DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tbc and rabgap1l

DIOPT Version :9

Sequence 1:	NP_001285494.1	Gene:	tbc / 318059	FlyBaseID:	FBgn0052506	Length:	1155	Species:	Drosophila melanogaster
Sequence 2:	XP_021325262.1	Gene:	rabgap1l / 555272	ZFINID:	ZDB-GENE-050208-389	Length:	1069	Species:	Danio rerio

Alignment Length:	1014	Identity:	199/1014 - (19%)
Similarity:	339/1014 - (33%)	Gaps:	317/1014 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   227 ADEL--------VQRHRISSCRRSSSTCSRPAIINFKRSLNTSSDEAG-----TGSFKSIASASV 278
            |||:        .:..|.|:.|:...:.|||:    .||:....|::.     :||.:|:::.:
Zfish    10 ADEVCGCLCVYCARAARRSADRQQGCSSSRPS----GRSVQAIMDDSSSLGRVSGSTESVSTVT- 69

  Fly   279 AKDYVESLHQNAKATLLYGKNNVQVLPKDVAEPMPGYLSLHQHIQTLTIKWTPNQLMNGYTEAEE 343
            ::::|                   ::|....    |..|..:....|.:.|      ||..:.|.
Zfish    70 SEEFV-------------------LVPPSAG----GSPSSSEGRPRLKMSW------NGSEQLER 105

  Fly   344 A--EDIDKDAFWAYALNINVDEIVYVHCHQSRGEDSGGTVILVGQDGVQRPPIHFPEGGHMQQFL 406
            |  |.:|..|..|.|                 .::.|.|.|        ||| ......| :...
Zfish   106 AMEEVLDDVADGAGA-----------------EQEKGCTQI--------RPP-SLDTAPH-ESSA 143

  Fly   407 SCLETGLLPHGQLDPPLWSQRGIGKMFL---W---PRS---MRRRILPSVMESVDETPI------ 456
            :.||:..:|..:      |.:.....:|   |   |||   .::.:.....||....|:
Zfish   144 ALLESPTVPEEE------SVQFSKLSYLGCTWVKAPRSETEAQKAMATLRAESAIPIPVILHVPN 202

  Fly   457 --DYVFRIVSKSRHEEFAA--THSILDFVRSTPRRAQLSSCSTTGSSDC---SNKSLSIDQFPME 514
              |...|||.::...|.|:  .:.:|...|         .|..:..|||   :....|.:.|.:.
Zfish   203 GSDGCVRIVDQASGTEIASFPIYKVLFCAR---------GCEGSVESDCFSFTESYRSSEDFQIH 258

  Fly   515 SPLILQQQQQQQQQLLQAQSTSIEMVCSTMRRQIISRAFYGWLAYCRHLSTVRTHLSGLVHGRIT 579
                                     |.|...::.:||..|.:....:..:...|.:..      :
Zfish   259 -------------------------VFSCHIKEAVSRILYSFSTAFKRSAKAATEMQD------S 292

  Fly   580 P-EMKADEEGLTKERWQLLNVNGVLENATEFYRLVYFGGVQPELRQEVWPYLLGHYAFGSTTEDR 643
            | .:..|.:                         |:...|..|:|::.     |...|....:||
Zfish   293 PLPLSPDSD-------------------------VFTFSVSLEVREDD-----GKGNFSPVPKDR 327

  Fly   644 KKQDETCKHYYETTMSEWLAVDAIVQQREKEKTA--RAVAKLSSGSNSGNDRTVRAADLEAGG-- 704
            .      |:|::........|..:|||...::..  |....|.|......:..:...|:|:.|
Zfish   328 D------KYYFKLRQGVQKKVSVVVQQLNNKELVIERCFGMLLSPGQKVRNSDMHLLDMESMGKN 386

  Fly   705 -DLENEVFEDISDISDPGDLEFDEQQQQQQQQAECAVSGNHLTVKPIPRAMKTSTDSGHVDESFN 768
             |.:..|...|.:.:.|.....:|...:.:|.        ::||.              ||....
Zfish   387 ADGKAYVITGIWNPNTPAFQPLNEDTPKDKQV--------YMTVA--------------VDLVVT 429

  Fly   769 ELDEPDE---EDNKQKQQQDEKISESESKL---PDYRKLEEQINQEPSCSASTASS-----YETV 822
            |:.||..   |...:....:|:......|.   ..|.||::         .|...|     ||.|
Zfish   430 EVVEPVRFLMEALVRVYPANERFWYFSRKAFCETFYLKLKQ---------GSVKGSQDDMMYEVV 485

  Fly   823 GPGEVHQRPNSDTRSVLSPEYLSADDLQLPDDEDAVRPPPPPAAAAVIITKASVDITNWERSPKA 887
            .. |.|....|..|.          .||.|.:|:   .|...:.:.:                .:
Zfish   486 SL-EKHSECGSQARG----------RLQSPTEEE---EPEEDSDSEI----------------SS 520

  Fly   888 AEGDQMSPLEEQAGESGGAGVNM---DALQQPK--SACASPASSN----------GGVYSSE-LL 936
            ..||......|:..||.|..:|.   :.|.:||  ||...|....          .|.::.: ||
Zfish   521 GTGDVSKDCPEKILESWGGILNRWQGNLLTRPKGLSALVKPGIPEALRAEVWQLLSGCHNDQALL 585

  Fly   937 EQFGLNLHR-------IEKDVQRCDRNYWYF---ANENLDKLRNVISTYVWEHLDVGYMQGMCDL 991
            ||:.:.:.:       |.:|:.|....:.||   ..:..|.|..:...|.....::||.||...|
Zfish   586 EQYRILITKESAQEAVITRDIHRTFPAHDYFKDSGGDGQDSLYKICKAYSVYDEEIGYCQGQSFL 650

  Fly   992 VAPLLVIFDDESLSYSCFCKLMERMI---------ENFPSGGAMDMH--FANMRSLIQILDSEMY 1045
            .|.||:...:|    ..||.|::.|.         .||.     |:|  |..:..|:|.|..:::
Zfish   651 AAVLLLHMPEE----QAFCVLVKIMFNYGLRELYRNNFE-----DLHCKFYQLERLLQELLPDLW 706

  Fly  1046 DLMDSNGDYTHFYFCYRWFLLDFKRELVYDDVFATWEVIWAAKHIASGHFVLF-LALALLETYRD 1109
            ..........|.| ..:|||..|..:.....||...:::     :..|..::| :|||||:|.::
Zfish   707 SHFQELNLEAHMY-ASQWFLTLFTAKFPLCMVFHITDLL-----LCEGLNIIFNVALALLKTSKE 765

  Fly  1110 IILSNSMDFTDVIKFFN-EMAERHNAQSVLQLARSLVLQ 1147
            .:|  ..||...:|||. ::.:|:.|   .:.||.|:.|
Zfish   766 DLL--QADFEGALKFFRVQLPKRYRA---AENARRLMEQ 799

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tbc	NP_001285494.1	RUN	45..218	CDD:280855
		PH_RUTBC	292..466	CDD:275431	37/192 (19%)
		TBC	923..1087	CDD:214540	43/195 (22%)
rabgap1l	XP_021325262.1	PTB_Rab6GAP	157..285	CDD:269922	27/161 (17%)
		DUF3694	319..450	CDD:315198	29/158 (18%)
		RabGAP-TBC	565..768	CDD:306939	50/217 (23%)
		SMC_N	784..>1042	CDD:330553	6/19 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900