Protein Alignment tbc and tbc1d9

DIOPT Version :9

• Sequence 1: NP_001285494.1
• Gene: tbc / 318059
• FlyBaseID: FBgn0052506
• Length: 1155
• Species: Drosophila melanogaster
• Sequence 2: XP_692034.2
• Gene: tbc1d9 / 563578
• ZFINID: ZDB-GENE-060810-33
• Length: 1248
• Species: Danio rerio
• Alignment Length: 725
• Identity: 144/725 - (19%)
• Similarity: 249/725 - (34%)
• Gaps: 205/725 - (28%)

  Fly   566 VRTHLSGLVHGRITPEMKA------DEEGLTKE---RWQLLNVNGVLENATEFYRLVYFGGVQPE 621
            :.|.:.|.:.|.|....|:      |:....||   :::.|.|....|....:|...|:.|..|
Zfish   108 ITTFVKGKIQGIIAEYNKSHDIKEDDDTDKFKEAIAKFRKLFVMPEEEKLVNYYSCSYWKGKVP- 171

  Fly   622 LRQEVWPYL-LGHYAFGS---------------TTE----------DRKKQDETC-KHYYETTMS 659
              ::.|.|| :.|..|.|               .|:          |..:....| :|.:...::
Zfish   172 --RQGWLYLSINHICFYSYLLGKEVKLVVRWADVTQLEKSATLLLPDMVRVSTRCSEHVFSVFLN 234

  Fly   660 --------EWLAVDAIVQQREKE--KTARAVAKLSSGSNSGNDRTVRAADLEAGGDLENEVFEDI 714
                    |.||..|:.|..:.:  :..|::.||...|........|..|..|..:....:|.
Zfish   235 INETFKLMEQLANIAMRQLLDNKGFEQDRSLPKLKKKSPKKVSALKRDLDARAKSERYRALFR-- 297

  Fly   715 SDISDPGDLEFDEQQQQQQQQAECA---------------VSGNHL--TVKP-------IPRAMK 755
                .|.|.:.|       ...:|.               ||.|::  |.|.       ||....
Zfish   298 ----LPKDEKLD-------GHTDCTLWTPFNKMHILGQMFVSTNYICFTSKEETVCSLIIPLREV 351

  Fly   756 TSTDSGHVDESFNELDEPDEEDNKQK---------------QQQDEKISESESKLPDYRKLEEQI 805
            |..:..   :|.|.|..|.....|.|               |:..:.:.::.||:...|::
Zfish   352 TIVEKA---DSSNVLPSPLSISTKNKMTFLFANLKDRDFLVQRISDFLQQTTSKIYFEREI---- 409

  Fly   806 NQEPSCSASTASSYETVGPGEVHQRPNSDTRSVLSPEYLSADDLQLPDDEDAVRPPPPPAAAAVI 870
                  :.|.:||.:.|...:......|..||.|..|..|.....|.|:    |.|....|...:
Zfish   410 ------TGSLSSSDDEVYSQQGSVLSCSPQRSALVSEGESERQFNLNDN----RVPTATQALMTM 464

  Fly   871 ITKASVDITNWERSPKAAEGDQMSPLEEQAGESG----GAGVNMDALQQPK-------------- 917
            ..:.|.:    |.:||.|:    ..|:|||.::.    |.||.|....:.|
Zfish   465 YRRRSPE----EFNPKLAK----EFLKEQAWKNHFTEYGQGVCMYRTDKTKDLVLQGIPENMRGE 521

  Fly   918 -----SACASPASSNGGVYSSELLE----QFGLNLHRIEKDVQRCDRNYWYFANE-NLDKLRNVI 972
                 |...:..:::.|.| .:|:|    ::.|....||:|:.|....:..|.|| .:..||.|:
Zfish   522 LWLLFSGAINEMATHPGYY-EDLVEKSMGKYNLATEEIERDLHRSLPEHPAFQNEMGIAALRRVL 585

  Fly   973 STYVWEHLDVGYMQGMCDLVAPLLVIFDDESLSYSCFCKLMERMIENFPS----GGAMDMHFANM 1033
            :.|.:.:.::||.|.| ::|..:|:::..|..::.....:.|||:.::.:    |..:|.  ...
Zfish   586 TAYAFRNPNIGYCQAM-NIVTSVLLLYAKEEEAFWLLVAMCERMLPDYYNTRVVGALVDQ--GVF 647

  Fly  1034 RSLIQILDSEMYDLMDSNGDYTHFYFCYRWFL------LDFKRELVYDDVFATWEVIWAAKHIAS 1092
            ..|..:...::||.|.:.|..:  .....|||      :.|:..:|..|.|           ...
Zfish   648 EELAHVHVPQLYDCMQALGVIS--TISLSWFLTLFLSVMPFESAVVVVDCF-----------FYE 699

  Fly  1093 GHFVLF-LALALLET--------------------YRDIILSNSMDFTDV---IKFFNEMAERHN 1133
            |..|:| |||::|:.                    |.|.:.:.......:   .....:..|.|.
Zfish   700 GIKVIFQLALSVLDANIHQLLGCKDDGEAMTILGRYLDSVTNKDSTLPPIPHLHSLLTDNGEPHP 764

  Fly  1134 AQSVLQLARS 1143
            ...:.:|.||
Zfish   765 EVDIFKLVRS 774

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tbc	NP_001285494.1	RUN	45..218	CDD:280855
		PH_RUTBC	292..466	CDD:275431
		TBC	923..1087	CDD:214540	40/178 (22%)
tbc1d9	XP_692034.2	PH-GRAM1_TCB1D9_TCB1D9B	154..252	CDD:275420	19/100 (19%)
		PH-GRAM2_TCB1D9_TCB1D9B	301..396	CDD:270161	18/104 (17%)
		TBC	510..720	CDD:214540	48/226 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900