DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment tbc and si:dkey-238d18.4

DIOPT Version :10

Sequence 1:NP_608395.6 Gene:tbc / 318059 FlyBaseID:FBgn0052506 Length:1155 Species:Drosophila melanogaster
Sequence 2:XP_003200122.1 Gene:si:dkey-238d18.4 / 796120 ZFINID:ZDB-GENE-131121-307 Length:472 Species:Danio rerio


Alignment Length:626 Identity:126/626 - (20%)
Similarity:200/626 - (31%) Gaps:271/626 - (43%)


- Green bases have known domain annotations that are detailed below.


  Fly   560 CRHLSTVRTHLSGLVHGRITPEMKADEEGLTKERWQLLNVNGVLENATEFYRLVYFGGVQPELRQ 624
            ||.::.|.:..|  ...|||.....|.||...|  ..|..: :.:|          |||.|:.|.
Zfish    43 CRSVAPVISPAS--TCARITLPGVMDAEGRVDE--SRLRTH-IFKN----------GGVSPDERG 92

  Fly   625 EVWPYLLGHYAFGSTTEDRKKQDETCKHYYETTMSEWLAVDAIVQQREKEKTARAVAKLSSGSNS 689
            :||.:|...|...||..:|            ..:.|.:||...|.:|:.::......:|..   :
Zfish    93 QVWRFLFSMYPCSSTALER------------PLLLEQMAVRYQVMKRKWQQLLPGAVRLRL---N 142

  Fly   690 GNDRTVRAADLEAGGDLENEVFEDISDISDPGDLEFDEQQQQQQQQAECAVSGNHLTVKPIPRAM 754
            |.|..:..|                        ::|.:|:|                        
Zfish   143 GTDAELLTA------------------------VKFFDQRQ------------------------ 159

  Fly   755 KTSTDSGHVDESFNELDEPDEEDNKQKQQQDEKISESESKLPDYRKLEEQINQEPSCSASTASSY 819
                               |.|.|||:.|.||                                 
Zfish   160 -------------------DRELNKQQIQSDE--------------------------------- 172

  Fly   820 ETVGPGEVHQRPNSDTRSVLSPEYLSADDLQLPDDEDAVRPPPPPAAAAVIITKASVDITNWERS 884
                                :.|.||...||                |.|:..:.:.|       
Zfish   173 --------------------TQERLSFLQLQ----------------AQVLFERVTFD------- 194

  Fly   885 PKAAEGDQMSPLEEQAGESGGAGVNMDALQQPKSACASPASSNGGVYSSELLEQFGLNLHRIEKD 949
                       |||              ||:.                          :..|:||
Zfish   195 -----------LEE--------------LQEA--------------------------IRIIDKD 208

  Fly   950 VQRCDRNYWYFANE---NLDKLRNVISTYVWEHLDVGYMQGMCDLVAPLLVIFDDESLSYSCFCK 1011
            |.|.||:..|:.||   ||..||:::.||...|.:|.|.|||.||.:..|.:.|.|..:|..|..
Zfish   209 VPRTDRDLPYYRNEGLGNLLVLRDILITYAAFHPEVSYAQGMNDLCSRFLEVLDSEVDTYWSFSC 273

  Fly  1012 LMERMIENFPSGG---AMDMHFANMRSLIQILDSEMYD-LMDSNGDYTHFYFCYRWFLLDFKREL 1072
            .||:..::|.:.|   .|::..|    |::.||.:::. |:..|.:  ...||:||.||.|:||.
Zfish   274 YMEKFSKDFRADGLYRKMELEAA----LLKELDPQLHSHLVTDNME--RLTFCHRWLLLGFQREF 332

  Fly  1073 VYDDVFATWEVI--------------------WAAKH------IASGH-------FVLFLALALL 1104
            .:.|....:|::                    .|.||      :|..|       |.||:...:|
Zfish   333 EHSDALRLFEILSCDHLELISQQVDCVRYQERLARKHSLEEEPVADLHAVNTDFTFELFMCATIL 397

  Fly  1105 ETYRDIILSNSMDFTDVIKFFNEMAERHNAQSVLQLARSLV 1145
            ...|:.:||...: ..:|:|.:.:..:.:..:.|:.|..|:
Zfish   398 LENREALLSCKNE-VQLIQFTSSLQGKLDLNATLKKAEELM 437

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
tbcNP_608395.6 RUN_SGSM1_like 21..214 CDD:439049
PH_RUTBC 292..466 CDD:275431
TBC 923..1087 CDD:214540 51/190 (27%)
si:dkey-238d18.4XP_003200122.1 TBC <204..352 CDD:214540 51/153 (33%)
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.