DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tbc and Tbc1d5

DIOPT Version :9

Sequence 1:	NP_001285494.1	Gene:	tbc / 318059	FlyBaseID:	FBgn0052506	Length:	1155	Species:	Drosophila melanogaster
Sequence 2:	XP_008764990.1	Gene:	Tbc1d5 / 501088	RGDID:	1561626	Length:	827	Species:	Rattus norvegicus

Alignment Length:	249	Identity:	57/249 - (22%)
Similarity:	101/249 - (40%)	Gaps:	59/249 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   922 SPASSNGGVYSSELLEQFGLNLHRIEKDVQRCDRNYWYFANENLDK-LRNVISTYVWEHLDVGYM 985
            :|.|.:.|...::..:...|. ..||:||:|......:|..||:.| |.:|:..|..|:..:.|.
  Rat   140 NPLSQDEGSLWNKFFQDKELR-SMIEQDVRRTFPEMQFFQQENVRKILTDVLFCYARENEQLLYK 203

  Fly   986 QGMCDLVAPLL------------------------VIFDDESL---SYSCFCKLMER---MIENF 1020
            |||.:|:||::                        .:.:.|.|   :|:.|.:|||.   ....|
  Rat   204 QGMHELLAPIIFTLHCDHQAFLHASESAQPSEEMKTLLNPEYLEHDAYAMFSQLMETAEPWFSTF 268

  Fly  1021 PSGGAM-------DMHFANMRSL---IQILD--SEMYDLMDSNGD---YTHF--------YFCYR 1062
            ...|..       .:.||..:.|   :.|:.  :::.|.:....|   |.|.        .:..|
  Rat   269 EHDGQKGKETLMPPIPFARPQDLGPTVAIVTKVNQIQDHLLKKHDTELYMHLNRLEIPPQIYGLR 333

  Fly  1063 WFLLDFKRELVYDDVFATWEVIWA-AKHIASGHFVLFLALALLETYRDIILSNS 1115
            |..|.|.||....|:...|:.::| ..|::   .|.::..|:|...||.::|::
  Rat   334 WVRLLFGREFPLQDLLVVWDALFADGLHLS---LVDYVFTAMLLYIRDALISSN 384

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tbc	NP_001285494.1	RUN	45..218	CDD:280855
		PH_RUTBC	292..466	CDD:275431
		TBC	923..1087	CDD:214540	50/218 (23%)
Tbc1d5	XP_008764990.1	TBC	79..381	CDD:214540	56/244 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900