Protein Alignment tbc and tbc1d2

DIOPT Version :9

• Sequence 1: NP_001285494.1
• Gene: tbc / 318059
• FlyBaseID: FBgn0052506
• Length: 1155
• Species: Drosophila melanogaster
• Sequence 2: XP_689604.6
• Gene: tbc1d2 / 561110
• ZFINID: ZDB-GENE-140106-100
• Length: 926
• Species: Danio rerio
• Alignment Length: 844
• Identity: 140/844 - (16%)
• Similarity: 275/844 - (32%)
• Gaps: 294/844 - (34%)

  Fly   463 VSKSRHEEFAATHSILDFVRSTPRRAQLSSCSTTGSSDCSNKSLSIDQFP--------------- 512
            :.:::..:..|.|      :||||...|::.||..:::|....|.:.:.|
Zfish   147 LKRAQFRDQQAEH------QSTPRPDSLTTESTPPANNCPANFLPMVKTPSGLVGEEAASLPAPG 205

  Fly   513 --------MESPLILQQ------QQQQQQQLLQ---------------AQSTSIEMVCSTMRRQI 548
                    ::.|||..|      :.:|.|::.|               :..||..:|.:|...|.
Zfish   206 LNNPLNMSIKHPLIELQNTMHSFRNRQSQEIRQSVFHIDDPGDTQKTTSPKTSTLVVPATTSYQA 270

  Fly   549 ISRAFYGWLAYCR--HLSTVRTHLSGLVHGRITPEMKADEEGLTKERWQLLNVNGVLENATEFYR 611
            .....   .|.|.  |.:.:.|         |:...|:.     |||.:.|::....:...|...
Zfish   271 PESPV---KAKCEDPHQNNIST---------ISQNRKSG-----KERSRFLDLKDTSQLQHEKLS 318

  Fly   612 LVYFGGVQPELRQEVWPYLLGHYAFGSTTEDRKKQDETCKHYYETTMSEWLAVDAIVQQREKEKT 676
            |......|.||      .||.|    ...|..:.:..||        :::||.:.     |:|:
Zfish   319 LAEEVKAQKEL------VLLLH----KVLEAAQLEKRTC--------AQFLAAEG-----EQER- 359

  Fly   677 ARAVAKLSSGSNSGNDRTVRAADLEAGGDLENE-VFEDISDISDPGDLEFDEQQQQQQQQAECAV 740
               :..|..|.....:..|:...|:.    ||| :..|::        :.||...:.|...:..:
Zfish   360 ---MELLRHGERRAAELRVQLEALQQ----ENENLRRDLT--------QRDEHVAELQNSIQLLL 409

  Fly   741 SGNHLTVKPIPRAMKTSTDSGHVDESFNELDEPDEEDNKQKQQQDEKISESESKLPDYRKLEEQI 805
            ..|....:.|.:..:..|..|...:..|.|   :.|..:|...::|::.:.   |..|....:.:
Zfish   410 QKNQTKQEVILKLSEKLTTCGEDQQYTNGL---ESETFRQMTMENEQLKDD---LKAYNIQNQYL 468

  Fly   806 NQEPSCSASTASSYETVGPGEVHQ-----RPNSDTRS--VLSPEYLSADDLQLP----------D 853
            |                  .|::|     |.:|:...  ::....|.|::.|:.          .
Zfish   469 N------------------SEIYQLTMLWRKSSEREKSLIVKCAVLEANNCQMESRYLGILQKLQ 515

  Fly   854 DEDAVRPPPPPAAAAVIITKASVDITNWERSPKAAEGDQMSPLEEQAGESGGAGVNMD------- 911
            :...:.|....|...::......|:.|         ..:::|:.:.  :..|..:.:|
Zfish   516 ESQELNPEQREAVNKMLKDAVQADLNN---------AIKLNPISDY--DEYGFRIAVDYKVEDLK 569

  Fly   912 ------ALQ--------------------------QPKSACASPASSNGGVYSS----------- 933
                  ||:                          :|:....|.|...|.:.:.
Zfish   570 LLAKIQALEFRSQNLLNQEECDGPLLARCAQLLFGRPEGELTSSAEMKGLLRTGLPHEYRVRVWR 634

  Fly   934 -------------------ELLEQFGLNLHRIEKDVQRCDRNYWYFANEN--------LDKLRNV 971
                               ||.|:...:.|.:.:.:| .|.:....:|::        :.||..|
Zfish   635 FMIQTRTKSLRERHPDRYHELCEKSRSSPHLVPRQIQ-LDLDRTLTSNKHFSPPTSPLIQKLERV 698

  Fly   972 ISTYVWEHLDVGYMQGMCDLVAPLLVIFDDESLSYSCFCKLMER--------------------- 1015
            :..:.|.:..:||:||:..|.|..|::..:|:.::.|...::|.
Zfish   699 LQAFSWHNPTIGYVQGLNRLAAIALLVLQEEADAFWCLVVIVEHIMPPNYFTKDLVGCQADQRVL 763

  Fly  1016 ---MIENFPSGGAMDMHFANMRSLIQILDSEMYDLMDSNGDYTHFYFCYRWFLLDFKRELVYDDV 1077
               |:|..|   .:..|...::..|.::..|                   |||:.|...|....:
Zfish   764 KDLMLEKLP---RLTAHLEALKVDISLITVE-------------------WFLVLFVESLPTRIL 806

  Fly  1078 FATWEVIWAAKHIASGHFVLF-LALALLETYRDIIL--SNSMDFTDVIKFF-NEMAERHNAQSV 1137
            |..|:.:     :..|..|:| .||||.:...:.||  .:|::....::.| |.:|:.....|:
Zfish   807 FKVWDAL-----LYEGSKVIFRYALALFKYREEAILKIQDSVEMYQYLRIFPNTIADGRKLTSI 865

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tbc	NP_001285494.1	RUN	45..218	CDD:280855
		PH_RUTBC	292..466	CDD:275431	0/2 (0%)
		TBC	923..1087	CDD:214540	36/225 (16%)
tbc1d2	XP_689604.6	PH	56..146	CDD:278594
		PH_TBC1D2A	57..153	CDD:269966	0/5 (0%)
		TBC	621..837	CDD:214540	41/243 (17%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900