Protein Alignment tbc and TBC1D17

DIOPT Version :10

• Sequence 1: NP_608395.6
• Gene: tbc / 318059
• FlyBaseID: FBgn0052506
• Length: 1155
• Species: Drosophila melanogaster
• Sequence 2: NP_078958.2
• Gene: TBC1D17 / 79735
• HGNCID: 25699
• Length: 648
• Species: Homo sapiens
• Alignment Length: 610
• Identity: 147/610 - (24%)
• Similarity: 231/610 - (37%)
• Gaps: 166/610 - (27%)

  Fly   630 LLGHYA----FGSTTEDR-KKQD----ETCKHYYETTMS-----EWLAVDAIVQQR-EKEKTARA 679
            :|.|:|    .|.:|:.. .|:|    ::|....|.|..     :|..:..:..|. ..|.|..|
Human    44 VLLHWAPVEEAGDSTQILFSKKDSSGGDSCASEEEPTFDPGYEPDWAVISTVRPQLCHSEPTRGA 108

  Fly   680 VAKLSSGS-----NSGNDRTVRAAD-----------LEAGGDLENEVFEDISDISDPGDLEFDEQ 728
            ......||     :.|..:::|.:.           .:|||.|             |. |.|
Human   109 EPSCPQGSWAFSVSLGELKSIRRSKPGLSWAYLVLVTQAGGSL-------------PA-LHF--- 156

  Fly   729 QQQQQQQAECAVSGNHLTVKPIPRAMKT----STDSGHVDESFNELDEPDEEDNKQKQQQDEKIS 789
             .:...:|...|...:|.:...|:..:.    ..||..:..||:.|...|:
Human   157 -HRGGTRALLRVLSRYLLLASSPQDSRLYLVFPHDSSALSNSFHHLQLFDQ-------------- 206

  Fly   790 ESESKLPDYRKLEEQINQEPSCSASTASSYETVGPGEVHQRPNSDTRSVLSPEYLSADDLQLPDD 854
                   |...:..:..|:|  .::|.||:         .|..:..|..|.|:         |:.
Human   207 -------DSSNVVSRFLQDP--YSTTFSSF---------SRVTNFFRGALQPQ---------PEG 244

  Fly   855 EDAVRPPPP---PAAAAVIITKASVDI---TNWERSPKAAEGDQMSPLEEQAGESGGAGVNMDAL 913
            ..:..||||   |.....:|  :.|::   ...||.|...|       ||.|...|..|    .|
Human   245 AASDLPPPPDDEPEPGFEVI--SCVELGPRPTVERGPPVTE-------EEWARHVGPEG----RL 296

  Fly   914 QQ-PK------SACASP-------------------ASSNGGVYSSELLEQFGLNLH-------- 944
            || |:      |...||                   |..:......:..|.|.:.|.
Human   297 QQVPELKNRIFSGGLSPSLRREAWKFLLGYLSWEGTAEEHKAHIRKKTDEYFRMKLQWKSVSPEQ 361

  Fly   945 ------------RIEKDVQRCDR-NYWYFANEN--LDKLRNVISTYVWEHLDVGYMQGMCDLVAP 994
                        .||:||.|.|| |.:|...||  |..|.:::.||...|.|:||:|||.||::|
Human   362 ERRNSLLHGYRSLIERDVSRTDRTNKFYEGPENPGLGLLNDILLTYCMYHFDLGYVQGMSDLLSP 426

  Fly   995 LLVIFDDESLSYSCFCKLMERMIENF-PSGGAMDMHFANMRSLIQILDSEMYDLMDSNGDYTHFY 1058
            :|.:..:|..::.|||..||.:..|| .|...|......:..|:::||..:.|.:||. |.....
Human   427 ILYVIQNEVDAFWCFCGFMELVQGNFEESQETMKRQLGRLLLLLRVLDPLLCDFLDSQ-DSGSLC 490

  Fly  1059 FCYRWFLLDFKRELVYDDVFATWEVIWAAKHIASGHFVLFLALALLETYRDIILSNSMDFTDVIK 1123
            ||:||.|:.||||..:.||...|||:|..  :...:..|.:|.|:|:..||.::.:.....:::|
Human   491 FCFRWLLIWFKREFPFPDVLRLWEVLWTG--LPGPNLHLLVACAILDMERDTLMLSGFGSNEILK 553

  Fly  1124 FFNEMAERHNAQSVLQLARSLVLQL 1148
            ..||:..:.:.:.||..|.:|..||
Human   554 HINELTMKLSVEDVLTRAEALHRQL 578

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tbc	NP_608395.6	RUN_SGSM1_like	21..214	CDD:439049
		PH_RUTBC	292..466	CDD:275431
		TBC	923..1087	CDD:214540	63/206 (31%)
TBC1D17	NP_078958.2	PH_RBD	7..205	CDD:432305	35/178 (20%)
		Required for interaction with OPTN. /evidence=ECO:0000269|PubMed:22854040	218..309		29/123 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	240..259		7/27 (26%)
		TBC	307..542	CDD:214540	71/237 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	594..648