DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tbc and Tbc1d30

DIOPT Version :9

Sequence 1:	NP_001285494.1	Gene:	tbc / 318059	FlyBaseID:	FBgn0052506	Length:	1155	Species:	Drosophila melanogaster
Sequence 2:	XP_030101194.1	Gene:	Tbc1d30 / 74694	MGIID:	1921944	Length:	909	Species:	Mus musculus

Alignment Length:	958	Identity:	167/958 - (17%)
Similarity:	291/958 - (30%)	Gaps:	315/958 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 VKKEVKQLMEEAVTKKYVHEESSS--------VTSLCGAVEACLSQGLRRRALGLFKTSSTTALL 75
            |.:|:::.....:..:|:..:.||        :....|...|.|.:.|:::          ..||
Mouse   100 VLQELRERPSLRLQMQYLQRKDSSELKTVLRELKYRIGIQSAKLLRQLKQK----------DRLL 154

  Fly    76 HKIAKSCPEAEHISKLVQEIEASDPSKRSSSSSDSFQRPPMLKKSSSNSMSTGTNAAASTSSASA 140
            ||:.|:|   :.::..:|.:.    .||...:...|...|.|.::..........|.|..|
Mouse   155 HKVQKNC---DIVTACLQAVS----QKRRVDTKLKFTLEPSLGQNGFQQWYDALKAVARLS---- 208

  Fly   141 SISVSASTSSMSLASMKYLWIRLALYEKRLTKI-IEYLVSNASSFYDRDSLVADSDYGSILSSLL 204
                    :.:.....:.:|:.||  :..|..| |::..:...:|.:|.:...||....|:..|
Mouse   209 --------TGIPKEWRRKVWLTLA--DHYLHSIAIDWDKTMRFTFNERSNPDDDSMGIQIVKDL- 262

  Fly   205 VGPCALEFTRAKTADHYWTDPHADELVQRHRISSCRRSSSTCSRPAIINFKRSLNTSSDEAGTGS 269
                    .|...:.:...:...|.:|.:..:.:..|.:.........|...:|.....|...|.
Mouse   263 --------HRTGCSSYCGQEAEQDRVVLKRVLLAYARWNKNVGYCQGFNILAALILEVMEGNEGD 319

  Fly   270 FKSIASASVAKDYVESLHQNAKATLLYGKNNVQVLPKDVAE-------PMPGYLSLHQHIQTLTI 327
            ...|....:.|...||          |..||::.|..|:|.       .:|   .|.||:.||
Mouse   320 ALKIMIYLIDKVLPES----------YFVNNLRALSVDMAVFRDLLRLKLP---ELSQHLDTL-- 369

  Fly   328 KWTPNQLMNGYTEAEEAEDIDKDAFWAYALNINVDEIVYVHCHQSRGEDSGGTVILVGQDGVQRP 392
                                                      .::..::|||        |.: |
Mouse   370 ------------------------------------------QRTANKESGG--------GYE-P 383

  Fly   393 PIH--FPEGGHMQQFLSCLETGLLPHGQLDPPLWSQRGIGKMFLWPRSMRRRILPSVM----ESV 451
            |:.  |.    ||.||:...|.|..|..|  .:|.     .:|.....:..|:..::.    |.:
Mouse   384 PLTNVFT----MQWFLTLFATCLPNHTVL--KIWD-----SVFFEGSEIILRVSLAIWAKLGEQI 437

  Fly   452 D--ETPIDY---VFRIVSKSRHEEFAATHSILDFVRS--------------------TPRRAQLS 491
            :  ||..::   :.|:..:...::...:|.::..|.|                    ||..|.:.
Mouse   438 ECCETADEFYGTMGRLTQEMLEQDLLQSHELMQTVYSMAPFPFPQLAELREKYTYNITPFPATIK 502

  Fly   492 SCSTTG------SSDCSNKSLSIDQF--------PMESPLILQQQQQQQQQLLQAQSTSIEMVCS 542
            ..|.:|      .||..|.....|..        |: |.|:..:.|:.|:|:.:|...      .
Mouse   503 PTSVSGRHSKARDSDDENGPDDEDAVASAVGCLGPL-SGLLAPELQKYQKQIKEATEE------Q 560

  Fly   543 TMRRQIISRAFYGWLAYCRHLSTVRTHLSGLVHGRITPE---MKADEEGLTKERWQLLNVNGVLE 604
            |:|...|:....|.:..||  |......:.::..|:|.:   :|.....:.|::.|.|:...:..
Mouse   561 TLRSNNIAELSPGAINSCR--SEYHAAFNSMMMERMTTDINALKRQYSRIKKKQQQQLHQVYIRA 623

  Fly   605 NATEFYRLVYF------------------------------------------------------ 615
            .:.|...|.::
Mouse   624 GSKEEQDLGFYLGPEEQAVDDKGPVTSILPSQANSSPVINHLLLGKKMKITNRAAKNAVIHVPGH 688

  Fly   616 --GGVQPELRQEV-------W-----------PYLLGHYAFGSTTEDRKKQDETCKHYYETTMSE 660
              |.:.|...:::       |           |....|...|.|....::|.|.||      .|.
Mouse   689 PGGKISPVPYEDIKTKLNSPWRTHIRVHKKNMPRTKSHLGCGDTVGLIEEQSEGCK------ASS 747

  Fly   661 WLAVDAIVQQREKEKTARAVAKLSSGSNSGNDRTVRAADLEAGGDLENEVFEDISDISDPGDLEF 725
            ..|.:.....|    |..|.::.|||...|...|.|..:    |.....||         ||.:.
Mouse   748 LGAAEEFPSGR----TVTAHSEGSSGDGDGGGSTPRTIE----GQSPEPVF---------GDADV 795

  Fly   726 DEQQQQ------QQQQAECAVSGNHLTVKPIPRAMKTSTDSGHVDESFNELDEPDEEDNKQKQQQ 784
            |....|      :..|.:.|.........|..|         |..|.   .|.|.|     .|..
Mouse   796 DVAAVQVKLEALELNQRDAAAETEPKVHFPCQR---------HASEL---ADAPGE-----NQTA 843

  Fly   785 DEKISESESKLPDYRKLEEQINQEPSCSASTASSYETVGPGEVHQRPN 832
            .:.:..|.||.|.:....   :.:|...::||.:....||.|  :.||
Mouse   844 IKLLPGSTSKTPIFSPFP---SVKPLRKSATARNLGLYGPTE--RTPN 886

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tbc	NP_001285494.1	RUN	45..218	CDD:280855	32/173 (18%)
		PH_RUTBC	292..466	CDD:275431	34/191 (18%)
		TBC	923..1087	CDD:214540
Tbc1d30	XP_030101194.1	TBC	208..429	CDD:214540	55/320 (17%)
Tbc1d30	XP_030101194.1	DUF4682	598..746	CDD:374060	17/153 (11%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900