DRSC/TRiP Functional Genomics Resources

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Protein Alignment tbc and TBC1D2

DIOPT Version :9

Sequence 1:NP_001285494.1 Gene:tbc / 318059 FlyBaseID:FBgn0052506 Length:1155 Species:Drosophila melanogaster
Sequence 2:NP_001254500.1 Gene:TBC1D2 / 55357 HGNCID:18026 Length:928 Species:Homo sapiens


Alignment Length:686 Identity:123/686 - (17%)
Similarity:235/686 - (34%) Gaps:218/686 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   587 EGLTKER----------WQLLNVNGVLENATEFYRLVY--FGGVQPELRQEVWPYLLGHYAFGST 639
            ||:|:.|          .|:|.:...|::..|..::::  ....|.|.|        ...|:.:.
Human   296 EGITRNRTAQEKVAALEQQVLMLTKELKSQKELVKILHKALEAAQQEKR--------ASSAYLAA 352

  Fly   640 TEDRKKQDETCKHYYETTMSEWLAVDAIVQQREKEKTARAVAKLSSGSNSGNDRTVRAADLEAGG 704
            .|| |.:.|..:|...........|:|:.|:||.                    ....|.|.   
Human   353 AED-KDRLELVRHKVRQIAELGRRVEALEQERES--------------------LAHTASLR--- 393

  Fly   705 DLENEVFEDISDISDPGDLEFDEQQQQQQQQAECAVSGNHLTVKPIPR-AMKTSTDSGHVDESFN 768
                                 ::|.|:.||..:..:..||...:.|.: :.|.:.|..|      
Human   394 ---------------------EQQVQELQQHVQLLMDKNHAKQQVICKLSEKVTQDFTH------ 431

  Fly   769 ELDEPDEED------NKQKQQQDEKISESESKLPDYRKLEEQINQEPSCSASTASSYETVGPGEV 827
               .||:..      |:....|..||...:..:..||.....:|                  .|:
Human   432 ---PPDQSPLRPDAANRDFLSQQGKIEHLKDDMEAYRTQNCFLN------------------SEI 475

  Fly   828 HQ-----RPNSDTRSVLSPE--YLSADDLQLPD--------------DEDAVRPPPPPAAAAVII 871
            ||     |..::....|..:  ||.|.:.|:..              ||        .:..:.::
Human   476 HQVTKIWRKVAEKEKALLTKCAYLQARNCQVESKYLAGLRRLQEALGDE--------ASECSELL 532

  Fly   872 TKASVDITNWERSPKAAEGDQMSPLEE-----------------------QAGESGGAG-VNMDA 912
            .:...:...||....:::..::||:.:                       ||.||.... :.::|
Human   533 RQLVQEALQWEAGEASSDSIELSPISKYDEYGFLTVPDYEVEDLKLLAKIQALESRSHHLLGLEA 597

  Fly   913 LQQP-KSACAS-----PASS------------------------------NGGVYSSELLEQFGL 941
            :.:| :...|:     |::.                              ..|.| .|||.:...
Human   598 VDRPLRERWAALGDLVPSAELKQLLRAGVPREHRPRVWRWLVHLRVQHLHTPGCY-QELLSRGQA 661

  Fly   942 NLH----RIEKDVQRCDRNYWYF---ANENLDKLRNVISTYVWEHLDVGYMQGMCDLVAPLLVIF 999
            ..|    :||.|:.|...|..:|   .:...||||.|:..:.|::..:||.||:..|.|..|::.
Human   662 REHPAARQIELDLNRTFPNNKHFTCPTSSFPDKLRRVLLAFSWQNPTIGYCQGLNRLAAIALLVL 726

  Fly  1000 DDESLSYSCFCKLMERMIENFPSGGAMDMHFANMRSLIQILDSEMYDLMDSNGDYTHF---YFCY 1061
            ::|..::.|...::|.::........:.....:.|.|..:|..::..||...|.: |.   ...:
Human   727 EEEESAFWCLVAIVETIMPADYYCNTLTASQVDQRVLQDLLSEKLPRLMAHLGQH-HVDLSLVTF 790

  Fly  1062 RWFLLDFKRELVYDDVFATWEVIWAAKHIASGHFVLF-LALALLE-TYRDII-LSNSMDFTDVIK 1123
            .|||:.|...|:.:.:...|:..     :..|..|:| .|||:.: ..::|: |.|.::....::
Human   791 NWFLVVFADSLISNILLRVWDAF-----LYEGTKVVFRYALAIFKYNEKEILRLQNGLEIYQYLR 850

  Fly  1124 FFNEMAERHNAQSVLQLA--------RSLVLQLQMI 1151
            ||.:...  |::.::.:|        ...:.||:|:
Human   851 FFTKTIS--NSRKLMNIAFNDMNPFRMKQLRQLRMV 884

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
tbcNP_001285494.1 RUN 45..218 CDD:280855
PH_RUTBC 292..466 CDD:275431
TBC 923..1087 CDD:214540 42/203 (21%)
TBC1D2NP_001254500.1 Interaction with CADH1 1..169
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..39
PH_TBC1D2A 47..147 CDD:269966
PH 47..139 CDD:278594
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 225..275
Interaction with RAC1. /evidence=ECO:0000269|PubMed:20116244 295..433 34/198 (17%)
TBC 625..837 CDD:214540 47/218 (22%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5210
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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