Protein Alignment tbc and Tbc1d8

DIOPT Version :10

• Sequence 1: NP_608395.6
• Gene: tbc / 318059
• FlyBaseID: FBgn0052506
• Length: 1155
• Species: Drosophila melanogaster
• Sequence 2: XP_006244913.1
• Gene: Tbc1d8 / 680133
• RGDID: 1595491
• Length: 1150
• Species: Rattus norvegicus
• Alignment Length: 756
• Identity: 137/756 - (18%)
• Similarity: 246/756 - (32%)
• Gaps: 247/756 - (32%)

  Fly   564 STVRTHLSGLVHGRITPEMKADEEGLTKERWQLLNVNG-----VLENATEFYRLVYFGGVQPELR 623
            |.|:..:..|:....:..:...||...|.|..|:....     ..|....:|....:.|..|
  Rat   127 SFVKGKVKALIAEETSSRLAEQEEEPEKFREALVKFEARFNFPEAEKLVTYYSCCCWKGRVP--- 188

  Fly   624 QEVWPYL-LGH---YAFGSTTE--------DRKKQDETCKHYYETTM-----------SEWLAVD 665
            ::.|.|| :.|   |:|....|        |.:|.:.|...:...|:           |.:|.:|
  Rat   189 RQGWLYLSINHLCFYSFFLGKELKLVIPWVDIQKLERTSNVFLTDTIRITTQNKERDFSTFLNLD 253

  Fly   666 AIVQQREKEKTARAVAKLSSGSNSGNDRTVRAADLEAGGDLENEVFEDISDISDPG-----DLEF 725
            .:.:..|                       :.||:.....|:||||:...|:.:|.     |||.
  Rat   254 EVFKIME-----------------------QLADVTLRRLLDNEVFDLDPDLQEPSQITKRDLEA 295

  Fly   726 DEQQQ--------QQQQQAECAVSGNHLTVKPIPRAMKTSTDSGHVDESFNELDEPDEEDN---- 778
            ..|.:        .::::....|..:..|  |..|.    ..:|.:..|.:.:.....||.
  Rat   296 RAQNEFFRAFFRLPRKEKLHAVVDCSLWT--PFSRC----HTAGRIFSSDSYICFASREDGCCHV 354

  Fly   779 ---KQKQQQDEKISESESKLPD-------------YRKLEEQIN-------QEPSCSASTASSYE 820
               .::....||: |..|.||:             :.:|:::.|       :.....|:....||
  Rat   355 VLPLREVVSIEKM-EDTSLLPNPIIVSIRSKMAFQFIELKDRENLVEGLLLRLKQVHANHPVHYE 418

  Fly   821 TVGPGEVHQRPNSDTRSVLSPEYLSAD-------DLQL--------PDDEDAVRPPPPPAAAAV- 869
            |        .|:.|  .:.||.:.|..       ||::        .:.|.:..|.|.|..|..
  Rat   419 T--------SPSDD--DMASPVFYSTSICTDKFGDLEMVSSQSSEEREKEKSPLPHPEPLTAVFQ 473

  Fly   870 ---------IITKASVDITNWE-------------RSPKAAEGDQMSPLEEQAGESGGAGVNMDA 912
                     .:::..:.|:.|.             |:.|..:...|...|...|.
  Rat   474 QSGSQSPDSRLSREQIKISLWNDHFAEYGRTVCMFRTEKIRKLVAMGIPESLRGR---------- 528

  Fly   913 LQQPKSACASPASSNGGVYSSELLEQFG---LNLHRIEKDVQRCDRNYWYFANE-NLDKLRNVIS 973
            |....|...:..:|:.|.|.:.:.:..|   |....||:|:.|....:..|.|| .:..||.|::
  Rat   529 LWLLFSDAVTDLASHPGYYGNLVEQSLGRCCLVTEEIERDLHRSLPEHPAFQNETGIAALRRVLT 593

  Fly   974 TYVWEHLDVGYMQGMCDLVAPLLVIFDDESLSYSCFCKLMERMIENFPS----GGAMDMHFANMR 1034
            .|...:..:||.|.| :::..:|:::..|..::.....:.|||:.::.:    |..:|.....
  Rat   594 AYAHRNPKIGYCQSM-NILTSVLLLYAKEEEAFWLLVAVCERMLPDYFNHRVIGAQVDQSVFE-- 655

  Fly  1035 SLIQILDSEMYDLMDSNGDYTHF-YFCYRWFLLDFKREL------------VYDDVFATWEVIWA 1086
               :::...:.:|.:...|.:.. .....|||..|...:            .||.:.|.::
  Rat   656 ---ELIKEHLPELAEHMSDLSALASISLSWFLTLFLSIMPLESAVNVVDCFFYDGIKAIFQ---- 713

  Fly  1087 AKHIASGHFVLFLALALLETYRD------------IILSNSMD---------------------- 1117
                        |.||:||...:            :|||..:|
  Rat   714 ------------LGLAVLEANAEELCSSKDDGQALMILSRFLDHIKNEDSPGPPIGSHHAFFSDD 766

  Fly  1118 -----FTDVIKFFNEMAERHNAQSVLQLA------RSLVLQ 1147
                 .||:.....:..|:...|||.|:.      |..|||
  Rat   767 QEPCPVTDIADLIRDSYEKFGNQSVEQIEHLRCKHRIRVLQ 807

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tbc	NP_608395.6	RUN_SGSM1_like	21..214	CDD:439049
		PH_RUTBC	292..466	CDD:275431
		TBC	923..1087	CDD:214540	36/184 (20%)
Tbc1d8	XP_006244913.1	PH-GRAM1_TBC1D8	171..269	CDD:270156	21/123 (17%)
		PH-GRAM2_TBC1D8	311..406	CDD:270160	16/101 (16%)
		TBC	520..726	CDD:214540	45/237 (19%)