DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tbc and TBC1D15

DIOPT Version :9

Sequence 1:	NP_001285494.1	Gene:	tbc / 318059	FlyBaseID:	FBgn0052506	Length:	1155	Species:	Drosophila melanogaster
Sequence 2:	XP_006719627.1	Gene:	TBC1D15 / 64786	HGNCID:	25694	Length:	699	Species:	Homo sapiens

Alignment Length:	467	Identity:	112/467 - (23%)
Similarity:	194/467 - (41%)	Gaps:	113/467 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   752 RAMKTSTDSGHVDESF-NELDEPDEEDNKQKQQQDEKISESESKLPDYRKL------EEQINQEP 809
            |.:..:..:..:.:|| |.||||             .....::.|.|.|||      .::|.::|
Human   199 RTLLVNCQNKSLSQSFENLLDEP-------------AYGLIQAGLLDRRKLLWAIHHWKKIKKDP 250

  Fly   810 ------SCSASTASSYETVGPGE--VHQRPNSDTRSVLSPEYLSADDLQLPDDED---------- 856
                  ..|..|...::::...:  .||||.|:....||.   :...|::...|:
Human   251 YTATMIGFSKVTNYIFDSLRGSDPSTHQRPPSEMADFLSD---AIPGLKINQQEEPGFEVITRID 312

  Fly   857 -AVRPPPPPAAAAVIITKASVDITNWERSPKAAEGDQMSPLEEQAGESGGAGVNMDALQQ----- 915
             ..||        |:..:..|.:..|.::.                :|.|..:|:|.::|
Human   313 LGERP--------VVQRREPVSLEEWTKNI----------------DSEGRILNVDNMKQMIFRG 353

  Fly   916 ------PKSACA---------SPASSNGGVYSSELLEQFGLNLH--------------------R 945
                  .|.|..         |.......:...:..|.|.:.|.                    .
Human   354 GLSHALRKQAWKFLLGYFPWDSTKEERTQLQKQKTDEYFRMKLQWKSISQEQEKRNSRLRDYRSL 418

  Fly   946 IEKDVQRCDR-NYWYFANEN--LDKLRNVISTYVWEHLDVGYMQGMCDLVAPLLVIFDDESLSYS 1007
            |||||.|.|| |.:|...:|  |..|.:::.||.....|:||:|||.||::|||.:.::|..::.
Human   419 IEKDVNRTDRTNKFYEGQDNPGLILLHDILMTYCMYDFDLGYVQGMSDLLSPLLYVMENEVDAFW 483

  Fly  1008 CFCKLMERMIENFPSG-GAMDMHFANMRSLIQILDSEMYDLMDSNGDYTHFYFCYRWFLLDFKRE 1071
            ||...|::|.:||... ..|......:.:|:::|||.....::|. |..:.|||:||.|:.||||
Human   484 CFASYMDQMHQNFEEQMQGMKTQLIQLSTLLRLLDSGFCSYLESQ-DSGYLYFCFRWLLIRFKRE 547

  Fly  1072 LVYDDVFATWEVIWAAKHIASGHFVLFLALALLETYRDIILSNSMDFTDVIKFFNEMAERHNAQS 1136
            ..:.|:...|||:|.  .:...:|.|.|..|:||:.:..|:.....|.:::|..||::.:.:.:.
Human   548 FSFLDILRLWEVMWT--ELPCTNFHLLLCCAILESEKQQIMEKHYGFNEILKHINELSMKIDVED 610

  Fly  1137 VLQLARSLVLQL 1148
            :|..|.::.||:
Human   611 ILCKAEAISLQM 622

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tbc	NP_001285494.1	RUN	45..218	CDD:280855
		PH_RUTBC	292..466	CDD:275431
		TBC	923..1087	CDD:214540	58/187 (31%)
TBC1D15	XP_006719627.1	DUF3548	19..227	CDD:192931	8/40 (20%)
TBC1D15	XP_006719627.1	TBC	351..586	CDD:214540	67/237 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810