DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tbc and CG5745

DIOPT Version :9

Sequence 1:	NP_001285494.1	Gene:	tbc / 318059	FlyBaseID:	FBgn0052506	Length:	1155	Species:	Drosophila melanogaster
Sequence 2:	NP_650941.3	Gene:	CG5745 / 42498	FlyBaseID:	FBgn0038855	Length:	546	Species:	Drosophila melanogaster

Alignment Length:	511	Identity:	95/511 - (18%)
Similarity:	173/511 - (33%)	Gaps:	109/511 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   670 QREKEKTARAVAKLSSGSNSGNDRTVRAADLEAGGDLENEVFEDISDISDPGDLEFDEQQQQQQQ 734
            :||.||.|.....:..|:..|:.......:.:          :.:||..|.||.||
  Fly    67 KRELEKAAAVGVAVGRGAAPGSGMVSTFTEYQ----------KSVSDAWDMGDDEF--------- 112

  Fly   735 QAECAVSGNHLTVKPIPRAMKTSTDSGHVDESFNELDEPDEEDNKQKQQQDEKISESESKLPDYR 799
               |.:|......     |...:.|:.|.....::....:..:...:..|:...|.|.:
  Fly   113 ---CIISSTEAAA-----AAVGAGDAAHFSRQVSQTVALNVIETHSRSNQNHNASRSAN------ 163

  Fly   800 KLEEQINQEPSCSASTASSYETVGPGEVHQRPNSDTRSVLSPEYLSADDLQ-----LPDDEDAVR 859
              |...:..|..|:||....|     :....|:|:........|.....||     ..|.|...:
  Fly   164 --ESGADLVPVSSSSTDDCKE-----DRRSLPDSNENRSRLRNYPGRPQLQKISSNCQDSEYETK 221

  Fly   860 PPPPPAAAAVIITKASVDIT-----NWERSPKAAE-------GDQMSPLEEQAGESGGAGVNMDA 912
                .....|::....:|:.     :|...|:...       ...:.|..|:         .|..
  Fly   222 ----IEKFQVVLDSPQLDLVALKKISWSGVPRKMRAVSWRLLSKYLPPSSER---------RMAV 273

  Fly   913 LQQPKSACASPASSNGGVYSSELLEQFGLNLHRIEKDVQRCDRNYWYFANENLDKLRNVISTYVW 977
            |:..:........:...|.|.:..:|.  ...:|..||.|.:.....|..:.:.::...| .::|
  Fly   274 LESKRQGYQDLRHNYFRVDSQDETQQD--TYRQIHIDVPRMNPQIPLFQQQLVQEMFERI-LFIW 335

  Fly   978 --EHLDVGYMQGMCDLVAPLLVIFDDESL-------------------------SYSCFCKLMER 1015
              .|...||:||:.|||.|..::|..|:|                         |:.|..|.::.
  Fly   336 AIRHPASGYVQGINDLVTPFFIVFLQEALTPNTDLEKYDMSTLPEETRNIIEADSFWCLSKFLDC 400

  Fly  1016 MIEN--FPSGGAMDMHFANMRSLIQILDSEMYDLMDSNG-DYTHFYFCYRWFLLDFKRELVYDDV 1077
            :.:|  |...|..: ....::.|||.:|..::..:.::| ||..|.|  ||......|||.....
  Fly   401 IQDNYIFAQLGIQE-KVNQLKDLIQRIDVNLHRHLQAHGVDYLQFSF--RWMNNLLTRELPLHCT 462

  Fly  1078 FATWEVIWAAKHIASGHFVLFLALALLETYRDIILSNSMDFTDVIKFFNEMAERHN 1133
            ...|:. :.|:......|.|::..|.|..:::.::..: ||..::.....: ..||
  Fly   463 IRLWDT-YLAESDGFALFHLYVCAAFLLHWKEQLMQQN-DFQGLMLLLQNL-PTHN 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tbc	NP_001285494.1	RUN	45..218	CDD:280855
		PH_RUTBC	292..466	CDD:275431
		TBC	923..1087	CDD:214540	43/193 (22%)
CG5745	NP_650941.3	TBC	243..496	CDD:214540	54/268 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45456625
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR22957
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940