Protein Alignment tbc and TBC1D3

DIOPT Version :9

• Sequence 1: NP_001285494.1
• Gene: tbc / 318059
• FlyBaseID: FBgn0052506
• Length: 1155
• Species: Drosophila melanogaster
• Sequence 2: NP_001116863.3
• Gene: TBC1D3 / 729873
• HGNCID: 19031
• Length: 549
• Species: Homo sapiens
• Alignment Length: 503
• Identity: 100/503 - (19%)
• Similarity: 163/503 - (32%)
• Gaps: 168/503 - (33%)

  Fly   506 LSIDQFPMESP---LILQQQQQQQQQLLQAQSTSIEMVCSTMRRQIISRAFYGW----------- 556
            |:.::..:::|   .|::::.::..:.:|.....   |..|:|:.|..|..||.
Human   115 LNTEEMKLKNPGRYQIMKEKGKRSSEHIQRIDRD---VSGTLRKHIFFRDRYGTKQRELLHILLA 176

  Fly   557 -------LAYCRHLSTVRTHLSGLVHGRITPEMKADEEGLTKERWQLLNVNGVLENATEFYRLVY 614
                   :.|||.||    |::.|.. ...||..|        .|.|:.:     .|:|.:.|..
Human   177 YEEYNPEVGYCRDLS----HIAALFL-LYLPEEDA--------FWALVQL-----LASERHSLQG 223

  Fly   615 FGGVQPELRQEVWPYLLGHYAFGSTTEDRKKQDETCKHYYETTMSEWLAVDAIVQQREKEKTARA 679
            |                 |...|.|.:..:.|.|   |...|:..:.:.     .|.:|:...:.
Human   224 F-----------------HSPNGGTVQGLQDQQE---HVVATSQPKTMG-----HQDKKDLCGQC 263

  Fly   680 ------VAKLSSGSNSGNDRTVRAADLEAGGDLENEVFEDISDISDPGDLEFDEQQQQQQQQAEC 738
                  :..|..|.:.|  .|:|..|:..   :|.|  :.:..|:   .:.|..||::..:.:.|
Human   264 SPLGCLIRILIDGISLG--LTLRLWDVYL---VEGE--QALMPIT---RIAFKVQQKRLTKTSRC 318

  Fly   739 AVSGNHLTVKPIPRAMKTSTDSGHVDESFNELDEPDEEDNKQKQQQDEKISESESKLPDYRKLEE 803
            .         |..|......|:...||         :...|..:...:|::..:..||...|.|:
Human   319 G---------PWARFCNRFVDTWARDE---------DTVLKHLRASMKKLTRKKGDLPPPAKPEQ 365

  Fly   804 QINQEPSCSASTASSYETVGPGEVHQRPNSDTRSVLSPEYLSADDLQLPDDEDAVRPPPPPAAAA 868
                     .|:||            ||...:|   ..:.|...|.|        .||.|||...
Human   366 ---------GSSAS------------RPVPASR---GGKTLCKGDRQ--------APPGPPARFP 398

  Fly   869 VIITKASVDITNWERSPKAAEGDQMSPLEEQAGESGGAGVNMDALQQPKSACASPASSNGGVYSS 933
            ..|..||        .|:|.......|        ||| |..|..........|||.:.||...|
Human   399 RPIWSAS--------PPRAPRSSTPCP--------GGA-VREDTYPVGTQGVPSPALAQGGPQGS 446

  Fly   934 ELLEQFGLNLHRIEKDV-------------QRCDRNYWYFANENLDKL 968
            ....|:. ::.|:..|:             |.|    |..|....|:|
Human   447 WRFLQWN-SMPRLPTDLDVEGPWFRHYDFRQSC----WVRAISQEDQL 489

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tbc	NP_001285494.1	RUN	45..218	CDD:280855
		PH_RUTBC	292..466	CDD:275431
		TBC	923..1087	CDD:214540	14/59 (24%)
TBC1D3	NP_001116863.3	TBC	99..312	CDD:214540	48/252 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	350..419		24/116 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900