Protein Alignment tbc and Tbc1d9

DIOPT Version :9

• Sequence 1: NP_001285494.1
• Gene: tbc / 318059
• FlyBaseID: FBgn0052506
• Length: 1155
• Species: Drosophila melanogaster
• Sequence 2: NP_001104774.1
• Gene: Tbc1d9 / 71310
• MGIID: 1918560
• Length: 1264
• Species: Mus musculus
• Alignment Length: 730
• Identity: 143/730 - (19%)
• Similarity: 253/730 - (34%)
• Gaps: 239/730 - (32%)

  Fly   539 MVCSTMRRQIISRAFYGW--------LAYCRHLSTVRTHLSGLVHGRITP-----EMKADEE--- 587
            :.|...|:::...  :.|        |:...:.:.|.|.:.|.:.|.|..     ::|.||:
Mouse    78 IACGGSRKEVTEH--WEWLEQNLLQTLSIFENENDVTTFVRGKIQGIIAEYNKINDVKEDEDTEK 140

  Fly   588 ------------GLTKERWQLLNVNGVLENATEFYRLVYFGGVQPELRQEVWPYL-LGHYAFGST 639
                        |:.:|           |....:|...|:.|..|   ::.|.|| :.|..|.|.
Mouse   141 FKEAIVKFHRLFGMPEE-----------EKLVNYYSCSYWKGRVP---RQGWMYLSINHLCFSSF 191

  Fly   640 TEDR--------------------------KKQDETCKHYYETTMS--------EWLAVDAIVQQ 670
            ...|                          |....:.:|::...::        |.||..|:.|.
Mouse   192 LMGREAKLVIRWVDITQLEKNATLLLPDMIKVSTRSSEHFFSVFLNINETFKLMEQLANIAMRQL 256

  Fly   671 REKE--KTARAVAKLSSGSNSGNDRTVRAADLEAGGDLENEVFEDISDISDPGDLEFDEQQQQQQ 733
            .:.|  :..|::.||...|........|..|..|..:....:|.      .|.|.:.|
Mouse   257 LDNEGFEQDRSLPKLKKKSPKKVSALKRDLDARAKSERYRALFR------LPKDEKLD------- 308

  Fly   734 QQAECA---------------VSGNHL--TVKP-------IPRAMKTSTDSGHVDESFNELDEPD 774
            ...:|.               ||.|::  |.|.       ||....|..:..   :|.:.|..|.
Mouse   309 GHTDCTLWTPFNKMHILGQMFVSTNYICFTSKEENLCSLIIPLREVTIVEKA---DSCSVLPSPL 370

  Fly   775 EEDNKQK--------QQQDEKISESESKLPDY-RKLEEQINQEPSCSASTASSYETVGPGEVHQR 830
            ....:.:        :.:|..:    .::.|: ::...:|..:...|.|..||.:     ||:.|
Mouse   371 SISTRNRMTFLFANLKDRDFLV----QRISDFLQQTTSRIYSDKEFSGSCNSSDD-----EVYSR 426

  Fly   831 PNSDTRSVLSPEYLSADDLQLPDDEDAVRP-----PPPPAAAAVIITKASVDITNWERSPKAAEG 890
            |:|...|  ||:..::      .|.|..||     ...|.|...::|...      .|||
Mouse   427 PSSLVSS--SPQRSTS------SDADGERPFNLNGNSVPTATQTLMTMYR------RRSP----- 472

  Fly   891 DQMSP------LEEQAGE----SGGAGVNMDALQQPKSACAS--PASSNGGV------------- 930
            ::.:|      |:|||.:    ..|.|:.|...::.:.....  |.|..|.:
Mouse   473 EEFNPKLAKEFLKEQAWKIHFAEYGQGICMYRTEKTRELVLKGIPESMRGELWLLLSGAINEKAT 537

  Fly   931 ---YSSELLE----QFGLNLHRIEKDVQRCDRNYWYFANE-NLDKLRNVISTYVWEHLDVGYMQG 987
               |...|:|    ::.|....||:|:.|....:..|.|| .:..||.|::.|.:.:.::||.|.
Mouse   538 HPGYYEGLVEKSMGKYNLATEEIERDLHRSLPEHPAFQNEMGIAALRRVLTAYAFRNPNIGYCQA 602

  Fly   988 MCDLVAPLLVIFDDESLSYSCFCKLMERMIENFPSGGAMDMHFANMRSLIQILDSEMYDLMDSNG 1052
            | ::|..:|:::..|..::.....|.|||:.:          :.|.|.:..::|..:::  :...
Mouse   603 M-NIVTSVLLLYAKEEEAFWLLVALCERMLPD----------YYNTRVVGALVDQGVFE--ELAR 654

  Fly  1053 DYT-HFYFCYR-----------WFL------LDFKRELVYDDVFATWEVIWAAKHIASGHFVLF- 1098
            ||. ..|.|.:           |||      :.|:..:|..|.|           ...|..|:|
Mouse   655 DYVPQLYDCMQDLGVISTISLSWFLTLFLSVMPFESAVVVVDCF-----------FYEGIKVIFQ 708

  Fly  1099 LALALLETYRDIILS 1113
            ||||:|:...|.:|:
Mouse   709 LALAVLDANVDKLLN 723

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tbc	NP_001285494.1	RUN	45..218	CDD:280855
		PH_RUTBC	292..466	CDD:275431
		TBC	923..1087	CDD:214540	43/202 (21%)
Tbc1d9	NP_001104774.1	PH-GRAM1_TCB1D9_TCB1D9B	157..255	CDD:275420	19/111 (17%)
		PH-GRAM2_TCB1D9_TCB1D9B	304..399	CDD:270161	16/108 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	410..456		16/58 (28%)
		TBC	512..722	CDD:214540	52/233 (22%)
		EFh	<893..923	CDD:298682
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1119..1162

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900