DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tbc and Tbc1d8

DIOPT Version :9

Sequence 1:	NP_001285494.1	Gene:	tbc / 318059	FlyBaseID:	FBgn0052506	Length:	1155	Species:	Drosophila melanogaster
Sequence 2:	XP_017177250.1	Gene:	Tbc1d8 / 54610	MGIID:	1927225	Length:	1160	Species:	Mus musculus

Alignment Length:	726	Identity:	133/726 - (18%)
Similarity:	247/726 - (34%)	Gaps:	220/726 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   564 STVRTHLSGLVHGRITPEMKADEEGLTKERWQLLNVNG-----VLENATEFYRLVYFGGVQPELR 623
            |.|:..:..|:....:..:...||...|.|..|:....     ..|....:|....:.|..|
Mouse   127 SFVKGKVKALIAEETSSRLAEQEEEPEKFREALVKFEARFNFPEAEKLVTYYSCCCWKGRVP--- 188

  Fly   624 QEVWPYL-LGH---YAFGSTTE--------DRKKQDETCKHYYETTM-----------SEWLAVD 665
            ::.|.|| :.|   |:|....|        |.:|.:.|...:...|:           |.:|.:|
Mouse   189 RQGWLYLSINHLCFYSFFLGKELKLVIPWVDIQKLERTSNVFLTDTIRITTQNKERDFSTFLNLD 253

  Fly   666 AIVQQREKEKTARAVAKLSSGSNSGNDRTVRAADLEAGGDLENEVFEDISDISDPG-----DLEF 725
            .:.:..|                       :.||:.....|:||||:...|:.:|.     |||.
Mouse   254 EVFKIME-----------------------QLADVTLRRLLDNEVFDLDPDLQEPSQITKRDLEA 295

  Fly   726 DEQ------------QQQQQQQAECAVSGNHLTVKPIPRAMKTSTDSGHVDESFNELDEPDEEDN 778
            ..|            :::....|:|::      ..|..|.    ..:|.:..|.:.:.....||.
Mouse   296 RAQNEFFRAFFRLPREEKLHAVADCSL------WTPFSRC----HTAGRIFSSDSYICFASREDG 350

  Fly   779 -------KQKQQQDEKISESESKLPD-------------YRKLEEQIN-------QEPSCSASTA 816
                   .::....||: |..|.||:             :.:|:::.|       :.....|:..
Mouse   351 CCNVVLPLREVVSIEKM-EDTSLLPNPIIVSIRSKMAFQFIELKDRENLVEGLLLRLKQVHANHP 414

  Fly   817 SSYETVGPGEVHQRPNSDTRSVLSPEYLSAD-------DLQL-----PDDEDAVRPPPPPAAAAV 869
            ..|||        .|:.|  .:.||.:.||.       ||::     .::.:..||.|.|.....
Mouse   415 VHYET--------SPSDD--DMASPVFYSASICTDKFGDLEMVASQSSEEREEKRPLPHPEPLTA 469

  Fly   870 I------------ITKASVDITNWE-------------RSPKAAEGDQMSPLEEQAGESGGAGVN 909
            :            :::..:.|:.|.             |:.|..:...|...|...|.
Mouse   470 VFQQSGSQSPDSRLSREQIKISLWNDHFVEYGRTVCMFRTEKIRKLVAMGIPESLRGR------- 527

  Fly   910 MDALQQPKSACASPASSNGGVYSSELLEQFG---LNLHRIEKDVQRCDRNYWYFANE-NLDKLRN 970
               |....|...:..:|:.|.|.:.:.:..|   |....||:|:.|....:..|.|| .:..||.
Mouse   528 ---LWLLFSDAVTDLASHPGYYGNLVEQSLGRCCLVTEEIERDLHRSLPEHPAFQNETGIAALRR 589

  Fly   971 VISTYVWEHLDVGYMQGMCDLVAPLLVIFDDESLSYSCFCKLMERMIENFPS----GGAMDMHFA 1031
            |::.|...:..:||.|.| :::..:|:::..|..::.....:.|||:.::.:    |..:|....
Mouse   590 VLTAYAHRNPKIGYCQSM-NILTSVLLLYAKEEEAFWLLVAVCERMLPDYFNHRVIGAQVDQSVF 653

  Fly  1032 NMRSLIQILDSEMYDLMDSNGDYTHF-YFCYRWFLLDFKRELVYDDVFATWEVIWAAKHIASGHF 1095
            .     :::..::.:|.:...|.:.. .....|||          .:|.:...:.:|.|:....|
Mouse   654 E-----ELIKEQLPELAEHMSDLSALASISLSWFL----------TLFLSIMPLESAVHVVDCFF 703

  Fly  1096 ------VLFLALALLETYRDIILSNSMD---------FTDVIK--------------FFNEMAER 1131
                  :..|.||:||...:.:.|:..|         |.|.||              ||::..|.
Mouse   704 YDGIKAIFQLGLAVLEANAEELCSSKDDGQALMVLSRFLDHIKNEDSPGPPIGSHHAFFSDDQEP 768

  Fly  1132 HNAQSVLQLAR 1142
            :....:..|.|
Mouse   769 YPVTDIADLIR 779

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tbc	NP_001285494.1	RUN	45..218	CDD:280855
		PH_RUTBC	292..466	CDD:275431
		TBC	923..1087	CDD:214540	33/172 (19%)
Tbc1d8	XP_017177250.1	PH-GRAM1_TBC1D8	171..269	CDD:270156	21/123 (17%)
		PH-GRAM2_TBC1D8	311..406	CDD:270160	16/105 (15%)
		TBC	519..725	CDD:214540	45/231 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900