DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tbc and tbc1d16

DIOPT Version :9

Sequence 1:	NP_001285494.1	Gene:	tbc / 318059	FlyBaseID:	FBgn0052506	Length:	1155	Species:	Drosophila melanogaster
Sequence 2:	XP_012814267.2	Gene:	tbc1d16 / 448159	XenbaseID:	XB-GENE-986691	Length:	727	Species:	Xenopus tropicalis

Alignment Length:	999	Identity:	180/999 - (18%)
Similarity:	302/999 - (30%)	Gaps:	449/999 - (44%)

- Green bases have known domain annotations that are detailed below.

  Fly   256 RSLNTSSDEAGTGSFKSIASASVAKDYVESLHQNAKATLLYGKNNVQVLP----KDVAEPMPGYL 316
            |.|..:|.:|  ..|.:::|...:...::       ..:::.||||.|.|    :||....||||
Frog     5 RLLRRASSKA--SDFLTLSSGGGSSSILD-------GEIIFSKNNVCVHPPELLQDVGSHHPGYL 60

  Fly   317 SLHQHIQ-----TLTIKWTPNQLMNGYTE------AEEAEDIDKDAFWAYALNINVDEIVYVHCH 370
            .::....     ||.:.|.||..:....|      ..|:..|.|:.
Frog    61 CVYMEKDEFLGTTLILAWVPNSRIQRQDEEALRYITPESSPIRKNP------------------- 106

  Fly   371 QSRGEDSGGTV-------ILVGQDGVQRPPIHFPEGGHMQQFLSCLETGLLPHGQLDPPLWSQRG 428
            :.|.....|:.       .::.::.|.| .::.|.                   :.||...|..|
Frog   107 RKRNRQPPGSAPTTRSKPAIISKEDVGR-EVNSPT-------------------ERDPSYGSAEG 151

  Fly   429 IGKMFLWPRSMRRRILPSVMESVDETPIDYVFRIVSK-----SRHEEFAATHSILD--------- 479
            :.:              ...:..||..:|.....|||     |..:.|::...:..
Frog   152 VEE--------------GTEQGEDERSLDLSSDEVSKDSTLDSDSDAFSSPFCLSPISEALGESS 202

  Fly   480 ---FVRSTPRRAQLSSCSTTGSSDCSNKSLSIDQFPMESPLILQQQQQQQQQLLQAQS------- 534
               |:.:..|....|..|:..||..:|     .|.|..:...:..:.::||:||..:.
Frog   203 SSVFLENENRDESNSHMSSYASSLNAN-----SQLPEINGQGVPAKWEEQQKLLALEQTCGVFRV 262

  Fly   535 -----------------TSIEMVCSTMRRQI------------ISRAFYGWLAYCR--------- 561
                             ||.::|.::...|.            :|..|..| .|||
Frog   263 DLGQMRSLRFFFSDEACTSGQLVVASRESQYKVFHFHHGGLGKLSEVFQQW-KYCRETQLKEQQV 326

  Fly   562 -------HLSTVRTHLSGLVHGRITPEMKA-DEEGLTKE----RW-QLLNVNGVLENATEFYRLV 613
                   |.|..|.:|         |..:: .|||:.:.    .| :.||..|.:|...:..:|:
Frog   327 TEDKTCLHFSIQRPNL---------PSSESHPEEGMYRRLDVTSWLEHLNEVGQVEEEYKLRKLI 382

  Fly   614 YFGGVQPELRQEVWPYLLGHYAFGSTTEDRKKQDETCKHYYETTMSEWLAVDAIVQQREKEKTAR 678
            :|||:.|.||.||||:|||:|.:..|:|||:
Frog   383 FFGGIDPSLRGEVWPFLLGYYPWEITSEDRE---------------------------------- 413

  Fly   679 AVAKLSSGSNSGNDRTVRAADLEAGGDLENEVFEDISDISDPGDLEFDEQQQQQQQQAECAVSGN 743

Frog   414 ----------------------------------------------------------------- 413

  Fly   744 HLTVKPIPRAMKTSTDSGHVDESFNELDEPDEEDNKQKQQQDEKISESESKLPDYRKLEEQINQE 808
                     |::.     |..|.::::             |.:::|
Frog   414 ---------ALRV-----HRREEYSQI-------------QKKRVS------------------- 432

  Fly   809 PSCSASTASSYETVGPGEVHQRPNSDTRSVLSPEYLSADDLQLPDDEDAVRPPPPPAAAAVIITK 873

Frog   433 ----------------------------------------------------------------- 432

  Fly   874 ASVDITNWERSPKAAEGDQMSPLEEQAGESGGAGVNMDALQQPKSACASPASSNGGVYSSELLEQ 938
                               |||..:                                      ::
Frog   433 -------------------MSPTAQ--------------------------------------KE 440

  Fly   939 FGLNLH-RIEKDVQRCDRNYWYFA---NENLDKLRNVISTYVWEHLDVGYMQGMCDLVAPLLVIF 999
            |..|:. .::|||.|.||:..:|.   |.|::.:|.::..|......|||.|||.|||||:|...
Frog   441 FWKNVQFTVDKDVVRTDRSNQFFRGEDNPNVESMRRILLNYAVYSPGVGYSQGMSDLVAPILAEV 505

  Fly  1000 DDESLSYSCFCKLMERMI-ENFPSGGAMDMHFANMRSLIQILDSEMYDLMDSNG-DYTHFYFCYR 1062
            .|||.::.||..||:..| .:.|....|:.....:|.|::::....|..:.|.| |.....||:|
Frog   506 LDESDTFWCFVGLMQNTIFISSPRDEYMEKQLLYLRELLRLVHPRFYQHLYSLGEDGLQMLFCHR 570

  Fly  1063 WFLLDFKRELVYDDVFATWEVIWAAKHIASGHFVLFLALALLETYRDIILSNSMDFTDVIKFFNE 1127
            |.||.||||....:....||..||  |..:.:|.|||.:|::..|.|.::...:....::..|:.
Frog   571 WILLCFKREFPDSEALRMWEACWA--HYQTDYFHLFLCVAIIVLYGDDVIEQQLPTDQMLLHFSN 633

  Fly  1128 MAERHNAQSVLQLARSLVLQLQMI 1151
            :|...|.:.||:.||||:.|.:::
Frog   634 LAMHMNGELVLRKARSLLYQFRLL 657

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tbc	NP_001285494.1	RUN	45..218	CDD:280855
		PH_RUTBC	292..466	CDD:275431	36/200 (18%)
		TBC	923..1087	CDD:214540	54/169 (32%)
tbc1d16	XP_012814267.2	TBC	385..613	CDD:214540	86/496 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910