERSPKAAEGDQMSPLEEQAGESGGAG- 907
             |.||.|..::                           :.:|...       ||||    ||.|
Zfish   778 -SIDDGQSMEE---------------------------DTTPTGG-------LEEQ----GGRGS 803

  Fly   908 VNMDALQQPKSACASPASSNG-----GVYSSELLEQFGLNLHRIEKDVQRCDRNYWYFANENLDK 967
            ::.|.|........:.:||.|     ..|:.|||:...||||||:||||||||||:||.:.||:|
Zfish   804 LSEDKLCSQLDKLTTTSSSEGTAPSFSSYTIELLDTVALNLHRIDKDVQRCDRNYYYFTSSNLEK 868

  Fly   968 LRNVISTYVWEHLDVGYMQGMCDLVAPLLVIFDDESLSYSCFCKLMERMIENFPSGGAMDMHFAN 1032
            |||::.:||||||::||:||||||:|||:||.|||.|:||||.:||.||.:|||:|||||.||||
Zfish   869 LRNIMCSYVWEHLEIGYVQGMCDLLAPLMVILDDECLAYSCFTQLMRRMSQNFPTGGAMDTHFAN 933

  Fly  1033 MRSLIQILDSEMYDLMDSNGDYTHFYFCYRWFLLDFKRELVYDDVFATWEVIWAAKHIASGHFVL 1097
            |||||||||||:::||..||||||||||||||||||||||:|:||||.|||||.|..|:|.||||
Zfish   934 MRSLIQILDSELFELMHQNGDYTHFYFCYRWFLLDFKRELLYEDVFAVWEVIWVAPRISSKHFVL 998

  Fly  1098 FLALALLETYRDIILSNSMDFTDVIKFFNEMAERHNAQSVLQLARSLVLQLQMIIENK 1155
            |:||||:|.||||||.|:|||||:|||||||||||:.|.:|::||.||.::|.:||||
Zfish   999 FIALALVEVYRDIILDNNMDFTDIIKFFNEMAERHDVQHILRMARELVHKVQTLIENK 1056

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tbc	NP_001285494.1	RUN	45..218	CDD:280855	62/172 (36%)
		PH_RUTBC	292..466	CDD:275431	99/175 (57%)
		TBC	923..1087	CDD:214540	119/168 (71%)
sgsm2	XP_003200084.2	RUN	43..189	CDD:308412	60/168 (36%)
		PH_RUTBC	262..432	CDD:275431	99/174 (57%)
		TBC	<844..1013	CDD:214540	127/168 (76%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	294	1.000	Domainoid score	I1468
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	942	1.000	Inparanoid score	I333
OMA	1	1.010	-	-		QHG48923
OrthoDB	1	1.010	-	-		D171826at2759
OrthoFinder	1	1.000	-	-		FOG0002045
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_103962
Panther	1	1.100	-	-	O	PTHR22957
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1347
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.840