DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tbc and TBC1D3H

DIOPT Version :9

Sequence 1:	NP_001285494.1	Gene:	tbc / 318059	FlyBaseID:	FBgn0052506	Length:	1155	Species:	Drosophila melanogaster
Sequence 2:	XP_011523474.1	Gene:	TBC1D3H / 729877	HGNCID:	30708	Length:	610	Species:	Homo sapiens

Alignment Length:	703	Identity:	137/703 - (19%)
Similarity:	219/703 - (31%)	Gaps:	239/703 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   341 AEEAEDI--------------DK--DAFWAYALNINVDEIVYVH-CHQSRGEDSGGTVILVGQDG 388
            |:|.|||              ||  ..|.:|  |.|||.:..|. |.........|..
Human    12 AQEREDIIMKYEKGHRAGLPEDKGPKPFRSY--NNNVDHLGIVQSCPSWESAPQEGPC------- 67

  Fly   389 VQRPPIHFPEGGHMQQFLSCLETGLLPHGQLD--PPLW-SQRGIGKMFLWPRSMRRRILPSVMES 450
               ||...|            ..||.|..:.|  .|.| |...:|.:   ........||.:..|
Human    68 ---PPFPVP------------SPGLSPELERDRASPFWGSAPRLGPL---QAPCSSSALPGLPYS 114

  Fly   451 VDETP------IDYVFRIVSKSRH--------EEFAATHSILD-FVRSTPRRAQLSSCSTTGSSD 500
            ..|.|      ...:.|.:|:...        |::.::..::| ..:..|...:....|..
Human   115 ETELPPLTAREAKQIRREISRKSKWVDMLGDWEKYKSSRKLIDRAYKGMPMNIRGPMWSVL---- 175

  Fly   501 CSNKSLSIDQFPMESP---LILQQQQQQQQQLLQAQSTSIEMVCSTMRRQIISRAFYGW------ 556
                 |:.::..:::|   .|::::.::..:.:|.....|.   .|:|:.:..|..||.
Human   176 -----LNTEEMKLKNPGRYQIMKEKGKRSSEHIQRIDRDIS---GTLRKHMFFRDRYGTKQRELL 232

  Fly   557 ------------LAYCRHLSTVRTHLSGLVHGRITPEMKADEEGLTKERWQLLNVNGVLENATEF 609
                        :.|||.||    |::.|.. ...||..|        .|.|:.:     .|:|.
Human   233 HILLAYEEYNPEVGYCRDLS----HIAALFL-LYLPEEDA--------FWALVQL-----LASER 279

  Fly   610 YRLVYFGGVQPELRQEVWPYLLGHYAFGSTTEDRKKQDETCKHYYETTMSEWLAVDAIVQQREKE 674
            :.|..|                 |...|.|.:..:.|.|   |...|:..:.:.     .|.:|:
Human   280 HSLQGF-----------------HSPNGGTVQGLQDQQE---HVVATSQPKTMG-----HQDKKD 319

  Fly   675 KTARA------VAKLSSGSNSGNDRTVRAADLEAGGDLENEVFEDISDISDPGDLEFDEQQQQQQ 733
            ...:.      :..|..|.:.|  .|:|..|:..   :|.|  :.:..|:   .:.|..||::..
Human   320 LCGQCSPLGCLIRILIDGISLG--LTLRLWDVYL---VEGE--QALMPIT---RIAFKVQQKRLT 374

  Fly   734 QQAECAVSGNHLTVKPIPRAMKTSTDSGHVDESFNELDEPDEEDNKQKQQQDEKISESESKLPDY 798
            :.:.|.         |..|......|:...||         :...|..:...:|::..:..||..
Human   375 KTSRCG---------PWARFCNRFVDTWARDE---------DTVLKHLRASMKKLTRKQGDLPPP 421

  Fly   799 RKLEEQINQEPSCSASTASSYETVGPGEVHQRPNSDTRSVLSPEYLSADDLQLPDDEDAVRPPPP 863
            .|.|:         .|:||            ||...:|   ..:.|...|.|        .||.|
Human   422 AKPEQ---------GSSAS------------RPVPASR---GGKTLCKGDRQ--------APPGP 454

  Fly   864 PAAAAVIITKASVDITNWERSPKAAEGDQMSPLEEQAGESGGAGVNMDALQQPKSACASPASSNG 928
            ||.....|..||        .|:|.......|        ||| |..|..........|||.:.|
Human   455 PARFPRPIWSAS--------PPRAPRSSTPCP--------GGA-VREDTYPVGTQGVPSPALAQG 502

  Fly   929 GVYSSELLEQFGLNLHRIEKDV-------------QRCDRNYWYFANENLDKL 968
            |...|....|:. ::.|:..|:             |.|    |..|....|:|
Human   503 GPQGSWRFLQWN-SMPRLPTDLDVEGPWFRHYDFRQSC----WVRAISQEDQL 550

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tbc	NP_001285494.1	RUN	45..218	CDD:280855
		PH_RUTBC	292..466	CDD:275431	34/150 (23%)
		TBC	923..1087	CDD:214540	14/59 (24%)
TBC1D3H	XP_011523474.1	TBC	160..373	CDD:214540	49/277 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900