Protein Alignment tbc and Sgsm1

DIOPT Version :9

• Sequence 1: NP_001285494.1
• Gene: tbc / 318059
• FlyBaseID: FBgn0052506
• Length: 1155
• Species: Drosophila melanogaster
• Sequence 2: XP_006535185.1
• Gene: Sgsm1 / 52850
• MGIID: 107320
• Length: 1148
• Species: Mus musculus
• Alignment Length: 1255
• Identity: 550/1255 - (43%)
• Similarity: 738/1255 - (58%)
• Gaps: 222/1255 - (17%)

  Fly     9 SDYKERLIASVKKEVKQLMEEAVTKKYVHEESSSVTSLCGAVEACLSQGLRRRALGLFKTSSTTA 73
            ::.::||:.:|||||||:||||||:|:|||:||.:.|.|.|||||:..||||||.|..:::...|
Mouse     8 AETRQRLLRTVKKEVKQIMEEAVTRKFVHEDSSHIISFCAAVEACVLHGLRRRAAGFLRSNKIAA 72

  Fly    74 LLHKIAKSCPEAEHISKLVQEIEASDPSKRS--SSSSDSFQRPPMLKKSSSNSMSTGTNAAASTS 136
            |..|:.|..|.||.:|:.|||:|....|.|:  ....::.::.|.|
Mouse    73 LFMKVGKGFPPAEELSRKVQELEQLIESARNQIQGLQENVRKLPKL------------------- 118

  Fly   137 SASASISVSASTSSMSLASMKYLWIRLALYEKRLTKIIEYLVSNASSFYDRDSLVADSDYGSILS 201
                        .::|..::|:||||.||:|:.|.||:.|||.|:|.:|::::|:.|...|.||:
Mouse   119 ------------PNLSPLAIKHLWIRTALFERVLDKIVHYLVENSSKYYEKEALLMDPVDGPILA 171

  Fly   202 SLLVGPCALEFTRAKTADHYWTDPHADELVQRHRI-SSCRRSSSTCSRPAIINFKRSLNTSSDEA 265
            ||||||||||:|:.|||||:||||.|||||||||| ||..|..|...|||:...||..:.|.|:.
Mouse   172 SLLVGPCALEYTKMKTADHFWTDPSADELVQRHRIHSSHLRQDSPTKRPALCIQKRHSSGSMDDR 236

  Fly   266 GTGSFKSIASASVAKDYVESLHQNAKATLLYGKNNVQVLPKDVAEPMPGYLSLHQHIQTLTIKWT 330
            .:.|         |:|||||||||::||||||||||.|.|:|..|.:||||||||....:|:|||
Mouse   237 PSIS---------ARDYVESLHQNSRATLLYGKNNVLVQPRDDMEAVPGYLSLHQTADVMTLKWT 292

  Fly   331 PNQLMNGYTEAEEAEDID--KDAFWAYALNINVDEIVYVHCHQSRGEDSGGTVILVGQDGVQRPP 393
            |||||||     ...|:|  |..:|.||:.|.::||||:||||.  .||||||:||.|||:||||
Mouse   293 PNQLMNG-----SVGDLDYEKSVYWDYAVTIRLEEIVYLHCHQQ--VDSGGTVVLVSQDGIQRPP 350

  Fly   394 IHFPEGGHMQQFLSCLETGLLPHGQLDPPLWSQRGIGKMFLWPRSMRRRILPSVMESV-----DE 453
            ..||:|||:.|||||||.|||||||||||||||||.||:|  |: :|:|......||.     |:
Mouse   351 FRFPKGGHLLQFLSCLENGLLPHGQLDPPLWSQRGKGKVF--PK-LRKRSPQGSSESTSSDKEDD 412

  Fly   454 TPIDYVFRIVSKSRHEEFAA--------------------------------------------T 474
            ...||||||:......||.|                                            |
Mouse   413 EATDYVFRIIYPGTQSEFVALDLMGSPRPVSIGPAWMMLAAGQSMLVVAKGLQWAQTRGCLTIPT 477

  Fly   475 HSILD------------------FVRSTPRRAQLSSCSTTGSSD------CSNKSLSIDQFPMES 515
            .|:.:                  ..:.:||::..||||.:||:|      |:::         .:
Mouse   478 RSVKEQPPMPQDLMDVSMNNLPPLWQPSPRKSSCSSCSQSGSADGGSTNGCNHE---------RA 533

  Fly   516 PLILQQQQQQQQQLLQAQSTSIEMVCSTMRRQIISRAFYGWLAYCRHLSTVRTHLSGLV-HGRIT 579
            ||                    :::|..|:.||:||||||||||||||||||||||.|| |..::
Mouse   534 PL--------------------KLLCDNMKYQILSRAFYGWLAYCRHLSTVRTHLSALVNHMIVS 578

  Fly   580 PEMKADE-EGLTKERWQLLNVNGVLENATEFYRLVYFGGVQPELRQEVWPYLLGHYAFGSTTEDR 643
            |::..|. :|||...|:....:.......|..||:|:||||||:|:.|||:|||||.||.|..:|
Mouse   579 PDLPCDAGQGLTASIWEKYIQDSTTYPEQELLRLIYYGGVQPEIRRAVWPFLLGHYQFGMTEMER 643

  Fly   644 KKQDETCKHYYETTMSEWLAVDAIVQQREKEKTARAVAKLSSGSNSGN--------DRTV----- 695
            |:.||.....|..||||||..:|||:|||:|..|.|:||.|||::..:        |.|:
Mouse   644 KEVDEQIHACYAQTMSEWLGCEAIVRQRERESHAAALAKCSSGASLDSHLHRMLHRDSTISNESS 708

  Fly   696 -------RAADLEAGGDLENEVFEDISDISDPGDLEFDEQQQQQQQQAECAVSGNHLTVKPIPRA 753
                   :...|::......:|||.:.::      |..|.:.:.:::.....:||       |..
Mouse   709 QSCSSGRQNLRLQSDSSSSTQVFESVDEV------EQTEAEGRSEEKHPKIPNGN-------PAN 760

  Fly   754 MKTSTDSGHVDESFNELDEPDEEDNKQKQQQDEKISESESKLPD-YRKLEEQINQEPSCSASTAS 817
            ...|.||||  .|.:.......|.::.....::.:.:::..||. :|..:..:....|..|:|:
Mouse   761 GTCSPDSGH--PSSHNFSSGLSEHSEPSLSTEDSVLDAQRSLPAVFRPGDSSVEDGQSSEATTS- 822

  Fly   818 SYETVGPGE---VHQRPNSDTRSVLS-PEYLSAD---DLQLPDDEDAVRPPPPPAAAAVIITKAS 875
              ....|.|   |.....||..:..| .|::|..   |:.||:.:.||....|..|
Mouse   823 --RDEAPREELAVQDSLESDLLANESLEEFMSIPGSLDVALPEKDGAVMDGWPGEA--------- 876

  Fly   876 VDITNWERSPKAAEGDQMSPLEEQAGESGGAGVNMDALQQPKSACASPASSNGGVYSSELLEQFG 940
                  ::..:|...|.:|  ||...||....:...|:....:..|||.||:|..||.|||:.:.
Mouse   877 ------DKPSRADSEDNLS--EEPEMESLFPALASLAVTSSANNEASPVSSSGVTYSPELLDLYT 933

  Fly   941 LNLHRIEKDVQRCDRNYWYFANENLDKLRNVISTYVWEHLDVGYMQGMCDLVAPLLVIFDDESLS 1005
            :||||||||||||||:||||...||:||||::.:|:|:|:::||:||||||:||||||.|||:|:
Mouse   934 VNLHRIEKDVQRCDRSYWYFTAANLEKLRNIMCSYIWQHIEIGYVQGMCDLLAPLLVILDDEALA 998

  Fly  1006 YSCFCKLMERMIENFPSGGAMDMHFANMRSLIQILDSEMYDLMDSNGDYTHFYFCYRWFLLDFKR 1070
            :|||.:||:||.:|||.|||||.|||||||||||||||:::||..||||||||||||||||||||
Mouse   999 FSCFTELMKRMNQNFPHGGAMDTHFANMRSLIQILDSELFELMHQNGDYTHFYFCYRWFLLDFKR 1063

  Fly  1071 ELVYDDVFATWEVIWAAKHIASGHFVLFLALALLETYRDIILSNSMDFTDVIKFFNEMAERHNAQ 1135
            ||||||||:.||.||||||::|.|:|||:||||:|.||||||.|:|||||:|||||||||||||:
Mouse  1064 ELVYDDVFSVWETIWAAKHVSSAHYVLFIALALVEVYRDIILENNMDFTDIIKFFNEMAERHNAK 1128

  Fly  1136 SVLQLARSLVLQLQMIIENK 1155
            .:|||||.||.::|::||||
Mouse  1129 QILQLARDLVHKVQILIENK 1148

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tbc	NP_001285494.1	RUN	45..218	CDD:280855	65/174 (37%)
		PH_RUTBC	292..466	CDD:275431	107/180 (59%)
		TBC	923..1087	CDD:214540	118/163 (72%)
Sgsm1	XP_006535185.1	RUN	44..186	CDD:367169	64/172 (37%)
		PH_RUTBC	254..425	CDD:275431	107/180 (59%)
		TBC	<936..1105	CDD:214540	126/168 (75%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	297	1.000	Domainoid score	I1458
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H64485
Inparanoid	1	1.050	972	1.000	Inparanoid score	I320
Isobase	1	0.950	-	0	Normalized mean entropy	S3548
OMA	1	1.010	-	-		QHG48923
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002045
OrthoInspector	1	1.000	-	-		mtm8717
orthoMCL	1	0.900	-	-		OOG6_103962
Panther	1	1.100	-	-	O	PTHR22957
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3416
SonicParanoid	1	1.000	-	-		X1347
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.810