DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tbc and Tbc1d21

DIOPT Version :9

Sequence 1:	NP_001285494.1	Gene:	tbc / 318059	FlyBaseID:	FBgn0052506	Length:	1155	Species:	Drosophila melanogaster
Sequence 2:	NP_083130.1	Gene:	Tbc1d21 / 74286	MGIID:	1921536	Length:	336	Species:	Mus musculus

Alignment Length:	221	Identity:	55/221 - (24%)
Similarity:	92/221 - (41%)	Gaps:	47/221 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   935 LLEQFGLNLH--------RIEKDVQRC-DRNYWYFANENLDKL---RNVISTYVWEHLDVGYMQG 987
            |||    |||        .|..|:||. |::  ...|..:||.   :.::.:||. :....|.:|
Mouse   107 LLE----NLHGNFTETRNNIAYDIQRLYDKD--PLGNVLIDKKKLEKTLLLSYVC-NTKAEYQRG 164

  Fly   988 MCDLVA--PLLVIFDDESL----------SYSCFCKLMERMIENFPSGGAMDMHFANMRSLIQIL 1040
            ..::|.  .|:|..|.|:.          .:||        :.|...|..:||    :.|||.:|
Mouse   165 FHEMVMLFQLMVEHDHETFWLFQFFLQKTEHSC--------VINIGVGKNLDM----LNSLITLL 217

  Fly  1041 DSEMYDLMDSNGDYTHFYFCYRWFLLDFKREL-VYDDVFATWEVIWAAKHIASGHFVLFLALALL 1104
            |.|..:.:...|... ....:.||.|.|:|.. .:|||:..|||:...|  ...:|.:.:|.::|
Mouse   218 DPEFAEHLKGKGSGA-VQSLFPWFCLCFQRAFKTFDDVWRLWEVLLTGK--PCRNFQVLVAYSML 279

  Fly  1105 ETYRDIILSNSMDFTDVIKFFNEMAE 1130
            :..|:..|...|....::...|.:.:
Mouse   280 QMVREQALLECMSGDAILMACNNLID 305

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tbc	NP_001285494.1	RUN	45..218	CDD:280855
		PH_RUTBC	292..466	CDD:275431
		TBC	923..1087	CDD:214540	47/176 (27%)
Tbc1d21	NP_083130.1	TBC	62..287	CDD:214540	52/201 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900