DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tbc and tbc1d14

DIOPT Version :9

Sequence 1:	NP_001285494.1	Gene:	tbc / 318059	FlyBaseID:	FBgn0052506	Length:	1155	Species:	Drosophila melanogaster
Sequence 2:	XP_005166496.1	Gene:	tbc1d14 / 557744	ZFINID:	ZDB-GENE-030131-6136	Length:	711	Species:	Danio rerio

Alignment Length:	794	Identity:	161/794 - (20%)
Similarity:	256/794 - (32%)	Gaps:	253/794 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   489 QLSSCSTTGSSDCSNKSLSIDQFPMESPLILQQQQQQQQQLLQAQSTSIEMVCSTMRRQIISRAF 553
            ::||.|.:..:.|    |.|...|      |.|...........|..::.:.|         ::|
Zfish    22 EVSSFSNSSLNQC----LPISSKP------LTQNNVDHHVPSDTQPPNVSLSC---------KSF 67

  Fly   554 YGWLAYCRH-LSTVRTHLSGL----------VHGRIT-PEMKA----DEEGLTKERWQLLNV--- 599
            ..:...|.. .|::.:..||:          :|.|:| .|:..    |:...|      ||:
Zfish    68 TSFNGTCEEDRSSLGSQDSGIPTLEINPPEHIHARVTIAELVVPPPHDDNPAT------LNLDIS 126

  Fly   600 NGVLENATEFYRLVYFGGVQPELRQEVWPYLLGHY-------AFGSTTEDRKKQDETCK-HYYET 656
            :|.|..::.|.|..:              .|:.||       |.|..|.:|......|. ....|
Zfish   127 DGSLLKSSTFPRCDF--------------DLVRHYGPSGLSSAAGKGTLNRSDDISVCSVSSLST 177

  Fly   657 TMSEWLAVDAIVQQREKEKTARAVAKLSSGSNSGNDRTVRAADLEAGGDLENEVFEDI-----SD 716
            ..|..|:|                      ||......:..::..|....||   ||:     |.
Zfish   178 EFSTTLSV----------------------SNEDFLDFMVTSESSAVVTFEN---EDVLHRFDSS 217

  Fly   717 ISDPGDLEFDEQQQQQQQQAECAVSGNHLTVKPIPRAMKTSTDSGHVDESFNE-LDEPDEEDNKQ 780
            :|.|.||.......|:|   ...|||.|   :..|:.:      |.:...||. |.....:|...
Zfish   218 LSAPIDLHGKLSSPQRQ---PVGVSGAH---EARPKRL------GPLASFFNRGLFAKRMKDTGA 270

  Fly   781 KQQQDE-------KISESESKLPDYRKLEEQINQEPSCSASTASSYETVGPGEVHQRPNSDTRSV 838
            .:.|.|       |:...:....|.|||:::..:....::::.|             |..:.|..
Zfish   271 LEGQREPGWKLFGKVPHKDLPTKDSRKLQKEYERRSGHTSNSTS-------------PKKNVRKN 322

  Fly   839 LSPEYLSADDLQLPDDEDAVRPPPPPAAA--------AVIITKASVDITNWERSPKAAEGDQMSP 895
            |..|.||...|.| ::..|..|..|...|        .::......::.:.::..|..|  ....
Zfish   323 LDFEPLSTTALIL-ENRPANLPAKPEEEAQKHRQQYEEMVAQAKKRELKDAQKRKKQLE--DRCK 384

  Fly   896 LEEQAGESGGAGVNMDALQQPKSACAS-----------PASSNGGVYS----SEL---------- 935
            |||..| :.....:.:.|...:|.|:|           |.|..|.|:|    :||
Zfish   385 LEESIG-NAALTWSQEILPNWQSMCSSKRVRDLWWQGLPPSVRGKVWSLAIGNELNITDELYDIC 448

  Fly   936 ---------------------LEQFGL-------NLHRIEKDVQRCDRNYWYF--ANENLDKLRN 970
                                 .|..||       :|..|:.|:.|...|...|  .....|.|.:
Zfish   449 LARAKEKWNAFVAPTAAVETESEDAGLSHADREASLELIKLDISRTFPNLCIFQKGGPYHDVLHS 513

  Fly   971 VISTYVWEHLDVGYMQGMCDLVAPLLVIFD-----------------------DESLSYSCFCKL 1012
            ::..|.....||||:|||..:.|.|::..|                       |.||..:.|...
Zfish   514 ILGAYTCYRPDVGYVQGMSFIAAVLILNLDTADAFIAFANLLNKPCQMAFYRVDHSLMLTYFAAF 578

  Fly  1013 MERMIENFPSGGAMDMHFANMRSLIQILDSEMYDLMDSNGDYTHFYFCYRWFLLDFKRELVYDDV 1077
            .....||.|.   :..||.|..     |.|::| |:|             |....:.:.|..|..
Zfish   579 EVFFEENLPK---LFAHFKNNN-----LSSDIY-LID-------------WIFTLYSKSLPLDIA 621

  Fly  1078 FATWEVIWAAKHIASGHFVLF-LALALLETYRDIILSNSMDFTDVIKFFNEMAERHNAQSVLQLA 1141
            ...|:|.     ...|...|| .||.:|..|.||:  ..|||..:.:|...:.:..:|:.:.
Zfish   622 CRVWDVF-----CRDGEEFLFRTALGILRLYEDIL--THMDFIHIAQFLTRLPDYISAEEIF--- 676

  Fly  1142 RSLVLQLQMIIENK 1155
             |.:..:.|..:||
Zfish   677 -SSITTINMNSKNK 689

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tbc	NP_001285494.1	RUN	45..218	CDD:280855
		PH_RUTBC	292..466	CDD:275431
		TBC	923..1087	CDD:214540	49/230 (21%)
tbc1d14	XP_005166496.1	COG5210	293..656	CDD:227535	86/408 (21%)
tbc1d14	XP_005166496.1	RabGAP-TBC	485..651	CDD:278964	46/192 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900