Protein Alignment tbc and TBC1D8B

DIOPT Version :10

• Sequence 1: NP_608395.6
• Gene: tbc / 318059
• FlyBaseID: FBgn0052506
• Length: 1155
• Species: Drosophila melanogaster
• Sequence 2: NP_060222.2
• Gene: TBC1D8B / 54885
• HGNCID: 24715
• Length: 1120
• Species: Homo sapiens
• Alignment Length: 753
• Identity: 143/753 - (18%)
• Similarity: 244/753 - (32%)
• Gaps: 240/753 - (31%)

  Fly   518 ILQQQQQQQQQLLQAQSTSIEMVCSTMRRQIISRAFYGWLA--YCRHLST------VRTHLSGLV 574
            ||.|....|..|        .:.|...|.:|...  :.||.  ..:.||.      :...:.|.:
Human    65 ILHQTPDSQVYL--------SIACGANREEITKH--WDWLEQNIMKTLSVFDSNEDITNFVQGKI 119

  Fly   575 HGRITPEMK---ADEEGLTKERWQLLNVNGVL-----ENATEFYRLVYFGGVQPELRQEVWPYL- 630
            .|.|..|.|   |.|:...|.|..||......     |....:|...|:.|..|   .:.|.||
Human   120 RGLIAEEGKHCFAKEDDPEKFREALLKFEKCFGLPEKEKLVTYYSCSYWKGRVP---CQGWLYLS 181

  Fly   631 ---LGHYAF--GSTTEDRKKQDETCK---------------------HYYET--------TMSEW 661
               |..|:|  ||..:.....||..|                     ||:..        .:.|.
Human   182 TNFLSFYSFLLGSEIKLIISWDEVSKLEKTSNVILTESIHVCSQGENHYFSMFLHINQTYLLMEQ 246

  Fly   662 LAVDAIVQQREKEK-------------TARAVAKLSSGSNSGNDRTVRAADLEAGGDLENEVFE- 712
            ||..||.:..:||.             |.|.:      .|..:.....|......|:...||.|
Human   247 LANYAIRRLFDKETFDNDPVLYNPLQITKRGL------ENRAHSEQFNAFFRLPKGESLKEVHEC 305

  Fly   713 ----DISDISDPGDLEFDEQQ--QQQQQQAECAVSGNHLTVKPIPRAM---KTSTDSGHVDESFN 768
                ..|..:..|.:...|..  ...|...:|:|      :.|:...:   ||:..|..|..|..
Human   306 FLWVPFSHFNTHGKMCISENYICFASQDGNQCSV------IIPLREVLAIDKTNDSSKSVIISIK 364

  Fly   769 ELDEPDEEDNKQKQQQDEKISESESKLPDYRKLEEQI--------NQEPSCSASTASSYETVGPG 825
                             .|.:....::.|:.:|..::        .|....|...|.|.|:..|.
Human   365 -----------------GKTAFRFHEVKDFEQLVAKLRLRCGAASTQYHDISTELAISSESTEPS 412

  Fly   826 EVHQRPNSDTRSVLSPEYLSADDLQLPDDEDAVRPPPPPAAAAVIITKASVDITNWERSPKAAEG 890
            :     |.:.:|:.|....|                      ..:.|:|.:.:.:    |:..|.
Human   413 D-----NFEVQSLTSQRECS----------------------KTVNTEALMTVFH----PQNLET 446

  Fly   891 DQMSPLEEQAGESG--------GAGVNMDALQQPK-------------------SACASPASSNG 928
            .....|:|:..|..        |.||:|...::.:                   |...:..::|.
Human   447 LNSKMLKEKMKEQSWKILFAECGRGVSMFRTKKTRDLVVRGIPETLRGELWMLFSGAVNDMATNP 511

  Fly   929 GVYSSELLEQ----FGLNLHRIEKDVQRCDRNYWYFANE-NLDKLRNVISTYVWEHLDVGYMQGM 988
            ..| :|::||    ..|....||:|::|....:..|.:: .:..||.|::.|.:.:..:||.|.|
Human   512 DYY-TEVVEQSLGTCNLATEEIERDLRRSLPEHPAFQSDTGISALRRVLTAYAYRNPKIGYCQAM 575

  Fly   989 CDLVAPLLVIFDDESLSYSCFCKLMERMIENFPSGGAMDMHFANMRSLIQILDSEMYD------- 1046
             :::..:|:::..|..::.....:.|||:.:          :.|.|.:..::|..:::
Human   576 -NILTSVLLLYAKEEEAFWLLVAVCERMLPD----------YFNRRIIGALVDQAVFEELIRDHL 629

  Fly  1047 --LMDSNGDYTHF-YFCYRWFLLDFKREL------------VYDDVFATWEVIWAAKHIASGHFV 1096
              |.:...|.|.| .....|||..|...|            .||.:.|                :
Human   630 PQLTEHMTDMTFFSSVSLSWFLTLFISVLPIESAVNVVDCFFYDGIKA----------------I 678

  Fly  1097 LFLALALLETYRDIILSNSMD---FTDVIKFFNEMAER 1131
            |.|.||:|:...|.:|:...|   .|.:.:||:.:..:
Human   679 LQLGLAILDYNLDKLLTCKDDAEAVTALNRFFDNVTNK 716

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tbc	NP_608395.6	RUN_SGSM1_like	21..214	CDD:439049
		PH_RUTBC	292..466	CDD:275431
		TBC	923..1087	CDD:214540	39/190 (21%)
TBC1D8B	NP_060222.2	PH-GRAM1_TBC1D8B	156..254	CDD:275419	23/100 (23%)
		PH-GRAM2_TBC1D8B	296..388	CDD:270159	19/114 (17%)
		TBC	486..694	CDD:214540	46/235 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1035..1066