DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tbc and Tbc1d5

DIOPT Version :9

Sequence 1:	NP_001285494.1	Gene:	tbc / 318059	FlyBaseID:	FBgn0052506	Length:	1155	Species:	Drosophila melanogaster
Sequence 2:	NP_001272920.1	Gene:	Tbc1d5 / 72238	MGIID:	1919488	Length:	837	Species:	Mus musculus

Alignment Length:	264	Identity:	59/264 - (22%)
Similarity:	103/264 - (39%)	Gaps:	64/264 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   913 LQQPKSACA-------SPASSNGGVYSSELLEQFGLNLHRIEKDVQRCDRNYWYFANENLDK-LR 969
            :..|:.|..       :|.|.:.|...::..:...|. ..||:||:|......:|..||:.| |.
Mouse   124 ITNPRKAAGQQDLMINNPLSQDEGSLWNKFFQDKELR-SMIEQDVKRTFPEMQFFQQENVRKILT 187

  Fly   970 NVISTYVWEHLDVGYMQGMCDLVAPLL------------------------VIFDDESL---SYS 1007
            :|:..|..|:..:.|.|||.:|:||::                        .:.:.|.|   :|:
Mouse   188 DVLFCYARENEQLLYKQGMHELLAPIIFTLHCDHQAFLHASESAQPSEEMKTLLNPEYLEHDAYA 252

  Fly  1008 CFCKLMER---MIENFPSGG-------AMDMHFANMRSL---IQILD--SEMYDLMDSNGD---Y 1054
            .|.:|||.   ....|...|       ...:.||..:.|   :.|:.  :::.|.:....|   |
Mouse   253 MFSQLMETAEPWFSTFEHDGQKGKETLMAPIPFARPQDLGPTVAIVTKVNQIQDHLLKKHDIELY 317

  Fly  1055 THF--------YFCYRWFLLDFKRELVYDDVFATWEVIWAAKHIASGHFVLFLALALLETYRDII 1111
            .|.        .:..||..|.|.||....|:...|:.::|.....|  .|.::..|:|...||.:
Mouse   318 MHLNRLEIAPQIYGLRWVRLLFGREFPLQDLLVVWDALFADSLNLS--LVDYVFTAMLLYIRDAL 380

  Fly  1112 LSNS 1115
            :|::
Mouse   381 ISSN 384

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tbc	NP_001285494.1	RUN	45..218	CDD:280855
		PH_RUTBC	292..466	CDD:275431
		TBC	923..1087	CDD:214540	49/217 (23%)
Tbc1d5	NP_001272920.1	TBC	79..381	CDD:214540	58/259 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900