Protein Alignment tbc and TBC1D3H

DIOPT Version :10

• Sequence 1: NP_608395.6
• Gene: tbc / 318059
• FlyBaseID: FBgn0052506
• Length: 1155
• Species: Drosophila melanogaster
• Sequence 2: XP_011523474.1
• Gene: TBC1D3H / 729877
• HGNCID: 30708
• Length: 610
• Species: Homo sapiens
• Alignment Length: 703
• Identity: 137/703 - (19%)
• Similarity: 219/703 - (31%)
• Gaps: 239/703 - (33%)

  Fly   341 AEEAEDI--------------DK--DAFWAYALNINVDEIVYVH-CHQSRGEDSGGTVILVGQDG 388
            |:|.|||              ||  ..|.:|  |.|||.:..|. |.........|..
Human    12 AQEREDIIMKYEKGHRAGLPEDKGPKPFRSY--NNNVDHLGIVQSCPSWESAPQEGPC------- 67

  Fly   389 VQRPPIHFPEGGHMQQFLSCLETGLLPHGQLD--PPLW-SQRGIGKMFLWPRSMRRRILPSVMES 450
               ||...|            ..||.|..:.|  .|.| |...:|.:   ........||.:..|
Human    68 ---PPFPVP------------SPGLSPELERDRASPFWGSAPRLGPL---QAPCSSSALPGLPYS 114

  Fly   451 VDETP------IDYVFRIVSKSRH--------EEFAATHSILD-FVRSTPRRAQLSSCSTTGSSD 500
            ..|.|      ...:.|.:|:...        |::.::..::| ..:..|...:....|..
Human   115 ETELPPLTAREAKQIRREISRKSKWVDMLGDWEKYKSSRKLIDRAYKGMPMNIRGPMWSVL---- 175

  Fly   501 CSNKSLSIDQFPMESP---LILQQQQQQQQQLLQAQSTSIEMVCSTMRRQIISRAFYGW------ 556
                 |:.::..:::|   .|::::.::..:.:|.....|.   .|:|:.:..|..||.
Human   176 -----LNTEEMKLKNPGRYQIMKEKGKRSSEHIQRIDRDIS---GTLRKHMFFRDRYGTKQRELL 232

  Fly   557 ------------LAYCRHLSTVRTHLSGLVHGRITPEMKADEEGLTKERWQLLNVNGVLENATEF 609
                        :.|||.||    |::.|.. ...||..|        .|.|:.:     .|:|.
Human   233 HILLAYEEYNPEVGYCRDLS----HIAALFL-LYLPEEDA--------FWALVQL-----LASER 279

  Fly   610 YRLVYFGGVQPELRQEVWPYLLGHYAFGSTTEDRKKQDETCKHYYETTMSEWLAVDAIVQQREKE 674
            :.|..|                 |...|.|.:..:.|.|   |...|:..:.:.     .|.:|:
Human   280 HSLQGF-----------------HSPNGGTVQGLQDQQE---HVVATSQPKTMG-----HQDKKD 319

  Fly   675 KTARA------VAKLSSGSNSGNDRTVRAADLEAGGDLENEVFEDISDISDPGDLEFDEQQQQQQ 733
            ...:.      :..|..|.:.|  .|:|..|:..   :|.|  :.:..|:   .:.|..||::..
Human   320 LCGQCSPLGCLIRILIDGISLG--LTLRLWDVYL---VEGE--QALMPIT---RIAFKVQQKRLT 374

  Fly   734 QQAECAVSGNHLTVKPIPRAMKTSTDSGHVDESFNELDEPDEEDNKQKQQQDEKISESESKLPDY 798
            :.:.|.         |..|......|:...||         :...|..:...:|::..:..||..
Human   375 KTSRCG---------PWARFCNRFVDTWARDE---------DTVLKHLRASMKKLTRKQGDLPPP 421

  Fly   799 RKLEEQINQEPSCSASTASSYETVGPGEVHQRPNSDTRSVLSPEYLSADDLQLPDDEDAVRPPPP 863
            .|.|:         .|:||            ||...:|   ..:.|...|.|        .||.|
Human   422 AKPEQ---------GSSAS------------RPVPASR---GGKTLCKGDRQ--------APPGP 454

  Fly   864 PAAAAVIITKASVDITNWERSPKAAEGDQMSPLEEQAGESGGAGVNMDALQQPKSACASPASSNG 928
            ||.....|..||        .|:|.......|        ||| |..|..........|||.:.|
Human   455 PARFPRPIWSAS--------PPRAPRSSTPCP--------GGA-VREDTYPVGTQGVPSPALAQG 502

  Fly   929 GVYSSELLEQFGLNLHRIEKDV-------------QRCDRNYWYFANENLDKL 968
            |...|....|:. ::.|:..|:             |.|    |..|....|:|
Human   503 GPQGSWRFLQWN-SMPRLPTDLDVEGPWFRHYDFRQSC----WVRAISQEDQL 550

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tbc	NP_608395.6	RUN_SGSM1_like	21..214	CDD:439049
		PH_RUTBC	292..466	CDD:275431	34/150 (23%)
		TBC	923..1087	CDD:214540	14/59 (24%)
TBC1D3H	XP_011523474.1	TBC	160..373	CDD:214540	49/277 (18%)
		PHA03381	<417..>529	CDD:177618	38/161 (24%)