DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tbc and GRTP1

DIOPT Version :9

Sequence 1:	NP_001285494.1	Gene:	tbc / 318059	FlyBaseID:	FBgn0052506	Length:	1155	Species:	Drosophila melanogaster
Sequence 2:	NP_001273661.1	Gene:	GRTP1 / 79774	HGNCID:	20310	Length:	344	Species:	Homo sapiens

Alignment Length:	271	Identity:	66/271 - (24%)
Similarity:	109/271 - (40%)	Gaps:	44/271 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   895 PLEEQAG---ESGGAGVNMDALQQPKSACASPASSNGGVYSSELLEQFGLNLHRIEKDVQRCDRN 956
            |||.:|.   ...||...||              .|.|.| .:||:  |....|:| |..|.|.|
Human    70 PLEHRARVWMVLSGAQAQMD--------------QNPGYY-HQLLQ--GERNPRLE-DAIRTDLN 116

  Fly   957 YWYFANENLDK---------LRNVISTYVWEHLDVGYMQGMCDLVAPLLVIFDDESLSYSCFCKL 1012
            ..:..|....|         |.||:..|...:..|||.|||..:...|::|.::|..|:.....|
Human   117 RTFPDNVKFRKTTDPCLQRTLYNVLLAYGHHNQGVGYCQGMNFIAGYLILITNNEEESFWLLDAL 181

  Fly  1013 MERMIENFPSGGAMDMHFAN--MRSLIQILDSEMYDLMDSNGDYTHFYFCYRWFLLDFKRELVYD 1075
            :.|::.::.|...:.:....  :..|::.....:..||:..| ........|||:..|...|..:
Human   182 VGRILPDYYSPAMLGLKTDQEVLGELVRAKLPAVGALMERLG-VLWTLLVSRWFICLFVDILPVE 245

  Fly  1076 DVFATWEVIWAAKHIASGHFVLF-LALALLETYRDIIL--SNSMDFTDVIKFFNE---MAERHNA 1134
            .|...|:.::     ..|..::| :||.|::.::::||  ::..|..|..|...:   :.|.|..
Human   246 TVLRIWDCLF-----NEGSKIIFRVALTLIKQHQELILEATSVPDICDKFKQITKGSFVMECHTF 305

  Fly  1135 QSVLQLARSLV 1145
            ..|...||..|
Human   306 MQVCGAARGSV 316

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tbc	NP_001285494.1	RUN	45..218	CDD:280855
		PH_RUTBC	292..466	CDD:275431
		TBC	923..1087	CDD:214540	42/174 (24%)
GRTP1	NP_001273661.1	TBC	65..278	CDD:214540	55/231 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900