DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tbc and Tbc1d2b

DIOPT Version :9

Sequence 1:	NP_001285494.1	Gene:	tbc / 318059	FlyBaseID:	FBgn0052506	Length:	1155	Species:	Drosophila melanogaster
Sequence 2:	NP_919315.2	Gene:	Tbc1d2b / 67016	MGIID:	1914266	Length:	965	Species:	Mus musculus

Alignment Length:	1051	Identity:	199/1051 - (18%)
Similarity:	347/1051 - (33%)	Gaps:	338/1051 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   266 GTGSFKSIASASVAKD------YVESL---------------HQNAKATLLYGKNNVQVLP---- 305
            |||   |.|.|...::      |::.|               ..:.:..|.|.|:....||
Mouse    21 GTG---SEAGAVAGREPSRLCGYLQKLSGKGPLRGYRSRWFVFDSRRCYLYYFKSPQDALPLGHL 82

  Fly   306 ------------KDVAEP---MPGYLSLHQHIQTLTIKWTPNQLMNGY--TEAEEAEDIDKDAFW 353
                        .:.|||   .|.:..:|. ...:|:...||:.:..|  .|.::..       |
Mouse    83 DIADACFSYQGRDEAAEPGADPPTHFQVHS-AGAVTVLKAPNRELMTYWLQELQQKR-------W 139

  Fly   354 AYALNINV---------------------DEIVYVHCHQSRGEDSGGTVI--------LVGQDGV 389
            .|..::::                     |....:..|.:...:...||:        |||....
Mouse   140 EYCNSLDMMKWDSRTSPTPGDFPKGLVARDTTDIISQHPNPSAEKARTVLAVEAAPGELVGDRAA 204

  Fly   390 QRP------PIHFPE----GGHMQQFLSCLETGLLPHGQ--------------LDPPLWSQRGIG 430
            .:|      ||:|..    |..::..:|....| ..|.:              ||||
Mouse   205 HQPAPGHPNPINFYSLKQWGNELKNSMSSFRPG-RGHSESRRTVFYTNEEWELLDPP-------- 260

  Fly   431 KMFLWPRSM--------RRRILPSVMESVDETPIDYVFRIVSKSRHEEFAATHSILDFVRSTPRR 487
                 |:.:        |::.:|...:.|..:...:.|      ....:.....:.|.:.|...|
Mouse   261 -----PKDLEESLVPEERKKPMPEGSKGVASSGFPFEF------GRNPYKGKRPLKDIIGSYKNR 314

  Fly   488 AQLSSCSTTGSSDCSNKSLSIDQFPMESPLILQQQQQQQQQL---LQAQSTSIEMVCSTMRRQII 549
            ...|.....|::..|..|....:...|..|.:|.||::.:||   |.:|...|.::..|:|....
Mouse   315 HSSSDPLLEGTATSSGSSGGPTKPVPEMQLQIQSQQEELEQLKKDLSSQKELIRLLQQTVRSSQY 379

  Fly   550 SRAFYGWLAYCRHLSTVRTHLSGLVHGRITPEMKADE-EGLTKERWQLLNVNGVLENATEFYRLV 613
            .:.|                    .:.:|:..:..|. |.|.::..|:|.::|.||.
Mouse   380 DKYF--------------------TNPQISQGVPGDTLELLHQKDEQILGLSGQLER-------- 416

  Fly   614 YFGGVQPELRQEV--WPYLLG--HYAFGSTTEDRKKQDE------TCKHYYETTM---SEWLAVD 665
             ||..:..|:|||  ....:|  :...|...|..:.:||      .|:....:..   |..||:.
Mouse   417 -FGLEKESLQQEVRTLKSKVGELNERLGMLMETIQAKDEVIIKLSACEGSVSSPTLGPSSPLAIP 480

  Fly   666 AIVQQREKEKTA--------------RAVAKLS----SGSNSGNDRTVRAADLEAG-GDLENEVF 711
            |...|.|.::..              :.:.:||    :......|...:.:.|||. ..:|::..
Mouse   481 ASKDQLELDRLKDSLQGYKSQNKFLNKEILELSALRRNAERRERDLMAKYSSLEAKLCQVESKYL 545

  Fly   712 EDISDISDP-------------GDLEFDEQQQQQQQQAECAVSGNHLTVKPIPRAMKTSTDSGHV 763
            ..:.::..|             ..|..|..|.:.|:|.|.|....||                 |
Mouse   546 ILLQEMKTPVCSEEQGPARDVIAQLLEDALQVESQEQPEQAFVKPHL-----------------V 593

  Fly   764 DE----SFNELDEPDEEDNKQKQQQDEKISESESKLPDYRKLEEQINQEPSCSASTASSYETVGP 824
            .|    .|..:.:.|||         ||:......| |.:.|....|||    .||...:|....
Mouse   594 SEFDIYGFRTVPDDDEE---------EKLVAKVRAL-DLKTLYLTDNQE----VSTGVKWENYFA 644

  Fly   825 GEVHQRPNSDTRSVLSPEYLSADDLQLPDDEDAVRPPPPPAAAAVIITKASVDITNWERSPKAAE 889
            ..:::      ....|||..:.....:|.:..:.            :.|..|| .:..:...:.|
Mouse   645 STMNR------EMACSPELKNLIRAGIPHEHRSK------------VWKWCVD-RHTRKFKDSME 690

  Fly   890 GDQMSPLEEQAGESGGAGVNMDALQQPKSACASPASSNGGVYSSELLEQFGLNLHRIEKDVQRC- 953
            .|....|.::|.|.                 .:|||.                  :||.|:.|.
Mouse   691 PDYFQTLLQKALEK-----------------QNPASK------------------QIELDLLRTL 720

  Fly   954 --DRNYWYFANENLDKLRNVISTYVWEHLDVGYMQGMCDLVAPLLVIFDDESLSYSCFCKLMERM 1016
              :::|....:|.:.|||:|:..:.|.:.|:||.||:..|||..|:..|.|. ::.|...::|..
Mouse   721 PNNKHYSSPTSEGIQKLRSVLLAFSWRNPDIGYCQGLNRLVAVALLYLDQED-AFWCLVTIVEVF 784

  Fly  1017 IENFPSGGAMDMHFANMRSLIQILDSEMY-DLMDSNGDYTHFYF----------CYRWFLLDFKR 1070
                     |...:.....|...:|..:: ||:.......|.:|          .:.|||:.|..
Mouse   785 ---------MPRDYYTKTLLGSQVDQRVFRDLLSEKLPRLHTHFEQYKVDYTLITFNWFLVVFVD 840

  Fly  1071 ELVYDDVFATWEVIWAAKHIASGHFVLF-LALALLETYRDIILSNSMDFTDVIKFFNEMAERHNA 1134
            .:|.|.:|..|:     ..:..|..|:| .||||.: |::..:....|...:.|:.     |:..
Mouse   841 SVVSDILFKIWD-----SFLYEGPKVIFRFALALFK-YKEEEILKLQDSMSIFKYL-----RYFT 894

  Fly  1135 QSVLQLARSLV 1145
            :::|. ||.|:
Mouse   895 RTILD-ARKLI 904

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tbc	NP_001285494.1	RUN	45..218	CDD:280855
		PH_RUTBC	292..466	CDD:275431	41/255 (16%)
		TBC	923..1087	CDD:214540	42/177 (24%)
Tbc1d2b	NP_919315.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..27		4/8 (50%)
		PH_TBC1D2A	36..144	CDD:269966	19/115 (17%)
		PH	38..136	CDD:278594	17/98 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	257..288		8/43 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	310..340		6/29 (21%)
		HIP1_clath_bdg	<341..>378	CDD:293123	12/36 (33%)
		RabGAP-TBC	710..878	CDD:278964	47/201 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900