Protein Alignment tbc and tbc1d25

DIOPT Version :10

• Sequence 1: NP_608395.6
• Gene: tbc / 318059
• FlyBaseID: FBgn0052506
• Length: 1155
• Species: Drosophila melanogaster
• Sequence 2: NP_001121708.1
• Gene: tbc1d25 / 556338
• ZFINID: ZDB-GENE-041111-25
• Length: 863
• Species: Danio rerio
• Alignment Length: 324
• Identity: 95/324 - (29%)
• Similarity: 141/324 - (43%)
• Gaps: 58/324 - (17%)

  Fly   782 QQQDEKISESESKLPDYRKLEEQINQEPSCSASTAS-SY-ETVGP-------GEVHQRPNSDTRS 837
            |.|.||.|.:.:.||..:.|..|:.:..|......| || |.|.|       .|.|...||..:
Zfish   123 QLQGEKRSLASAALPFTQSLLSQVGRTLSRVQQALSWSYGEEVKPFKPPLSDAEFHNYLNSQGQ- 186

  Fly   838 VLSPEYLSADDLQLPDDEDAVRPPPPPAAAAVIITKASVDITNWER----SPKAAEGDQMSPLEE 898
            :..||     :|:|......|...........::......:|..||    ..|..|.||:
Zfish   187 LSRPE-----ELRLRIYHGGVESSLRKVVWRYLLNVYPDGLTGQERMDYMKRKTREYDQL----- 241

  Fly   899 QAGESGGAGVNMDALQQPKSACASPASSNGGVYSSELLEQFGLNLHRIEKDVQRCDRNYWYFA-- 961
                              ||...:..       |||.||....|   :.|||.|.||.:.|:|
Zfish   242 ------------------KSEWTARV-------SSEELEFIRGN---VLKDVLRTDRAHPYYAGS 278

  Fly   962 --NENLDKLRNVISTYVWEHLDVGYMQGMCDLVAPLLVIFDDESLSYSCFCKLMERMIENF-PSG 1023
              :.:|..|.::::|:...|..|.|.|||.|:.:|:|.:.|:|:.::.|||.:|:|:..|| |.|
Zfish   279 EDSPHLTALTDLLTTFAITHPQVSYCQGMSDIASPILAVMDNEAHAFICFCGIMKRLEGNFRPDG 343

  Fly  1024 GAMDMHFANMRSLIQILDSEMYDLMDSNGDYTHFYFCYRWFLLDFKRELVYDDVFATWEVIWAA 1087
            ..|.:.|.:::.|:|..|.|.|..:.|.| ....:|||||.||:.|||..:||.....||.|::
Zfish   344 QLMSIKFQHLKLLLQYSDPEFYSYLVSKG-ADDLFFCYRWLLLELKREFAFDDALRMLEVTWSS 406

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tbc	NP_608395.6	RUN_SGSM1_like	21..214	CDD:439049
		PH_RUTBC	292..466	CDD:275431
		TBC	923..1087	CDD:214540	61/168 (36%)
tbc1d25	NP_001121708.1	TBC	198..420	CDD:214540	71/243 (29%)