Protein Alignment tbc and tbc1d15

DIOPT Version :9

• Sequence 1: NP_001285494.1
• Gene: tbc / 318059
• FlyBaseID: FBgn0052506
• Length: 1155
• Species: Drosophila melanogaster
• Sequence 2: XP_005159143.1
• Gene: tbc1d15 / 492676
• ZFINID: ZDB-GENE-041111-251
• Length: 665
• Species: Danio rerio
• Alignment Length: 851
• Identity: 153/851 - (17%)
• Similarity: 266/851 - (31%)
• Gaps: 402/851 - (47%)

  Fly   336 NGYTEAEEAEDIDKDAFWAYALNINVDEI--VYVHCHQSRGEDSGGTVILVG-QDGVQRPPIHFP 397
            ||...:....:.:|.||     :.||.::  |.|.|       .|.:.:... :||...|.|||.
Zfish   109 NGDGGSNHVNEQNKRAF-----SFNVCDLRSVTVKC-------EGWSYLTFRLKDGTALPAIHFH 161

  Fly   398 EGGHMQQFLSCLETGLLPHGQLDPPLWSQRGIGKMFLWPRSMRRRILPSVMESVDETPIDYVFRI 462
            :||                             .|.||  .|:|:.:      .::|:|.|....|
Zfish   162 QGG-----------------------------SKAFL--DSLRKSV------QINESPDDESVLI 189

  Fly   463 V---SKSRHEEFAATHSILD-----FVRSTPRRAQLSSCSTT--GSSDCSN--------KSLSID 509
            |   ||:..:.|   .::||     ||:   ::.:....:||  |.|..:|        ..|...
Zfish   190 VSTYSKAFSQSF---ENLLDDTNYGFVQ---QKFKKDPYTTTLGGFSKVTNYLFDAFRAPELECQ 248

  Fly   510 QFPME------SPLI--LQQQQQQQQQLLQAQSTSIEMVCSTMRRQIISRAFYGWLAYCRHLSTV 566
            |.|.|      ..||  |:..||::...                 ::|:|...|
Zfish   249 QRPAEEVADVLGELIPGLEINQQEEPGF-----------------EVITRLDLG----------- 285

  Fly   567 RTHLSGLVHGRITPEMKADEEG-LTKERW-QLLNVNGVLENATEFYRLVYFGGVQPELRQEVWPY 629
                         |..:....| :|.|.| :..::.|.:.|.......::.||:...:|:|.|.:
Zfish   286 -------------PRPEMQRTGPVTMEEWAKYQDLEGRMTNLPHLKDAIFKGGLCHAVRKEAWKF 337

  Fly   630 LLGHYAFGSTTEDRKKQDETCKHYYETTMSEWLAVDAIVQQREKEKTARAVAKLSSGSNSGNDRT 694
            |||::.:.||.|:||                      ::|:|:.::..|...:..|.|
Zfish   338 LLGYFPWSSTHEERK----------------------LLQKRKTDEYFRMKLQWKSVS------- 373

  Fly   695 VRAADLEAGGDLENEVFEDISDISDPGDLEFDEQQQQQQQQAECAVSGNHLTVKPIPRAMKTSTD 759
                                            |:|:::
Zfish   374 --------------------------------EEQERR--------------------------- 379

  Fly   760 SGHVDESFNELDEPDEEDNKQKQQQDEKISESESKLPDYRKLEEQINQEPSCSASTASSYETVGP 824
                                            .|:|.|||.|
Zfish   380 --------------------------------NSRLRDYRSL----------------------- 389

  Fly   825 GEVHQRPNSDTRSVLSPEYLSADDLQLPDDEDAVRPPPPPAAAAVIITKASVDITNWERSPKAAE 889
                                                                             
Zfish   390 ----------------------------------------------------------------- 389

  Fly   890 GDQMSPLEEQAGESGGAGVNMDALQQPKSACASPASSNGGVYSSELLEQFGLNLHRIEKDVQRCD 954
                                                                    |||||.|.|
Zfish   390 --------------------------------------------------------IEKDVNRTD 398

  Fly   955 RNYWYFANENLDK-----LRNVISTYVWEHLDVGYMQGMCDLVAPLLVIFDDESLSYSCFCKLME 1014
            ||..::  |.||.     |.:::.||.....|:||:|||.||::|:|.:.::|..::.||...|:
Zfish   399 RNNKFY--EGLDNPGLILLHDILMTYCMYDFDLGYVQGMSDLLSPILFVMENEVDAFWCFVSFMD 461

  Fly  1015 RMIENFPSG-GAMDMHFANMRSLIQILDSEMYDLMDSNGDYTHFYFCYRWFLLDFKRELVYDDVF 1078
            .|.|||... ..|......:.:|:::||...::.:::. |..:.|||:||.|:.|||||.:.||.
Zfish   462 EMHENFEEQMQGMKTQLIQLSTLLRLLDLAFWNYLEAQ-DSGYLYFCFRWLLIRFKRELHFQDVL 525

  Fly  1079 ATWEVIWAAKHIASGHFVLFLALALLETYRDIILSNSMDFTDVIKFFNEMAERHNAQSVLQLARS 1143
            ..|||:|.  .:...:|.|.:..|:|::.:..|:.....|.:::|..||::.:.:.:.:|..:.|
Zfish   526 RLWEVMWT--RLPCQNFHLLVCCAILDSEKQKIMDRKYGFNEILKHINELSMKLDIEEILSKSES 588

  Fly  1144 LVLQLQ 1149
            :.:|::
Zfish   589 ICMQIK 594

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tbc	NP_001285494.1	RUN	45..218	CDD:280855
		PH_RUTBC	292..466	CDD:275431	30/135 (22%)
		TBC	923..1087	CDD:214540	55/169 (33%)
tbc1d15	XP_005159143.1	DUF3548	4..220	CDD:192931	36/165 (22%)
		TBC	322..557	CDD:214540	85/503 (17%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810