DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tbc and Tbc1d9b

DIOPT Version :9

Sequence 1:	NP_001285494.1	Gene:	tbc / 318059	FlyBaseID:	FBgn0052506	Length:	1155	Species:	Drosophila melanogaster
Sequence 2:	NP_001277689.1	Gene:	Tbc1d9b / 76795	MGIID:	1924045	Length:	1263	Species:	Mus musculus

Alignment Length:	751	Identity:	152/751 - (20%)
Similarity:	262/751 - (34%)	Gaps:	265/751 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   518 ILQQQQQQQQQLLQAQSTSIEMVCSTMRRQIISRAFYGWLA--YCRHLS------TVRTHLSGLV 574
            ||.|.|..|...:.|        |.:.|::|...  :.||.  ..:.||      .:.|.:.|.:
Mouse    61 ILHQTQDSQVYWIVA--------CGSSRKEITKH--WEWLENNLLQTLSIFDNEEDITTFVKGKI 115

  Fly   575 HGRITPEMK-----ADEE-GLTKE-----RWQLLNVNGVLENATEFYRLVYFGGVQPELRQEVWP 628
            ||.|..|.|     .||: |..||     |.|.....|  |....:|...::.|..|   ::.|.
Mouse   116 HGIIAEENKNLQPQGDEDPGKFKEAELKMRKQFGMPEG--EKLVNYYSCNFWKGRVP---RQGWL 175

  Fly   629 YL-LGHYAFGSTTEDRKKQDETCKHYYETTMSEWLAVDAIVQQREKEKTARAVAKLSSGSNSGND 692
            || :.|..|.|....::          .:.:.:|:.|..:      ||.|..:.          .
Mouse   176 YLTVNHLCFYSFLLGKE----------VSLVVQWVDVTRL------EKNATLLF----------P 214

  Fly   693 RTVRAADLEAGGDLENEVFEDISDISDPGDLEFDEQQQQQQQQAECAV-----SGNHLTVKPIPR 752
            .::|.      ...:.|:|..:.       |...|..:..:|.|..|:     |...|..|.:||
Mouse   215 ESIRV------DTRDQELFFSMF-------LNIGETFKLMEQLANLAMRQLLDSEGFLEDKALPR 266

  Fly   753 ---------AMKTSTDS--------------------GHVD----ESFNELDEPDE---EDNK-- 779
                     |:|...|:                    ||..    ..||:|..|.:   .:|.
Mouse   267 PIRPHKNISALKRDLDARAKNECYRATFRLPKDERLDGHTGCTLWTPFNKLHIPGQMFISNNYIC 331

  Fly   780 -QKQQQD--------------EKISESESKLP---------------------DY--RKLEEQIN 806
             ..:::|              || ::|.|.||                     |:  :::.:.:.
Mouse   332 FASKEEDACRLIIPLREVTIVEK-ADSSSVLPSPLSISTKSKMTFLFANLKDRDFLVQRISDFLQ 395

  Fly   807 QEPSCSASTASSYETVGPGEVHQRPNSDTRSVLS---PEYLSADDLQLPDDEDAVRPPPPPAAAA 868
            :.|  |..|.||   :|          .|::.:|   ||       .||..::|..||..|::..
Mouse   396 KTP--SKQTGSS---IG----------GTKASVSDPAPE-------SLPTPQEASEPPASPSSPL 438

  Fly   869 VIITKASVDITNWERSPKAAEG-----DQMSPLEEQAGESGG------AGVNMDALQQPKSAC-- 920
                 :|....:.:..|..::|     .:.||:|: .|..|.      ...|:...:..:..|
Mouse   439 -----SSPPSFSTQEIPTTSQGLLKVFQKNSPMED-LGAKGAKEKMKEESWNIHFFEYGRGMCMY 497

  Fly   921 -----------ASPASSNGGV----------------YSSELLE----QFGLNLHRIEKDVQRCD 954
                       ..|.|..|.:                |.:||:|    ::.|....||:|:.|..
Mouse   498 RTAKTRELVLKGIPESLRGELWLLFSGAWNEMVTHPGYYAELVEKSLGKYSLATEEIERDLHRSM 562

  Fly   955 RNYWYFANE-NLDKLRNVISTYVWEHLDVGYMQGMCDLVAPLLVIFDDESLSYSCFCKLMERMIE 1018
            ..:..|.|| .:..||.|::.|.:.:..:||.|.| ::|..:|:::..|..::.....|.|||:.
Mouse   563 PEHPAFQNELGIAALRRVLTAYAFRNPTIGYCQAM-NIVTSVLLLYGSEEEAFWLLVALCERMLP 626

  Fly  1019 NFPS----GGAMDMH-FANM-RSLIQILDSEMYDL--MDSNGDYTHFYFCYRWFL------LDFK 1069
            ::.:    |..:|.. |..: |.::..|..:|.:|  :.|        ....|||      :.|:
Mouse   627 DYYNTRVVGALVDQGIFEELTRDVLPRLSEKMQELGVISS--------ISLSWFLTLFLSVMPFE 683

  Fly  1070 RELVYDDVFATWEVIWAAKHIASGHFVLFLALALLE 1105
            ..:|..|.| .:|.|         ..:|.:|||:|:
Mouse   684 SAVVIVDCF-FYEGI---------KVILQVALAVLD 709

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tbc	NP_001285494.1	RUN	45..218	CDD:280855
		PH_RUTBC	292..466	CDD:275431
		TBC	923..1087	CDD:214540	47/198 (24%)
Tbc1d9b	NP_001277689.1	PH-GRAM1_TCB1D9_TCB1D9B	153..251	CDD:275420	24/141 (17%)
		PH-GRAM2_TCB1D9_TCB1D9B	299..394	CDD:270161	15/95 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	397..449		17/78 (22%)
		TBC	506..716	CDD:214540	52/223 (23%)
		EFh	<856..907	CDD:298682
		EFh	887..912	CDD:197492
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	977..1002
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1075..1126
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1139..1159
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900