DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tbc and tbc1d17

DIOPT Version :9

Sequence 1:	NP_001285494.1	Gene:	tbc / 318059	FlyBaseID:	FBgn0052506	Length:	1155	Species:	Drosophila melanogaster
Sequence 2:	XP_005164004.1	Gene:	tbc1d17 / 554092	ZFINID:	ZDB-GENE-050522-79	Length:	639	Species:	Danio rerio

Alignment Length:	925	Identity:	177/925 - (19%)
Similarity:	281/925 - (30%)	Gaps:	431/925 - (46%)

- Green bases have known domain annotations that are detailed below.

  Fly   286 LHQNAKATLLYGKNNVQVLPKDVAEPMPGYLSLHQHIQTLTIKWTPNQLMNGYTEAEEAEDIDKD 350
            ||.|||      ::|     :|..  :||::.:.:......::|:|            .||..:
Zfish    19 LHTNAK------RSN-----QDTT--IPGFIRIVERDGEPALEWSP------------VEDDGR- 57

  Fly   351 AFWAYALNINVDEIVYVHCHQSRGE-----DSG-----GTVILVGQDGVQ-RPPIHFPEGGHMQQ 404
                     |...:.|.......||     |.|     ..:..|.||..| :||:.  |.||...
Zfish    58 ---------NAPAVFYTKKDGEGGEEETKFDPGYEPDWAVISTVKQDRRQEQPPVR--ETGHWSS 111

  Fly   405 F-LSCLETGLLPHGQLD----------------PPLWSQRGIGKMFLWPRSMRR--RILPSVMES 450
            | |...|...|...:..                |||...||..:..|  ::|:|  |:.||.|:.
Zfish   112 FSLPLSELYSLRRARFSLGRNFLVLTTRGGDPLPPLHFHRGGTRELL--KAMQRYIRLAPSPMDG 174

  Fly   451 ----------------------VDETPIDYVFRIVSKSRHEEFAATHSILDFVRSTPRRAQLSSC 493
                                  .|:|..|.|.|.:.......|.....:.:|.|...|..:
Zfish   175 RLFLAYPHDSGALSQSFDELHLFDDTSADLVSRFIQDPYATTFGGFSKVTNFFRGALRNPE---- 235

  Fly   494 STTGSSDCSNKSLSIDQFPMESPLILQQQQQQQQQLLQAQSTSIEMVCSTMRRQIISRAFYGWLA 558
                 |..:|:|.....||..:.                :....|::  |...::..|
Zfish   236 -----SPLNNRSPQDPHFPHSAD----------------EEPGFELI--TCGAELGPR------- 270

  Fly   559 YCRHLSTVRTHLSGLVHGRITPEMKADEEGLTKERW-QLLNVNGVLENATEFYRLVYFGGVQPEL 622
                                 ||:|   .|...:.| |.|:..|.:.:..:...||:.||:.|.|
Zfish   271 ---------------------PEVK---RGKPLDNWEQFLDPEGRVTDPQKVKELVFRGGIVPYL 311

  Fly   623 RQEVWPYLLGHYAFGSTTEDRK-----KQDETCKHYYETTMSEWLAVDAIVQQREKEKTARAVAK 682
            |:|||.:|||.|.:.|||::|:     |.||    |:...: :|.:|
Zfish   312 RKEVWKFLLGFYPWNSTTKEREDILMVKTDE----YFRMKV-QWKSV------------------ 353

  Fly   683 LSSGSNSGNDRTVRAADLEAGGDLENEVFEDISDISDPGDLEFDEQQQQQQQQAECAVSGNHLTV 747
                                                       .|:|:
Zfish   354 -------------------------------------------SEEQE----------------- 358

  Fly   748 KPIPRAMKTSTDSGHVDESFNELDEPDEEDNKQKQQQDEKISESESKLPDYRKLEEQINQEPSCS 812
                  |:.|...|                                    ||.|
Zfish   359 ------MRNSLFRG------------------------------------YRSL----------- 370

  Fly   813 ASTASSYETVGPGEVHQRPNSDTRSVLSPEYLSADDLQLPDDEDAVRPPPPPAAAAVIITKASVD 877

Zfish   371 ----------------------------------------------------------------- 370

  Fly   878 ITNWERSPKAAEGDQMSPLEEQAGESGGAGVNMDALQQPKSACASPASSNGGVYSSELLEQFGLN 942

Zfish   371 ----------------------------------------------------------------- 370

  Fly   943 LHRIEKDVQRCDR-NYWYFANEN--LDKLRNVISTYVWEHLDVGYMQGMCDLVAPLLVIFDDESL 1004
               ||:||.|.|| |.::..|||  |..|.:|:.||...:.|:||:|||.||::|||.:..:|..
Zfish   371 ---IERDVNRTDRHNSFFSGNENPGLTLLHDVLMTYCMYNFDLGYVQGMSDLLSPLLFVTQNEVE 432

  Fly  1005 SYSCFCKLMERMIENF-PSGGAMDMHFANMRSLIQILDSEMYDLMDSNGDYTHFYFCYRWFLLDF 1068
            |:.|....|:.:.:|| .|..||......:..|::.||.|:.|.:||. |.....||:||.|:.|
Zfish   433 SFWCLTGFMDLVHQNFEESQEAMKQQLLQLSLLLRALDPELCDYLDSQ-DSGSLCFCFRWLLIWF 496

  Fly  1069 KRELVYDDVFATWEVIWAAKHIASGHFVLFLALALLETYRDIILSNSMDFTDVIKFFNEMAERHN 1133
            |||..::|:.:.|||:|.  .:...:|.|.:|.::||:.::.::.::.||..::|..||:..:.:
Zfish   497 KREFSFEDILSLWEVLWT--RLPCENFHLLMACSILESQKEELIGSNHDFNSILKHINELTMKLD 559

  Fly  1134 AQSVLQLARSLVLQL 1148
            .||||..|.::.|||
Zfish   560 LQSVLCGAEAIYLQL 574

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tbc	NP_001285494.1	RUN	45..218	CDD:280855
		PH_RUTBC	292..466	CDD:275431	44/225 (20%)
		TBC	923..1087	CDD:214540	58/167 (35%)
tbc1d17	XP_005164004.1	DUF3548	5..211	CDD:192931	49/230 (21%)
tbc1d17	XP_005164004.1	TBC	303..538	CDD:214540	93/506 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810