DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tbc and Tbc1d13

DIOPT Version :9

Sequence 1:	NP_001285494.1	Gene:	tbc / 318059	FlyBaseID:	FBgn0052506	Length:	1155	Species:	Drosophila melanogaster
Sequence 2:	NP_666364.1	Gene:	Tbc1d13 / 70296	MGIID:	2385326	Length:	400	Species:	Mus musculus

Alignment Length:	377	Identity:	79/377 - (20%)
Similarity:	137/377 - (36%)	Gaps:	87/377 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   801 LEEQINQEPSCSASTASSYETVGPGEVHQRPNSDTRSVLSPEYLSADDLQLPDDEDAVRPPPPPA 865
            |.|.|.|.....|:.....|.|...:....||.|:|   ...|...:::.|..|:|..|..|
Mouse    74 LREMIIQPGIAKANMGVFREDVTFEDHPLNPNPDSR---WNTYFKDNEVLLQIDKDVRRLCP--- 132

  Fly   866 AAAVIITKASVDITNWERSPK---------------AAEGDQMSPLEEQAGESGGAGVNMDALQQ 915
                       ||:.::|:.:               ..:..:.:.|:.|......:||...:...
Mouse   133 -----------DISFFQRATEYPCLLILDPQNEFETLRKRVEQTTLKSQTVARNRSGVTNMSSPH 186

  Fly   916 PKSACASPASSNGGVYSSELLEQFGLNLHRIEKDVQRCDRNYWYFANENLDKLRNVISTYVWEHL 980
            ..||   |::.|    ..|:|.. |...|             |       :.:..::..|...:.
Mouse   187 KNSA---PSALN----EYEVLPN-GCEAH-------------W-------EVVERILFIYAKLNP 223

  Fly   981 DVGYMQGMCDLVAPLLVIF----------DDESLSYSCFCKLMERMIENF-----PSGGAMDMHF 1030
            .:.|:|||.::|.||...|          ..|:.::.||..||..:.:||     .|...:....
Mouse   224 GIAYVQGMNEIVGPLYYTFATDPNSEWKEHAEADTFFCFTNLMAEIRDNFIKSLDDSQCGITYKM 288

  Fly  1031 ANMRSLIQILDSEMYDLMDSNGDYTHFYFCYRWFLLDFKRELVYDDVFATWEVIWAAKHIASGH- 1094
            ..:.|.::..|.|:|..:........| |.:||..|...:|.:..||...|:.::     |.|:
Mouse   289 EKVYSTLKDKDVELYLKLQEQSIKPQF-FAFRWLTLLLSQEFLLPDVIRIWDSLF-----ADGNR 347

  Fly  1095 --FVLFLALALLETYRDIILSNSMDFTDVIKFFNEMAERHNAQSVLQLARSL 1144
              |:|.:..|:|...|:.:|..  |||..::...:.......| :||.|:.|
Mouse   348 FDFLLLVCCAMLILIREQLLEG--DFTVNMRLLQDYPITDVCQ-ILQKAKEL 396

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tbc	NP_001285494.1	RUN	45..218	CDD:280855
		PH_RUTBC	292..466	CDD:275431
		TBC	923..1087	CDD:214540	37/178 (21%)
Tbc1d13	NP_666364.1	TBC	32..367	CDD:214540	70/343 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900