DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tbc and tbc1d30

DIOPT Version :9

Sequence 1:	NP_001285494.1	Gene:	tbc / 318059	FlyBaseID:	FBgn0052506	Length:	1155	Species:	Drosophila melanogaster
Sequence 2:	XP_021331078.1	Gene:	tbc1d30 / 569334	ZFINID:	ZDB-GENE-030131-2064	Length:	1063	Species:	Danio rerio

Alignment Length:	493	Identity:	99/493 - (20%)
Similarity:	178/493 - (36%)	Gaps:	136/493 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   683 LSSGSN-----SGNDRTVRAADLEAGGDLENEVFEDISDISDPGDLEFDEQQQQQQQQA---ECA 739
            ||:|::     ||..:.|...:: :.||.|........: .:.|.|.||.::.:..:.:   :|.
Zfish    30 LSAGASYLDGFSGFHKWVSKIEV-SDGDCEKTSSRKAHE-EEKGGLYFDREELKDSRASSLVDCL 92

  Fly   740 VSGNHLTVKPIPRAMKTSTDSGHVD---------ESF-NELDEPDEEDNKQK------------- 781
            :...:.|.......:.:||::...|         .|| .||.|.....::.|
Zfish    93 LVELYDTYSHGVPGLDSSTEASSSDAFLGRSNSGSSFLQELQEKHTRRHQVKYLAQKGPEELKWI 157

  Fly   782 -QQQDEKISESESKLPDYRKLEEQINQ--EPSCSASTASSYETVGPGEVHQRPNSDTR--SVLSP 841
             |:...:|:...:||....|.::::.|  :.:|...||...      .|.|:...|||  ..:.|
Zfish   158 VQEVKYRIAVQSAKLVRQAKRKDRLRQKFQKNCDIVTACLQ------AVSQKRRVDTRLKFTIEP 216

  Fly   842 EYLSADDLQLPDDEDAV-RPP---PPPAAAAVIITKA-----SVDITNWERSPKAAEGDQMSPLE 897
            ........|..|...|| |.|   |......|.:|.|     |:.| :||::.:.|..|:.:|.:
Zfish   217 SLGKNGFQQWYDALKAVARLPVGIPKEWRKRVWLTLADQYLHSISI-DWEKTMRFAFNDRSNPDD 280

  Fly   898 EQAGESGGAGVNMDALQQPKSACASPASSNGGVYSSELLEQFGLNLHRIEKDVQR--CDRNYWYF 960
            :..|                                          .:|.||:.|  |.......
Zfish   281 DSLG------------------------------------------IQIVKDLHRTGCSSYCGQE 303

  Fly   961 ANENLDKLRNVISTYVWEHLDVGYMQGMCDLVAPLLVIFD-DESLSYSCFCKLMERMIENFPSGG 1024
            |.::...|:.|:..|...:..|||.||...|.|.:|.:.: :|..:......|:::::.
Zfish   304 AEQDRVVLKRVLLAYARWNKTVGYCQGFNVLAALILEVTEGNEGDALKVMIYLIDKVLP------ 362

  Fly  1025 AMDMHFAN-----------MRSLIQI----LDSEMYDLM-----DSNGDY----THFYFCYRWFL 1065
              |.:|||           .|.|:::    |...::.|.     ::.|.|    |: .|..:|||
Zfish   363 --DSYFANNLRALSVDMAVFRDLLRLKLPELSQHLHHLQKVANREAGGSYEPPLTN-VFTMQWFL 424

  Fly  1066 LDFKRELVYDDVFATWEVIWAAKHIASGHFVLFLALAL 1103
            ..|...|.:..|...|:.::    ......:|.:|||:
Zfish   425 TMFATCLPHHTVLKIWDSVF----FEGSEMLLRVALAI 458

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tbc	NP_001285494.1	RUN	45..218	CDD:280855
		PH_RUTBC	292..466	CDD:275431
		TBC	923..1087	CDD:214540	38/190 (20%)
tbc1d30	XP_021331078.1	TBC	239..458	CDD:214540	53/274 (19%)
		DUF4682	625..775	CDD:318030
		HrpB7	733..>820	CDD:330448
		Herpes_BLLF1	<825..>973	CDD:330317
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900