DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tbc and rabgap1l

DIOPT Version :9

Sequence 1:	NP_001285494.1	Gene:	tbc / 318059	FlyBaseID:	FBgn0052506	Length:	1155	Species:	Drosophila melanogaster
Sequence 2:	NP_001361730.1	Gene:	rabgap1l / 550007	XenbaseID:	XB-GENE-483580	Length:	1056	Species:	Xenopus tropicalis

Alignment Length:	842	Identity:	172/842 - (20%)
Similarity:	283/842 - (33%)	Gaps:	265/842 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   460 FRIVSKSRHEEFAATHSILDFVRSTPRRAQLSSCST-------TGS--SDCSNKSLSI------- 508
            |:|:|....:...|...||.....|.....|....|       |.|  ||...|::.:
Frog    38 FKIMSNGDEQLEKAMEEILRDSEKTQNSNMLKETITEELSTFPTASHFSDTGTKNVPLTLILDPK 102

  Fly   509 -DQFPMESPLILQQQQQQQQQLLQAQSTSIEMVC-------STMRRQIIS-RAFYGWLAYCRHLS 564
             .:.|::|..:|....::       :|.|...:|       |..|.:|.: ||.....|.|....
Frog   103 STELPVQSTTVLSHPPEE-------ESVSFHKLCYLGCMKVSAPRNEIEALRAMASMKAQCIAPI 160

  Fly   565 TVRTHLSGLVHGRI----------------------------TPEMKA---DEEGLTKERWQLLN 598
            ||..::..:..|.:                            |.|...   .|..|..|.:|:..
Frog   161 TVTLYVPNIPEGSVRIIDQTNKSEIASFPIYKVLFCVRGRDGTSECDCFAFTERDLGTEEFQIHV 225

  Fly   599 VNGVLENATEFYRLVYFGGVQPELRQ--------------EVWPYLL----------GHYAFGST 639
            .:..::.|.......:|...:...||              :|:.:::          |:  |...
Frog   226 FSCEIKEAVSRILYSFFTAFKRSSRQVSDVKDSALPTPDSDVFTFMVSLEVKEDDSKGN--FSPV 288

  Fly   640 TEDRKKQDETCKHYYETTMSEWLAVDAIVQQREKE-KTARAVAKLSSGSNSGNDRTVRAADLEAG 703
            .:||.|.....|...|..:     |..|.|...|| ...|....|.|...:..:..:...|:|:.
Frog   289 PKDRDKLFFKLKQGIEKKV-----VVTIQQVSNKELLVERCFGMLLSPGRNVKNSDMHLLDMESM 348

  Fly   704 GDLENEVFEDISDISDPGDLEFDEQQQQQQQQAECAVSGNHLTVKPIPRAMKTSTDSGHVDESFN 768
            |...:.....|:.|.:|....|....::..:....     ::||.              ||....
Frog   349 GKSSDGKAYVITGIWNPNIQAFQALNEETPKDKRV-----YMTVA--------------VDMVVT 394

  Fly   769 ELDEPDE---EDNKQKQQQDEKI-SESESKLPD--YRKLEEQINQEPSCSAS-TASSYETVG--- 823
            |:.||..   |...:....:|:. ..|.....|  |.||      :||.:.. |.|.||.|.
Frog   395 EVVEPVRFLLETVVRVYPTNERFWYFSRKAFTDTFYLKL------KPSGNIGVTDSMYEVVSLQR 453

  Fly   824 PGEVHQRPNSDTRSVLSPEYLSADDLQLPDDEDAVRPPPPPAAAAVIITKASVDITNWERSPKAA 888
            ..|:.:.|.|.         |||.:|..|.:||
Frog   454 QSEIEEAPTSP---------LSASNLSSPQEED-------------------------------- 477

  Fly   889 EGDQMSPLEEQAGE--SGGAGVNMDALQQ-------------------PKSACA-----SPASSN 927
                 .|.||...|  ||...|:.|..:|                   ||...:     .|.:..
Frog   478 -----DPEEESDTELWSGTGDVSKDCPEQILDCWGQLLVKWHSNLSVKPKGLSSLVKRGIPEALR 537

  Fly   928 GGVY--------SSELLEQFGLNLHR-------IEKDVQRCDRNYWYFAN------ENLDKLRNV 971
            ..|:        :.|:|:::.:.:.:       |.:|:.|....:.||.|      |:|.|:..|
Frog   538 AEVWQLLAGCHENQEMLDKYKMLVVKDSAQDSVIRRDIHRTFPAHDYFKNTEGDGQESLYKMCKV 602

  Fly   972 ISTYVWEHLD--VGYMQGMCDLVAPLLVIFDDESLSYSCFCKLMERMIE----NFPSGGAMDMHF 1030
            .|.|     |  :||.|||..|.|.||:...:|    ..||.|::.|.:    |.......|:|
Frog   603 YSLY-----DEVIGYCQGMSFLAAVLLLHMPEE----QAFCVLVKIMYDYQFRNLYQNNFEDLH- 657

  Fly  1031 ANMRSLIQILDSEMYDLMDSNGDYTHF--------YFCYRWFLLDFKRELVYDDVFATWEVIWAA 1087
            .....|.::|..::.||      |:||        .:..:|||..|..:.....||...:::
Frog   658 CKFYQLERLLQEQLPDL------YSHFVALNLEAHMYASQWFLSLFTAKFPLCMVFHIMDLL--- 713

  Fly  1088 KHIASGHFVLF-LALALLETYRDIILSNSMDFTDVIKFFN-EMAERHNAQSVLQLARSLVLQ 1147
              ::.|..::| :|||||:|.::.:|  ..||...:|||. ::.:|:.|:   :.||.|:.|
Frog   714 --LSEGLSIIFHVALALLKTSKEDLL--QADFEGALKFFRVQLPKRYRAE---ENARRLMEQ 768

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tbc	NP_001285494.1	RUN	45..218	CDD:280855
		PH_RUTBC	292..466	CDD:275431	3/5 (60%)
		TBC	923..1087	CDD:214540	47/198 (24%)
rabgap1l	NP_001361730.1	PTB_Rab6GAP	123..251	CDD:269922	20/127 (16%)
		DUF3694	284..415	CDD:372133	29/156 (19%)
		TBC	528..737	CDD:214540	55/229 (24%)
		Smc	753..>1011	CDD:224117	6/19 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910