DRSC/TRiP Functional Genomics Resources

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Protein Alignment tbc and TBC1D2

DIOPT Version :10

Sequence 1:NP_608395.6 Gene:tbc / 318059 FlyBaseID:FBgn0052506 Length:1155 Species:Drosophila melanogaster
Sequence 2:NP_001254500.1 Gene:TBC1D2 / 55357 HGNCID:18026 Length:928 Species:Homo sapiens


Alignment Length:686 Identity:123/686 - (17%)
Similarity:235/686 - (34%) Gaps:218/686 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   587 EGLTKER----------WQLLNVNGVLENATEFYRLVY--FGGVQPELRQEVWPYLLGHYAFGST 639
            ||:|:.|          .|:|.:...|::..|..::::  ....|.|.|        ...|:.:.
Human   296 EGITRNRTAQEKVAALEQQVLMLTKELKSQKELVKILHKALEAAQQEKR--------ASSAYLAA 352

  Fly   640 TEDRKKQDETCKHYYETTMSEWLAVDAIVQQREKEKTARAVAKLSSGSNSGNDRTVRAADLEAGG 704
            .|| |.:.|..:|...........|:|:.|:||.                    ....|.|.   
Human   353 AED-KDRLELVRHKVRQIAELGRRVEALEQERES--------------------LAHTASLR--- 393

  Fly   705 DLENEVFEDISDISDPGDLEFDEQQQQQQQQAECAVSGNHLTVKPIPR-AMKTSTDSGHVDESFN 768
                                 ::|.|:.||..:..:..||...:.|.: :.|.:.|..|      
Human   394 ---------------------EQQVQELQQHVQLLMDKNHAKQQVICKLSEKVTQDFTH------ 431

  Fly   769 ELDEPDEED------NKQKQQQDEKISESESKLPDYRKLEEQINQEPSCSASTASSYETVGPGEV 827
               .||:..      |:....|..||...:..:..||.....:|                  .|:
Human   432 ---PPDQSPLRPDAANRDFLSQQGKIEHLKDDMEAYRTQNCFLN------------------SEI 475

  Fly   828 HQ-----RPNSDTRSVLSPE--YLSADDLQLPD--------------DEDAVRPPPPPAAAAVII 871
            ||     |..::....|..:  ||.|.:.|:..              ||        .:..:.::
Human   476 HQVTKIWRKVAEKEKALLTKCAYLQARNCQVESKYLAGLRRLQEALGDE--------ASECSELL 532

  Fly   872 TKASVDITNWERSPKAAEGDQMSPLEE-----------------------QAGESGGAG-VNMDA 912
            .:...:...||....:::..::||:.:                       ||.||.... :.::|
Human   533 RQLVQEALQWEAGEASSDSIELSPISKYDEYGFLTVPDYEVEDLKLLAKIQALESRSHHLLGLEA 597

  Fly   913 LQQP-KSACAS-----PASS------------------------------NGGVYSSELLEQFGL 941
            :.:| :...|:     |::.                              ..|.| .|||.:...
Human   598 VDRPLRERWAALGDLVPSAELKQLLRAGVPREHRPRVWRWLVHLRVQHLHTPGCY-QELLSRGQA 661

  Fly   942 NLH----RIEKDVQRCDRNYWYF---ANENLDKLRNVISTYVWEHLDVGYMQGMCDLVAPLLVIF 999
            ..|    :||.|:.|...|..:|   .:...||||.|:..:.|::..:||.||:..|.|..|::.
Human   662 REHPAARQIELDLNRTFPNNKHFTCPTSSFPDKLRRVLLAFSWQNPTIGYCQGLNRLAAIALLVL 726

  Fly  1000 DDESLSYSCFCKLMERMIENFPSGGAMDMHFANMRSLIQILDSEMYDLMDSNGDYTHF---YFCY 1061
            ::|..::.|...::|.::........:.....:.|.|..:|..::..||...|.: |.   ...:
Human   727 EEEESAFWCLVAIVETIMPADYYCNTLTASQVDQRVLQDLLSEKLPRLMAHLGQH-HVDLSLVTF 790

  Fly  1062 RWFLLDFKRELVYDDVFATWEVIWAAKHIASGHFVLF-LALALLE-TYRDII-LSNSMDFTDVIK 1123
            .|||:.|...|:.:.:...|:..     :..|..|:| .|||:.: ..::|: |.|.::....::
Human   791 NWFLVVFADSLISNILLRVWDAF-----LYEGTKVVFRYALAIFKYNEKEILRLQNGLEIYQYLR 850

  Fly  1124 FFNEMAERHNAQSVLQLA--------RSLVLQLQMI 1151
            ||.:...  |::.::.:|        ...:.||:|:
Human   851 FFTKTIS--NSRKLMNIAFNDMNPFRMKQLRQLRMV 884

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
tbcNP_608395.6 RUN_SGSM1_like 21..214 CDD:439049
PH_RUTBC 292..466 CDD:275431
TBC 923..1087 CDD:214540 42/203 (21%)
TBC1D2NP_001254500.1 SMC_prok_B <276..480 CDD:274008 46/263 (17%)
Interaction with RAC1. /evidence=ECO:0000269|PubMed:20116244 295..433 34/198 (17%)
TBC 625..837 CDD:214540 47/218 (22%)
Interaction with CADH1 1..169
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..39
PH_TBC1D2A 47..147 CDD:269966
Atrophin-1 <183..>292 CDD:460830
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 225..275
Blue background indicates that the domain is not in the aligned region.

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