Protein Alignment tbc and GRTP1

DIOPT Version :10

• Sequence 1: NP_608395.6
• Gene: tbc / 318059
• FlyBaseID: FBgn0052506
• Length: 1155
• Species: Drosophila melanogaster
• Sequence 2: NP_001273661.1
• Gene: GRTP1 / 79774
• HGNCID: 20310
• Length: 344
• Species: Homo sapiens
• Alignment Length: 271
• Identity: 66/271 - (24%)
• Similarity: 109/271 - (40%)
• Gaps: 44/271 - (16%)

  Fly   895 PLEEQAG---ESGGAGVNMDALQQPKSACASPASSNGGVYSSELLEQFGLNLHRIEKDVQRCDRN 956
            |||.:|.   ...||...||              .|.|.| .:||:  |....|:| |..|.|.|
Human    70 PLEHRARVWMVLSGAQAQMD--------------QNPGYY-HQLLQ--GERNPRLE-DAIRTDLN 116

  Fly   957 YWYFANENLDK---------LRNVISTYVWEHLDVGYMQGMCDLVAPLLVIFDDESLSYSCFCKL 1012
            ..:..|....|         |.||:..|...:..|||.|||..:...|::|.::|..|:.....|
Human   117 RTFPDNVKFRKTTDPCLQRTLYNVLLAYGHHNQGVGYCQGMNFIAGYLILITNNEEESFWLLDAL 181

  Fly  1013 MERMIENFPSGGAMDMHFAN--MRSLIQILDSEMYDLMDSNGDYTHFYFCYRWFLLDFKRELVYD 1075
            :.|::.::.|...:.:....  :..|::.....:..||:..| ........|||:..|...|..:
Human   182 VGRILPDYYSPAMLGLKTDQEVLGELVRAKLPAVGALMERLG-VLWTLLVSRWFICLFVDILPVE 245

  Fly  1076 DVFATWEVIWAAKHIASGHFVLF-LALALLETYRDIIL--SNSMDFTDVIKFFNE---MAERHNA 1134
            .|...|:.::     ..|..::| :||.|::.::::||  ::..|..|..|...:   :.|.|..
Human   246 TVLRIWDCLF-----NEGSKIIFRVALTLIKQHQELILEATSVPDICDKFKQITKGSFVMECHTF 305

  Fly  1135 QSVLQLARSLV 1145
            ..|...||..|
Human   306 MQVCGAARGSV 316

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tbc	NP_608395.6	RUN_SGSM1_like	21..214	CDD:439049
		PH_RUTBC	292..466	CDD:275431
		TBC	923..1087	CDD:214540	42/174 (24%)
GRTP1	NP_001273661.1	TBC	65..278	CDD:214540	55/231 (24%)