Protein Alignment tbc and tbc1d16

DIOPT Version :10

• Sequence 1: NP_608395.6
• Gene: tbc / 318059
• FlyBaseID: FBgn0052506
• Length: 1155
• Species: Drosophila melanogaster
• Sequence 2: XP_068072870.1
• Gene: tbc1d16 / 450056
• ZFINID: ZDB-GENE-041010-179
• Length: 728
• Species: Danio rerio
• Alignment Length: 1001
• Identity: 189/1001 - (18%)
• Similarity: 287/1001 - (28%)
• Gaps: 462/1001 - (46%)

  Fly   252 INFKRSLNTSSDEA--------GTGSFKSIASASVAKDYVESLHQNAKATLLYGKNNVQVLPKDV 308
            ::|.|.|..:|.:|        |||..:|:....:                ::.||||.|.|
Zfish    12 MSFGRLLRRASSKASDFLTFNVGTGGSRSVLDGEI----------------IFSKNNVCVHP--- 57

  Fly   309 AEPM-------PGYLSLHQHI-----QTLTIKWTPNQLMN------------------------- 336
            |||:       ||||.:|...     .||.:.|.||..:.
Zfish    58 AEPLPGLPEHHPGYLCVHLEKDETLGSTLILTWVPNSRIQRQDEEALRYITPESSPVRRNPRRRA 122

  Fly   337 --------GYTEAEEAEDIDKDAFWAYALNINVDEIVYVHCHQSRGEDSGGTVILVGQDGVQRP- 392
                    ...|.|||.|.:.......||....||   ..|..|..|.|..:.|....|....|
Zfish   123 HRSHSRPPAAPEEEEAADEEGQEPQNQALLEEGDE---GSCELSADEVSRDSTIGSDSDTFSSPF 184

  Fly   393 ---PIHFPEG-GHMQQFL-----SCLETGLLPH-----GQLDPPLWSQRGIGKMFLWPRSMRRRI 443
               |:....| .....||     .|.|.  :.|     ..||....|:....:...|........
Zfish   185 CLSPVSEALGESSSSVFLDNESRECDEP--MAHSASSASSLDSHAPSESSHSQGVRWEEQQNVMA 247

  Fly   444 LPSVMESVDETPIDYVFRI----------------------VSKSRHEEFAAT---HSILDFVRS 483
            |..:..         |||:                      |..||..::...   |:.||.:..
Zfish   248 LEHLCG---------VFRVDLGHMRSLRLFFSDEACTCGQLVIASRESQYKILHFHHAGLDKLAE 303

  Fly   484 TPRRAQLSSCSTTGSSDCSNKSLSIDQFPMESPLILQQQQQQQQQLLQAQSTSIEMVCSTMRRQI 548
            ..:  |...|..|...|..:...|..||.:..|.:...:...:::|              .||..
Zfish   304 VFQ--QWKCCRETQLKDQVSDEKSCMQFSIRRPTLPSAEMHPEERL--------------YRRLD 352

  Fly   549 ISRAFYGWLAYCRHLSTVRTHLSGLVHGRITPEMKADEEGLTKERWQLLNVNGVLENATEFYRL- 612
            :|    .||   |||:                                 |...|||.    |:|
Zfish   353 VS----SWL---RHLN---------------------------------NSGQVLEE----YKLR 373

  Fly   613 --VYFGGVQPELRQEVWPYLLGHYAFGSTTEDRKKQDETCKHYYETTMSEWLAVDAIVQQREKEK 675
              ::|||:.|.:|.||||:||.:|::.||:|:|:               .|.     :|:|
Zfish   374 KAIFFGGIDPSIRGEVWPFLLHYYSYDSTSEERE---------------AWR-----LQKR---- 414

  Fly   676 TARAVAKLSSGSNSGNDRTVRAADLEAGGDLENEVFEDISDISDPGDLEFDEQQQQQQQQAECAV 740
                                                              .|.|..||::
Zfish   415 --------------------------------------------------GEYQDIQQRR----- 424

  Fly   741 SGNHLTVKPIPRAMKTSTDSGHVDESFNELDEPDEEDNKQKQQQDEKISESESKLPDYRKLEEQI 805
                |::.|                                        |..|:.  :||:
Zfish   425 ----LSMSP----------------------------------------EEHSEF--WRKV---- 439

  Fly   806 NQEPSCSASTASSYETVGPGEVHQRPNSDTRSVLSPEYLSADDLQLPDDEDAVRPPPPPAAAAVI 870
                                                                             
Zfish   440 ----------------------------------------------------------------- 439

  Fly   871 ITKASVDITNWERSPKAAEGDQMSPLEEQAGESGGAGVNMDALQQPKSACASPASSNGGVYSSEL 935
                                                                             
Zfish   440 ----------------------------------------------------------------- 439

  Fly   936 LEQFGLNLHRIEKDVQRCDRNYWYFA---NENLDKLRNVISTYVWEHLDVGYMQGMCDLVAPLLV 997
              ||     .::|||.|.||:..:|.   |.|::.:|.::..|...:.|:||.|||.|||||||.
Zfish   440 --QF-----TVDKDVVRTDRSNMFFRGENNPNVEIMRRILLNYAVFNPDMGYCQGMSDLVAPLLT 497

  Fly   998 IFDDESLSYSCFCKLMERMI-ENFPSGGAMDMHFANMRSLIQILDSEMYDLMDSNG-DYTHFYFC 1060
            ...|||.::.||..|||..| .:.|....|:.....:|.|::::....:..:...| |.....||
Zfish   498 EIQDESDTFWCFVGLMENTIFISSPRDEDMERQLMYLRELLRLMLPRFHQHLTRLGEDGLQLLFC 562

  Fly  1061 YRWFLLDFKRELVYDDVFATWEVIWAAKHIASGHFVLFLALALLETYRDIILSNSMDFTDVIKFF 1125
            :||.||.||||....:....||..||  |..:.:|.|||.:|::..|.|.:....:....::..|
Zfish   563 HRWVLLCFKREFPDAEALRMWEACWA--HYQTDYFHLFLCVAIIVLYGDDVTEQQLATDQMLLHF 625

  Fly  1126 NEMAERHNAQSVLQLARSLVLQLQMI 1151
            :.::...|.:.||:.||||:.|.:::
Zfish   626 SNLSMHMNGELVLRKARSLLYQFRLL 651

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tbc	NP_608395.6	RUN_SGSM1_like	21..214	CDD:439049
		PH_RUTBC	292..466	CDD:275431	51/255 (20%)
		TBC	923..1087	CDD:214540	54/168 (32%)
tbc1d16	XP_068072870.1	PH_RBD	46..>93	CDD:432305	17/65 (26%)
		TBC	379..607	CDD:214540	89/495 (18%)