DRSC/TRiP Functional Genomics Resources

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Protein Alignment tbc and TBC1D25

DIOPT Version :10

Sequence 1:NP_608395.6 Gene:tbc / 318059 FlyBaseID:FBgn0052506 Length:1155 Species:Drosophila melanogaster
Sequence 2:NP_001335191.1 Gene:TBC1D25 / 4943 HGNCID:8092 Length:704 Species:Homo sapiens


Alignment Length:555 Identity:102/555 - (18%)
Similarity:170/555 - (30%) Gaps:253/555 - (45%)


- Green bases have known domain annotations that are detailed below.


  Fly   830 RPNSDTR-----SVLSPEYLSADDLQLPDDEDAVRPPPPPAAAAVIITKASVDITNWERSPKAAE 889
            ||:.|:.     .::||:.:...|:.|.:...::.....|...: |:|:....::..::....:.
Human   141 RPSEDSPLLEDWDIISPKDVIGSDVLLAEKRSSLTTAALPFTQS-ILTQVGRTLSKVQQVLSWSY 204

  Fly   890 GDQMSPLEEQAGES------------------------GGA-------------GVNMDAL---- 913
            |:.:.|.:....::                        ||.             .|..|.|    
Human   205 GEDVKPFKPPLSDAEFHTYLNHEGQLSRPEELRLRIYHGGVEPSLRKVVWRYLLNVYPDGLTGRE 269

  Fly   914 ------------QQPKSACASPASSNGGVYSSELLEQFGLNLHRIEKDVQRCDRNYWYFA----N 962
                        :|.||..|..|:.          |........:.|||.|.||.:.|:|    .
Human   270 RMDYMKRKSREYEQLKSEWAQRANP----------EDLEFIRSTVLKDVLRTDRAHPYYAGPEDG 324

  Fly   963 ENLDKLRNVISTYVWEHLDVGYMQGMCDLVAPLLVIFDDESLSYSCFCKLMERMIENF-PSGGAM 1026
            .:|..|.::::||...|..|.|.|||.||.:|:|.:.|.|..::.|||.:|:|:..|| |.|.||
Human   325 PHLRALHDLLTTYAVTHPQVSYCQGMSDLASPILAVMDHEGHAFVCFCGIMKRLAANFHPDGRAM 389

  Fly  1027 DMHFANMRSLIQILDSEMYD-LMDSNGDYTHFYFCYRWFLLDFKRELVYDDVFATWEVIW----- 1085
            ...||:::.|::..|.:.|. |.::..|  ..:|||||.||:.|||..:||.....||.|     
Human   390 ATKFAHLKLLLRHADPDFYQYLQEAGAD--DLFFCYRWLLLELKREFAFDDALRMLEVTWSSLPP 452

  Fly  1086 -----------------------------------------------AAKHIASGH--------- 1094
                                                           |..|:|:..         
Human   453 DPPEHEVELVGPPSQVADAGFGGHRGWPVRQRHMLRPAGGGGSTFEDAVDHLATASQGPGGGGRL 517

  Fly  1095 ----------------------------------------------------------------- 1094
                                                                             
Human   518 LRQASLDGLQQLRDNMGSRRDPLVQLPHPAALISSKSLSEPLLNSPDPLLSSFSHPDSPSSSSPP 582

  Fly  1095 --------------------------------------------------FVLFLALALLETYRD 1109
                                                              |:|||.||:|..:||
Human   583 STQEASPTGDMAVGSPLMQEVGSPKDPGKSLPPVPPMGLPPPQEFGRGNPFMLFLCLAILLEHRD 647

  Fly  1110 IILSNSMDFTDVIKFFNEMAERHNAQSVLQLARSL 1144
            .|:.|.:|:.::...|:.:..:|:...||:.||:|
Human   648 HIMRNGLDYNELAMHFDRLVRKHHLGRVLRRARAL 682

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
tbcNP_608395.6 RUN_SGSM1_like 21..214 CDD:439049
PH_RUTBC 292..466 CDD:275431
TBC 923..1087 CDD:214540 59/221 (27%)
TBC1D25NP_001335191.1 TBC 241..470 CDD:214540 68/240 (28%)
Blue background indicates that the domain is not in the aligned region.

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